Reviewed, UniProtKB/Swiss-Prot A6L5J9 (PYRB_BACV8)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BVU_3337

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Aspartate carbamoyltransferase		PRO_0000301555

Sequences

	Sequence		Length	Mass (Da)
	A6L5J9-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 8D6E99541031C8D1	FASTA	313	36,258
	10 20 30 40 50 60 MENRSLVTIA EHSKEKILYL LEMAKEFEKK PNRKILDGKV VATLFFEPST RTRLSFETAA 70 80 90 100 110 120 NRLGARVIGF TDPKVTSSSK GETLKDTIMM VSNYADIIVM RHFLEGAARY ASEVAPVPIV 130 140 150 160 170 180 NAGDGANQHP SQTMLDLYSI YKTQGTLENL NIYLVGDLKY GRTVHSLLMA MRHFNPTFHF 190 200 210 220 230 240 IAPEELKMPE EYKIYCKEHH IKYKEYTDFN EETIADADIL YMTRVQRERF TDLMEYERVK 250 260 270 280 290 300 DVYILRNKML EHTRPNLRIL HPLPRVNEIA YDVDENPKAY YFQQAQNGLY ARQAILCDVL 310 GITLNDVIED AKK

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000139 Genomic DNA. Translation: ABR40963.1.
RefSeq	YP_001300585.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5304298.
GenomeReviews	Gene locus BVU_3337 in contig CP000139_GR.
KEGG	bvu:BVU_3337.
NMPDR	fig|435590.6.peg.3111.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006130. Asp/Orn_carbamoyltranf. IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BACV8

Accession

Primary (citable) accession number: A6L5J9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 24, 2007
Last modified:	November 25, 2008
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)