A6L3D0 (AROC_BACV8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	BVU_2537

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Chorismate synthase HAMAP MF_00300		PRO_1000022460

Sequences

	Sequence		Length	Mass (Da)
	A6L3D0 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 237F36E0CE5B0DCA	FASTA	358	39,167
	10 20 30 40 50 60 MFNSFGNIFR LTSFGESHGP GVGGVIDGFP AGIKIDMDFV QQELNRRRPG QSLLTTSRKE 70 80 90 100 110 120 PDTVEFLSGI FEGKSTGCPI GFVVWNKNQH SNDYENIKNL FRPSHADYTY MQKYGIRDYR 130 140 150 160 170 180 GGGRSSARET ISRVVAGALA KLALKQLGIS VTAYTSQVGP VKLDKDYKSY NLDLIETNDV 190 200 210 220 230 240 RCPDPEKAKE MAELIWKIKG EGDTIGGVVS CVIKGCPIGL GQPVFGKLHA ALGNAMLSIN 250 260 270 280 290 300 AVKGFSYGQG FDSMELKGSE QNDVFYNNNG RVETKSNYSG GIQGGISNGQ DIYFRVAFKP 310 320 330 340 350 VATILMEQHT VNINGTDTTM KAKGRHDACV LPRAVPIVEA MAAMTILDYY LIDRTTQL

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000139 Genomic DNA. Translation: ABR40194.1.
RefSeq	YP_001299816.1. NC_009614.1.
3D structure databases
ProteinModelPortal	A6L3D0.
ModBase	Search...
Protein-protein interaction databases
STRING	A6L3D0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5303501.
GenomeReviews	Gene locus BVU_2537 in contig CP000139_GR.
KEGG	bvu:BVU_2537.
NMPDR	fig|435590.6.peg.2379.
PATRIC	21070026. VBIBacVul85104_2618.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0082.
HOGENOM	HBG292336.
OMA	SRFTTQR.
ProtClustDB	PRK05382.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_BACV8

Accession

Primary (citable) accession number: A6L3D0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program