Reviewed, UniProtKB/Swiss-Prot A6L4U5 (UXAB_BACV8)

Names and origin

Protein names

Recommended name:
    Altronate oxidoreductase
    EC=1.1.1.58
Alternative name(s):
    Tagaturonate reductase
    Tagaturonate dehydrogenase

Gene names

Name:	uxaB
Ordered Locus Names:	BVU_3075

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP MF_00670
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00670
Sequence similarities	Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro tagaturonate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Altronate oxidoreductase HAMAP MF_00670		PRO_1000044700
Regions
	Nucleotide binding	18 – 29	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6L4U5-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 3D62C2A140C6764E	FASTA	479	53,904
	10 20 30 40 50 60 MKALNKETAA KTQRPERIIQ FGEGNFLRAF VDWIIYNMNE KTDFNSSVVV VQPIEKGMVD 70 80 90 100 110 120 MLNAQDCLYH VNLQGLDKGQ VVNSLTKIDV ISRALNPYSQ NDEFMKLAEQ PEMRFVISNT 130 140 150 160 170 180 TEAGIAFDPA CKLDDAPASS YPGKLTQLLY HRYKTFNGDK SKGLIIFPCE LIFLNGHKLK 190 200 210 220 230 240 ETIYQYIDLW NLGEDFKQWF EEACGVYATL VDRIVPGFPR KDIAAIKEKL QYDDNLVVQA 250 260 270 280 290 300 EIFHLWVIEA PQEVAKEFPA DKAGLNVLFV PSEAPYHERK VTLLNGPHTV LSPVAYLSGI 310 320 330 340 350 360 NIVREACEHE VVGKYIHKVM FDELMETLNL PKEELKKFAE DVLERFNNPF VDHQVTSIML 370 380 390 400 410 420 NSFPKYETRD LPGLKVYLER KGELPKGLVL GLAAIITYYK GGVRADGAEI VPNDAPEIMN 430 440 450 460 470 LLKELWATGC TQKVAEGVLA AESIWGENLN NIPGLTAAVK ADLDSIQEKG MLETVKGIL

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000139 Genomic DNA. Translation: ABR40709.1.
RefSeq	YP_001300331.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6L4U5.
Genome annotation databases
GeneID	5304036.
GenomeReviews	Gene locus BVU_3075 in contig CP000139_GR.
KEGG	bvu:BVU_3075.
NMPDR	fig|435590.6.peg.2879.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0246.
HOGENOM	HBG297101.
OMA	SIFPCEL.
Family and domain databases
HAMAP	MF_00670. Altron_oxidoreduct. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UXAB_BACV8

Accession

Primary (citable) accession number: A6L4U5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	January 19, 2010
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)