A6L685 (MSCL_BACV8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel

Gene names

Name:	mscL
Ordered Locus Names:	BVU_3586

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115
Subunit structure	Homopentamer By similarity. HAMAP MF_00115
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00115.
Sequence similarities	Belongs to the MscL family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ionic channel
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 146	146	Large-conductance mechanosensitive channel HAMAP MF_00115		PRO_1000015353
Regions
	Transmembrane	12 – 32	21	Helical; Potential
	Transmembrane	83 – 103	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A6L685 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 0DF5C151CB64D858	FASTA	146	15,733
	10 20 30 40 50 60 MGKSSFLQDF KAFAMRGNVI DMAVGVIIGG AFGKIVSSIV ADVIMPPIGL LVGGVNFTDL 70 80 90 100 110 120 KLQLKPAEVV DGVEKAAVTL NYGNFLQATF DFIIIAFSIF LFIRLLAKLN RKKEEVPAPA 130 140 APPAPSKEEV LLTEIRDLLK EQAGKK

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000139 Genomic DNA. Translation: ABR41199.1.
RefSeq	YP_001300821.1. NC_009614.1.
3D structure databases
ProteinModelPortal	A6L685.
ModBase	Search...
Protein-protein interaction databases
STRING	A6L685.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5304546.
GenomeReviews	Gene locus BVU_3586 in contig CP000139_GR.
KEGG	bvu:BVU_3586.
NMPDR	fig|435590.6.peg.3334.
PATRIC	21072232. VBIBacVul85104_3686.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1970.
HOGENOM	HBG727604.
OMA	VIDFVIV.
ProtClustDB	PRK00567.
Family and domain databases
HAMAP	MF_00115. MscL. [Tree]
InterPro	IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view]
KO	K03282.
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
SUPFAM	SSF81330. MS_channel. 1 hit.
TIGRFAMs	TIGR00220. MscL. 1 hit.
PROSITE	PS01327. MSCL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSCL_BACV8

Accession

Primary (citable) accession number: A6L685

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program