Reviewed, UniProtKB/Swiss-Prot A6L5E2 (GCP_BACV8)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	BVU_3277

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303274
Sites
	Metal binding	111	1	Zinc Potential
	Metal binding	115	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	A6L5E2-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 76ED10AA440FEE80	FASTA	339	36,939
	10 20 30 40 50 60 MDTIILGIES SCDDTSAAVI KNGVLLSNVV SSQAVHEAYG GVVPELASRA HQQNIVPVVH 70 80 90 100 110 120 EALKRAGVTK EQLSAVAFTR GPGLMGSLLV GVSFAKGFAR SLNIPMIDVN HLQAHVLAHF 130 140 150 160 170 180 IKESEEDNNQ PKFPFLCLLV SGGNSQIILV KAYNDMEVLG QTIDDAAGEA IDKCSKVMGL 190 200 210 220 230 240 GYPGGPIIDK LARQGNPKAF TFSKPHIPDY NYSFSGLKTS FLYSLRDWLK EDPDFIEHHK 250 260 270 280 290 300 NDLAASLEAT IVDILMDKLR KAAKNLKINE VAVAGGVSAN NGLRNSFREH AGKYGWNIYI 310 320 330 PKFSFTTDNA AMIAITGYYK YLDNDFCTID KPAYSRVTI

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000139 Genomic DNA. Translation: ABR40906.1.
RefSeq	YP_001300528.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6L5E2.
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	5304238.
GenomeReviews	Gene locus BVU_3277 in contig CP000139_GR.
KEGG	bvu:BVU_3277.
NMPDR	fig|435590.6.peg.3056.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MEVIGQT.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_BACV8

Accession

Primary (citable) accession number: A6L5E2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 24, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)