A6L6X5 (GCST_BACV8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	BVU_3828

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Aminomethyltransferase HAMAP MF_00259		PRO_1000047646

Sequences

	Sequence		Length	Mass (Da)
	A6L6X5 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: ED0E4DB418065960	FASTA	361	39,663
	10 20 30 40 50 60 MKTTPFTETH IALGAKMHEF AGYNMPIEYS GIIDEHLTVC NAVGVFDVSH MGEFWVKGPN 70 80 90 100 110 120 ALEFLQQVTS NNVATLPVGK AQYTCFPNEE GGIVDDLLVY HYESEKYLLV VNAANIEKDW 130 140 150 160 170 180 NWCVSHNTVG AELENASDRM AQLAIQGPKA MEVLQKLTPV NLSEIPYYAF TTGEFAGQKD 190 200 210 220 230 240 VIISNTGYTG AGGFELYFYP EAGQAIWKAI FEAGAPEGIK PIGLGARDTL RLEMGFCLYG 250 260 270 280 290 300 NDLSDTTSPL EAGLGWITKF VEGKNFTSRA LLEKQKAEGL KRKLIAFEMV DRGIPRHGYE 310 320 330 340 350 360 LVNADGEKIG EVTSGTMSPM RKIGIGMGYV QTAYTALGTE IFIDVRGRKL KAVVVKAPFR K

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000139 Genomic DNA. Translation: ABR41439.1.
RefSeq	YP_001301061.1. NC_009614.1.
3D structure databases
ProteinModelPortal	A6L6X5.
ModBase	Search...
Protein-protein interaction databases
STRING	A6L6X5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5304787.
GenomeReviews	Gene locus BVU_3828 in contig CP000139_GR.
KEGG	bvu:BVU_3828.
NMPDR	fig|435590.6.peg.3552.
PATRIC	21072736. VBIBacVul85104_3938.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	GYPLHGQ.
ProtClustDB	PRK00389.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_BACV8

Accession

Primary (citable) accession number: A6L6X5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program