A6L585 (SYD_BACV8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate--tRNA ligase
EC=6.1.1.12

Alternative name(s):
Aspartyl-tRNA synthetase
Short name=AspRS

Gene names

Name:	aspS
Ordered Locus Names:	BVU_3220

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	587 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP MF_00044_B
Subunit structure	Homodimer By similarity. HAMAP MF_00044_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00044_B.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tRNA aminoacylation for protein translation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW aspartate-tRNA ligase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 587	587	Aspartate--tRNA ligase HAMAP MF_00044_B		PRO_1000006637

Sequences

	Sequence		Length	Mass (Da)
	A6L585 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: FE78BF3AE8B8A99C	FASTA	587	66,451
	10 20 30 40 50 60 MFRSHTCGEL RLSDAGKSVT LAGWVQRARK MGGMTFVDLR DRYGITQLVF NEAVNAELCE 70 80 90 100 110 120 RANHLGREFV IQITGEVNER SNKNMNIPTG EIEIIVSVLN VLNSAVTPPF TIEDNSDGGD 130 140 150 160 170 180 DIRMKFRYLD LRRNCVRKNL ELRHKMTMEV RRYLDSKGFL EVETPMLVGS TPEGARDFVV 190 200 210 220 230 240 PSRMNPGQFY ALPQSPQTLK QLLMVSGFDR YFQIVKCFRD EDLRADRQPE FTQIDCEMSF 250 260 270 280 290 300 VEQEDIISTF EGMAKHLFKE LRGVELSEPF LRMTWADAIK YYGSDKPDLR FGMKFVELMD 310 320 330 340 350 360 IMKGHGFSVF DDAAYIGGIC AEGAASYTRK QLDQLTEFVK KPQIGAKGMV YARVEADGNV 370 380 390 400 410 420 KSSVDKFYSQ EVLQQMKEAF SAKPGDLILI LSGPDAMKTR KQLCELRLEV GRQLGLRDKN 430 440 450 460 470 480 KFACLWVVDF PMFEWSEEEG RLMAMHHPFT HPKEEDIPLL DTDPAAVRAD AYDMVVNGVE 490 500 510 520 530 540 VGGGSIRIHD SQLQAKMFEI LGFTPERAQE QFGFLMNAFK YGAPPHGGLA YGLDRWVSLF 550 560 570 580 AGLDSIRDCI AFPKNNSGRD VMLDAPAALD QSQLDELNLV VDIKEDK

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000139 Genomic DNA. Translation: ABR40849.1.
RefSeq	YP_001300471.1. NC_009614.1.
3D structure databases
ProteinModelPortal	A6L585.
ModBase	Search...
Protein-protein interaction databases
STRING	A6L585.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5304181.
GenomeReviews	Gene locus BVU_3220 in contig CP000139_GR.
KEGG	bvu:BVU_3220.
NMPDR	fig|435590.6.peg.3002.
PATRIC	21071462. VBIBacVul85104_3315.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0173.
HOGENOM	HBG396032.
OMA	AFPKTQQ.
ProtClustDB	PRK00476.
Family and domain databases
HAMAP	MF_00044_B. Asp_tRNA_synth_B. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II. IPR004524. Asp-tRNA-synth_IIb_bac/mt. IPR002312. Asp/Asn-tRNA-synth_IIb. IPR004115. GAD_dom. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR004365. NA-bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:3.30.1360.30. GAD_dom. 1 hit. G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KO	K01876.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF5. AspS_bac. 1 hit.
Pfam	PF02938. GAD. 1 hit. PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF55261. SSF55261. 1 hit.
TIGRFAMs	TIGR00459. AspS_bact. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYD_BACV8

Accession

Primary (citable) accession number: A6L585

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program