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A6L313

- MEND_BACV8

UniProt

A6L313 - MEND_BACV8

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Protein
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
Gene
menD, BVU_2418
Organism
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) By similarity.UniRule annotation

Catalytic activityi

Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotation

Cofactori

Magnesium or manganese By similarity.UniRule annotation
Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathwayi

GO - Molecular functioni

  1. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
  3. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Menaquinone biosynthesis

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBVUL435590:GH96-2413-MONOMER.
UniPathwayiUPA00079; UER00164.

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (EC:2.2.1.9)
Short name:
SEPHCHC synthase
Alternative name(s):
Menaquinone biosynthesis protein MenD
Gene namesi
Name:menD
Ordered Locus Names:BVU_2418
OrganismiBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
Taxonomic identifieri435590 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000002861: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5575572-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotation
PRO_0000341717Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi435590.BVU_2418.

Structurei

3D structure databases

ProteinModelPortaliA6L313.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1165.
HOGENOMiHOG000218359.
KOiK02551.
OMAiFEMASNI.
OrthoDBiEOG6NWBQW.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01659. MenD.
InterProiIPR004433. MenaQ_synth_MenD.
IPR029061. THDP-binding.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
[Graphical view]
PfamiPF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
PIRSFiPIRSF004983. MenD. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00173. menD. 1 hit.

Sequencei

Sequence statusi: Complete.

A6L313-1 [UniParc]FASTAAdd to Basket

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MYSDKKNILQ LVALLKAHGV RKIVLCPGSR NAAIVHTLAN IEDFTCYSVT    50
DERSAGFFAI GLSLQGGGPA AVCCTSGSAL LNLHPAVAEA FYQQVPLIVI 100
SADRPAAWIG QMDGQTLPQP HVFGTLVKMS VNLPEVHTEE DEWFCNRLIN 150
EAILETTHHG KGPVHINVPI SEPIYRFTAK TLPEVRVITR YQGLSVYDRD 200
YKELIERLNK YNKRMVVVGQ MNLIYLFEKK YVKPLYKHFA WLTEHLGNQT 250
IPGIPIKNFD AAVYSMTPER QEDMAPEILI TYGGHIVSKQ LKKYLRNHPP 300
REHWHVAADG KIADLYGCLT TVIEMDPFEF LEKIAFLLDN KPTHYPLMWE 350
NYCKTIPMPD LAYSEISVIG KLIRALPEPC ALHLANSSTV RYAQLFTVPP 400
QVEICCNRGV NGIEGSLSTA IGYAAASSKL NFIIIGDLSF FYDMNALWNQ 450
NYGANIRILL LNNEGGEIFH TLPGMDKSSR SREFITAEHY TTAKGWAEER 500
GFIYMKVTGE EELEEAMQPF TSPETRMQPM LLEVFTDKEK DTTLLREYYH 550
GLKNKNE 557
Length:557
Mass (Da):62,971
Last modified:July 24, 2007 - v1
Checksum:i440921E36AAB4DB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000139 Genomic DNA. Translation: ABR40077.1.
RefSeqiYP_001299699.1. NC_009614.1.

Genome annotation databases

EnsemblBacteriaiABR40077; ABR40077; BVU_2418.
GeneIDi5303382.
KEGGibvu:BVU_2418.
PATRICi21069786. VBIBacVul85104_2500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000139 Genomic DNA. Translation: ABR40077.1 .
RefSeqi YP_001299699.1. NC_009614.1.

3D structure databases

ProteinModelPortali A6L313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 435590.BVU_2418.

Protocols and materials databases

DNASUi 5303382.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR40077 ; ABR40077 ; BVU_2418 .
GeneIDi 5303382.
KEGGi bvu:BVU_2418.
PATRICi 21069786. VBIBacVul85104_2500.

Phylogenomic databases

eggNOGi COG1165.
HOGENOMi HOG000218359.
KOi K02551.
OMAi FEMASNI.
OrthoDBi EOG6NWBQW.

Enzyme and pathway databases

UniPathwayi UPA00079 ; UER00164 .
BioCyci BVUL435590:GH96-2413-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01659. MenD.
InterProi IPR004433. MenaQ_synth_MenD.
IPR029061. THDP-binding.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
[Graphical view ]
Pfami PF02776. TPP_enzyme_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF004983. MenD. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00173. menD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Entry informationi

Entry nameiMEND_BACV8
AccessioniPrimary (citable) accession number: A6L313
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 24, 2007
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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