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A6L4U5 (UXAB_BACV8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Altronate oxidoreductase
EC=1.1.1.58
Alternative name(s):
Tagaturonate dehydrogenase
Tagaturonate reductase
Gene names
Name:uxaB
Ordered Locus Names:BVU_3075
OrganismBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]
Taxonomic identifier435590 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides ›

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP-Rule MF_00670

Pathway

Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP-Rule MF_00670

Sequence similarities

Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

nucleotide binding

Inferred from electronic annotation. Source: InterPro

tagaturonate reductase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Altronate oxidoreductase HAMAP-Rule MF_00670
PRO_1000044700

Regions

Nucleotide binding18 – 2912NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A6L4U5 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 3D62C2A140C6764E

FASTA47953,904
        10         20         30         40         50         60 
MKALNKETAA KTQRPERIIQ FGEGNFLRAF VDWIIYNMNE KTDFNSSVVV VQPIEKGMVD 

        70         80         90        100        110        120 
MLNAQDCLYH VNLQGLDKGQ VVNSLTKIDV ISRALNPYSQ NDEFMKLAEQ PEMRFVISNT 

       130        140        150        160        170        180 
TEAGIAFDPA CKLDDAPASS YPGKLTQLLY HRYKTFNGDK SKGLIIFPCE LIFLNGHKLK 

       190        200        210        220        230        240 
ETIYQYIDLW NLGEDFKQWF EEACGVYATL VDRIVPGFPR KDIAAIKEKL QYDDNLVVQA 

       250        260        270        280        290        300 
EIFHLWVIEA PQEVAKEFPA DKAGLNVLFV PSEAPYHERK VTLLNGPHTV LSPVAYLSGI 

       310        320        330        340        350        360 
NIVREACEHE VVGKYIHKVM FDELMETLNL PKEELKKFAE DVLERFNNPF VDHQVTSIML 

       370        380        390        400        410        420 
NSFPKYETRD LPGLKVYLER KGELPKGLVL GLAAIITYYK GGVRADGAEI VPNDAPEIMN 

       430        440        450        460        470 
LLKELWATGC TQKVAEGVLA AESIWGENLN NIPGLTAAVK ADLDSIQEKG MLETVKGIL

« Hide

References

[1]"Evolution of symbiotic bacteria in the distal human intestine."
Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I.
PLoS Biol. 5:1574-1586(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000139 Genomic DNA. Translation: ABR40709.1.
RefSeqYP_001300331.1. NC_009614.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING435590.BVU_3075.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR40709; ABR40709; BVU_3075.
GeneID5304036.
KEGGbvu:BVU_3075.
PATRIC21071168. VBIBacVul85104_3172.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHOG000029586.
KOK00041.
OMAHNTFCST.
ProtClustDBPRK03643.

Enzyme and pathway databases

BioCycBVUL435590:GH96-3094-MONOMER.
UniPathwayUPA00246.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPMF_00670. Altron_oxidoreduct.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR023668. Altronate_OxRdtase.
IPR013328. DH_multihelical.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUXAB_BACV8
AccessionPrimary (citable) accession number: A6L4U5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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