Reviewed, UniProtKB/Swiss-Prot A6L4P0 (FTHS_BACV8)

Names and origin

Protein names

Recommended name:
    Formate--tetrahydrofolate ligase
    EC=6.3.4.3
Alternative name(s):
    Formyltetrahydrofolate synthetase
      Short name=FHS
      Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	BVU_3016

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid and derivative biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	Formate--tetrahydrofolate ligase HAMAP MF_01543		PRO_0000300516
Regions
	Nucleotide binding	64 – 71	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6L4P0-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 771F49D9C92B5CE4	FASTA	555	60,524
	10 20 30 40 50 60 MKTDIEIARS IELVKIKQVA RETGIPVEHI SNYGRYIAKV DESQINEEKV QQSNLILVTA 70 80 90 100 110 120 ITPTKAGIGK TTVSIGLALG LNKIGKKTIV ALREPSLGPC FGMKGGAAGG GYAQVLPMDK 130 140 150 160 170 180 INLHFTGDFH AITSAHNMIS ALLDNYLYQN RDNGFGLKEV LWRRVLDVND RSLRYIVTGL 190 200 210 220 230 240 GPKTNGITQE SGFDITPASE IMAILCLAKD EKDLRRRIEN ILLGFTYDNK PFTVKDLGVA 250 260 270 280 290 300 GAITVLLKDA LSPNLVQTTE HTAAFVHGGP FANIAHGCNS ILATKMAMTF SDYTITEAGF 310 320 330 340 350 360 GADLGAEKFY DIKCRKAGVT PKLTVLVVTA RALKMHGGVS QDKIKEPNLE ALKQGVANMD 370 380 390 400 410 420 KHLRNLRYFG QTVVVAFNRY GDDSEEEVDY IRTHCEKKGV GFAVNNAFTD GGEGAVELAE 430 440 450 460 470 480 LVVKTIEEQP SEPLQYAYDD EDSVETKISK VACNLYGASI ITYSAAARKK LKHIVELGYG 490 500 510 520 530 540 NFPICIAKTQ YSFSTDPKIY GAVDNFEFHV QDIVMNAGAE MLVVIAGEIM RMPGLPKEPQ 550 ALHIDIVNGE IEGLS

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000139 Genomic DNA. Translation: ABR40654.1.
RefSeq	YP_001300276.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6L4P0.
Genome annotation databases
GeneID	5303977.
GenomeReviews	Gene locus BVU_3016 in contig CP000139_GR.
KEGG	bvu:BVU_3016.
NMPDR	fig|435590.6.peg.2824.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	GMKGGAT.
Family and domain databases
HAMAP	MF_01543. [Tree]
InterPro	IPR000559. For_THF_ligase. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_BACV8

Accession

Primary (citable) accession number: A6L4P0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 24, 2007
Last modified:	November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)