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A6L2V6

- HIS1_BACV8

UniProt

A6L2V6 - HIS1_BACV8

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Protein
ATP phosphoribosyltransferase
Gene
hisG, BVU_2361
Organism
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Enzyme regulationi

Feedback inhibited by histidine By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP phosphoribosyltransferase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBVUL435590:GH96-2356-MONOMER.
UniPathwayiUPA00031; UER00006.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase (EC:2.4.2.17)
Short name:
ATP-PRT
Short name:
ATP-PRTase
Gene namesi
Name:hisG
Ordered Locus Names:BVU_2361
OrganismiBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
Taxonomic identifieri435590 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000002861: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283ATP phosphoribosyltransferaseUniRule annotation
PRO_1000004444Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi435590.BVU_2361.

Structurei

3D structure databases

ProteinModelPortaliA6L2V6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0040.
HOGENOMiHOG000223247.
KOiK00765.
OMAiTRMQGVI.
OrthoDBiEOG66MQT3.

Family and domain databases

Gene3Di3.30.70.120. 1 hit.
HAMAPiMF_00079. HisG_Long.
InterProiIPR013820. ATP_PRibTrfase_cat.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
PANTHERiPTHR21403. PTHR21403. 1 hit.
PfamiPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMiSSF54913. SSF54913. 1 hit.
TIGRFAMsiTIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.

Sequencei

Sequence statusi: Complete.

A6L2V6-1 [UniParc]FASTAAdd to Basket

« Hide

MLRIAVQSKG RLFEETMALL QEADIKISTS KRILLVQSSN FPIEVLFLRD    50
DDIPQSVAGG VADLGIVGEN EFVERKEDAE VIKRLGFSKC RLSLAIPKDV 100
DYPGLSWFEG RKIATSYPGI LKDFMDRNGI HSDIHVITGS VEIAPGISLA 150
DAIFDIVSSG STLVSNSLKE VEVVMKSEAL LIGNKNMSEE KKEILNELLF 200
RIEAVKAAED KKYVLMNAPT ERLKEIIEVL PGMKSPTVMP LAQEGWSSVH 250
TVLDEKRFWE IIGKLKALGA EGILVLPIEK MIL 283
Length:283
Mass (Da):31,335
Last modified:July 24, 2007 - v1
Checksum:i5E768F192A61CB82
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000139 Genomic DNA. Translation: ABR40020.1.
RefSeqiYP_001299642.1. NC_009614.1.

Genome annotation databases

EnsemblBacteriaiABR40020; ABR40020; BVU_2361.
GeneIDi5303325.
KEGGibvu:BVU_2361.
PATRICi21069662. VBIBacVul85104_2438.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000139 Genomic DNA. Translation: ABR40020.1 .
RefSeqi YP_001299642.1. NC_009614.1.

3D structure databases

ProteinModelPortali A6L2V6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 435590.BVU_2361.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR40020 ; ABR40020 ; BVU_2361 .
GeneIDi 5303325.
KEGGi bvu:BVU_2361.
PATRICi 21069662. VBIBacVul85104_2438.

Phylogenomic databases

eggNOGi COG0040.
HOGENOMi HOG000223247.
KOi K00765.
OMAi TRMQGVI.
OrthoDBi EOG66MQT3.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00006 .
BioCyci BVUL435590:GH96-2356-MONOMER.

Family and domain databases

Gene3Di 3.30.70.120. 1 hit.
HAMAPi MF_00079. HisG_Long.
InterProi IPR013820. ATP_PRibTrfase_cat.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view ]
PANTHERi PTHR21403. PTHR21403. 1 hit.
Pfami PF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view ]
SUPFAMi SSF54913. SSF54913. 1 hit.
TIGRFAMsi TIGR00070. hisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Entry informationi

Entry nameiHIS1_BACV8
AccessioniPrimary (citable) accession number: A6L2V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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