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A6L4P0 (FTHS_BACV8) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:BVU_3016
OrganismBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]
Taxonomic identifier435590 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000300516

Regions

Nucleotide binding64 – 718ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A6L4P0 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 771F49D9C92B5CE4

FASTA55560,524
        10         20         30         40         50         60 
MKTDIEIARS IELVKIKQVA RETGIPVEHI SNYGRYIAKV DESQINEEKV QQSNLILVTA 

        70         80         90        100        110        120 
ITPTKAGIGK TTVSIGLALG LNKIGKKTIV ALREPSLGPC FGMKGGAAGG GYAQVLPMDK 

       130        140        150        160        170        180 
INLHFTGDFH AITSAHNMIS ALLDNYLYQN RDNGFGLKEV LWRRVLDVND RSLRYIVTGL 

       190        200        210        220        230        240 
GPKTNGITQE SGFDITPASE IMAILCLAKD EKDLRRRIEN ILLGFTYDNK PFTVKDLGVA 

       250        260        270        280        290        300 
GAITVLLKDA LSPNLVQTTE HTAAFVHGGP FANIAHGCNS ILATKMAMTF SDYTITEAGF 

       310        320        330        340        350        360 
GADLGAEKFY DIKCRKAGVT PKLTVLVVTA RALKMHGGVS QDKIKEPNLE ALKQGVANMD 

       370        380        390        400        410        420 
KHLRNLRYFG QTVVVAFNRY GDDSEEEVDY IRTHCEKKGV GFAVNNAFTD GGEGAVELAE 

       430        440        450        460        470        480 
LVVKTIEEQP SEPLQYAYDD EDSVETKISK VACNLYGASI ITYSAAARKK LKHIVELGYG 

       490        500        510        520        530        540 
NFPICIAKTQ YSFSTDPKIY GAVDNFEFHV QDIVMNAGAE MLVVIAGEIM RMPGLPKEPQ 

       550 
ALHIDIVNGE IEGLS 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000139 Genomic DNA. Translation: ABR40654.1.
RefSeqYP_001300276.1. NC_009614.1.

3D structure databases

ProteinModelPortalA6L4P0.
SMRA6L4P0. Positions 4-553.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING435590.BVU_3016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR40654; ABR40654; BVU_3016.
GeneID5303977.
KEGGbvu:BVU_3016.
PATRIC21071038. VBIBacVul85104_3111.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycBVUL435590:GH96-3008-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_BACV8
AccessionPrimary (citable) accession number: A6L4P0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways