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A6L4P0

- FTHS_BACV8

UniProt

A6L4P0 - FTHS_BACV8

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBVUL435590:GH96-3008-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:BVU_3016
    OrganismiBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
    Taxonomic identifieri435590 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000002861: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000300516Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi435590.BVU_3016.

    Structurei

    3D structure databases

    ProteinModelPortaliA6L4P0.
    SMRiA6L4P0. Positions 4-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6L4P0-1 [UniParc]FASTAAdd to Basket

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    MKTDIEIARS IELVKIKQVA RETGIPVEHI SNYGRYIAKV DESQINEEKV    50
    QQSNLILVTA ITPTKAGIGK TTVSIGLALG LNKIGKKTIV ALREPSLGPC 100
    FGMKGGAAGG GYAQVLPMDK INLHFTGDFH AITSAHNMIS ALLDNYLYQN 150
    RDNGFGLKEV LWRRVLDVND RSLRYIVTGL GPKTNGITQE SGFDITPASE 200
    IMAILCLAKD EKDLRRRIEN ILLGFTYDNK PFTVKDLGVA GAITVLLKDA 250
    LSPNLVQTTE HTAAFVHGGP FANIAHGCNS ILATKMAMTF SDYTITEAGF 300
    GADLGAEKFY DIKCRKAGVT PKLTVLVVTA RALKMHGGVS QDKIKEPNLE 350
    ALKQGVANMD KHLRNLRYFG QTVVVAFNRY GDDSEEEVDY IRTHCEKKGV 400
    GFAVNNAFTD GGEGAVELAE LVVKTIEEQP SEPLQYAYDD EDSVETKISK 450
    VACNLYGASI ITYSAAARKK LKHIVELGYG NFPICIAKTQ YSFSTDPKIY 500
    GAVDNFEFHV QDIVMNAGAE MLVVIAGEIM RMPGLPKEPQ ALHIDIVNGE 550
    IEGLS 555
    Length:555
    Mass (Da):60,524
    Last modified:July 24, 2007 - v1
    Checksum:i771F49D9C92B5CE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000139 Genomic DNA. Translation: ABR40654.1.
    RefSeqiWP_005846873.1. NC_009614.1.
    YP_001300276.1. NC_009614.1.

    Genome annotation databases

    EnsemblBacteriaiABR40654; ABR40654; BVU_3016.
    GeneIDi5303977.
    KEGGibvu:BVU_3016.
    PATRICi21071038. VBIBacVul85104_3111.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000139 Genomic DNA. Translation: ABR40654.1 .
    RefSeqi WP_005846873.1. NC_009614.1.
    YP_001300276.1. NC_009614.1.

    3D structure databases

    ProteinModelPortali A6L4P0.
    SMRi A6L4P0. Positions 4-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 435590.BVU_3016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR40654 ; ABR40654 ; BVU_3016 .
    GeneIDi 5303977.
    KEGGi bvu:BVU_3016.
    PATRICi 21071038. VBIBacVul85104_3111.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci BVUL435590:GH96-3008-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

    Entry informationi

    Entry nameiFTHS_BACV8
    AccessioniPrimary (citable) accession number: A6L4P0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3