Reviewed, UniProtKB/Swiss-Prot A6L6X1 (PTH_BACV8)

Names and origin

Protein names

Recommended name:
    Peptidyl-tRNA hydrolase
      Short name=PTH
    EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	BVU_3824

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity.
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_1000010563

Sequences

	Sequence		Length	Mass (Da)
	A6L6X1-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: DBA6E24703CDA61C	FASTA	187	20,617
	10 20 30 40 50 60 MKYLITGLGN IGEEYRNTRH NIGFTVLDAL AKASNLVFTD GRYGATATLS LKGRQLILLK 70 80 90 100 110 120 PSTYMNLSGN AVRYWMQKEN IPLENVLIVV DDLALPFGTL RLKGKGSDAG HNGLKHIAAT 130 140 150 160 170 180 LGTQDYARLR FGIGNDFPRG GQIDFVLGHF TDEDLKTMDE RVATACDIIK SFCLAGISIT MNQYNKK

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000139 Genomic DNA. Translation: ABR41435.1.
RefSeq	YP_001301057.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6L6X1.
Genome annotation databases
GeneID	5304783.
GenomeReviews	Gene locus BVU_3824 in contig CP000139_GR.
KEGG	bvu:BVU_3824.
NMPDR	fig|435590.6.peg.3548.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	IKFKTGG.
Family and domain databases
HAMAP	MF_00083. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
ProDom	PD005324. PeptRNAhydrolase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00447. pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_BACV8

Accession

Primary (citable) accession number: A6L6X1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)