ID   UXAB_PHOV8              Reviewed;         479 AA.
AC   A6L4U5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   RecName: Full=Altronate oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00670};
DE            EC=1.1.1.58 {ECO:0000255|HAMAP-Rule:MF_00670};
DE   AltName: Full=Tagaturonate dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00670};
DE   AltName: Full=Tagaturonate reductase {ECO:0000255|HAMAP-Rule:MF_00670};
GN   Name=uxaB {ECO:0000255|HAMAP-Rule:MF_00670};
GN   OrderedLocusNames=BVU_3075;
OS   Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 /
OS   NBRC 14291 / NCTC 11154) (Bacteroides vulgatus).
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Phocaeicola.
OX   NCBI_TaxID=435590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 /
RC   NCTC 11154;
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-altronate + NAD(+) = H(+) + keto-D-tagaturonate + NADH;
CC         Xref=Rhea:RHEA:17813, ChEBI:CHEBI:15378, ChEBI:CHEBI:17360,
CC         ChEBI:CHEBI:17886, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.58;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00670};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00670}.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family. UxaB
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00670}.
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DR   EMBL; CP000139; ABR40709.1; -; Genomic_DNA.
DR   RefSeq; WP_005846561.1; NZ_JANSWM010000088.1.
DR   AlphaFoldDB; A6L4U5; -.
DR   SMR; A6L4U5; -.
DR   STRING; 435590.BVU_3075; -.
DR   PaxDb; 435590-BVU_3075; -.
DR   GeneID; 69841541; -.
DR   KEGG; bvu:BVU_3075; -.
DR   eggNOG; COG0246; Bacteria.
DR   HOGENOM; CLU_027324_1_0_10; -.
DR   BioCyc; BVUL435590:G1G59-3199-MONOMER; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002861; Chromosome.
DR   GO; GO:0009026; F:tagaturonate reductase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   HAMAP; MF_00670; Altron_oxidoreduct; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR023668; Altronate_OxRdtase.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR30524:SF0; ALTRONATE OXIDOREDUCTASE-RELATED; 1.
DR   PANTHER; PTHR30524; MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..479
FT                   /note="Altronate oxidoreductase"
FT                   /id="PRO_1000044700"
FT   BINDING         18..29
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00670"
SQ   SEQUENCE   479 AA;  53904 MW;  3D62C2A140C6764E CRC64;
     MKALNKETAA KTQRPERIIQ FGEGNFLRAF VDWIIYNMNE KTDFNSSVVV VQPIEKGMVD
     MLNAQDCLYH VNLQGLDKGQ VVNSLTKIDV ISRALNPYSQ NDEFMKLAEQ PEMRFVISNT
     TEAGIAFDPA CKLDDAPASS YPGKLTQLLY HRYKTFNGDK SKGLIIFPCE LIFLNGHKLK
     ETIYQYIDLW NLGEDFKQWF EEACGVYATL VDRIVPGFPR KDIAAIKEKL QYDDNLVVQA
     EIFHLWVIEA PQEVAKEFPA DKAGLNVLFV PSEAPYHERK VTLLNGPHTV LSPVAYLSGI
     NIVREACEHE VVGKYIHKVM FDELMETLNL PKEELKKFAE DVLERFNNPF VDHQVTSIML
     NSFPKYETRD LPGLKVYLER KGELPKGLVL GLAAIITYYK GGVRADGAEI VPNDAPEIMN
     LLKELWATGC TQKVAEGVLA AESIWGENLN NIPGLTAAVK ADLDSIQEKG MLETVKGIL
//