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A6L2V6

- HIS1_BACV8

UniProt

A6L2V6 - HIS1_BACV8

Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Enzyme regulationi

    Feedback inhibited by histidine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP phosphoribosyltransferase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBVUL435590:GH96-2356-MONOMER.
    UniPathwayiUPA00031; UER00006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
    Short name:
    ATP-PRTUniRule annotation
    Short name:
    ATP-PRTaseUniRule annotation
    Gene namesi
    Name:hisGUniRule annotation
    Ordered Locus Names:BVU_2361
    OrganismiBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
    Taxonomic identifieri435590 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000002861: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283ATP phosphoribosyltransferasePRO_1000004444Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi435590.BVU_2361.

    Structurei

    3D structure databases

    ProteinModelPortaliA6L2V6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP phosphoribosyltransferase family. Long subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0040.
    HOGENOMiHOG000223247.
    KOiK00765.
    OMAiTRMQGVI.
    OrthoDBiEOG66MQT3.

    Family and domain databases

    Gene3Di3.30.70.120. 1 hit.
    HAMAPiMF_00079. HisG_Long.
    InterProiIPR013820. ATP_PRibTrfase_cat.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR020621. ATP_PRibTrfase_HisG_long.
    IPR013115. HisG_C.
    IPR011322. N-reg_PII-like_a/b.
    IPR015867. N-reg_PII/ATP_PRibTrfase_C.
    [Graphical view]
    PANTHERiPTHR21403. PTHR21403. 1 hit.
    PfamiPF01634. HisG. 1 hit.
    PF08029. HisG_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54913. SSF54913. 1 hit.
    TIGRFAMsiTIGR00070. hisG. 1 hit.
    TIGR03455. HisG_C-term. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6L2V6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRIAVQSKG RLFEETMALL QEADIKISTS KRILLVQSSN FPIEVLFLRD    50
    DDIPQSVAGG VADLGIVGEN EFVERKEDAE VIKRLGFSKC RLSLAIPKDV 100
    DYPGLSWFEG RKIATSYPGI LKDFMDRNGI HSDIHVITGS VEIAPGISLA 150
    DAIFDIVSSG STLVSNSLKE VEVVMKSEAL LIGNKNMSEE KKEILNELLF 200
    RIEAVKAAED KKYVLMNAPT ERLKEIIEVL PGMKSPTVMP LAQEGWSSVH 250
    TVLDEKRFWE IIGKLKALGA EGILVLPIEK MIL 283
    Length:283
    Mass (Da):31,335
    Last modified:July 24, 2007 - v1
    Checksum:i5E768F192A61CB82
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000139 Genomic DNA. Translation: ABR40020.1.
    RefSeqiYP_001299642.1. NC_009614.1.

    Genome annotation databases

    EnsemblBacteriaiABR40020; ABR40020; BVU_2361.
    GeneIDi5303325.
    KEGGibvu:BVU_2361.
    PATRICi21069662. VBIBacVul85104_2438.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000139 Genomic DNA. Translation: ABR40020.1 .
    RefSeqi YP_001299642.1. NC_009614.1.

    3D structure databases

    ProteinModelPortali A6L2V6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 435590.BVU_2361.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR40020 ; ABR40020 ; BVU_2361 .
    GeneIDi 5303325.
    KEGGi bvu:BVU_2361.
    PATRICi 21069662. VBIBacVul85104_2438.

    Phylogenomic databases

    eggNOGi COG0040.
    HOGENOMi HOG000223247.
    KOi K00765.
    OMAi TRMQGVI.
    OrthoDBi EOG66MQT3.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00006 .
    BioCyci BVUL435590:GH96-2356-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.120. 1 hit.
    HAMAPi MF_00079. HisG_Long.
    InterProi IPR013820. ATP_PRibTrfase_cat.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR020621. ATP_PRibTrfase_HisG_long.
    IPR013115. HisG_C.
    IPR011322. N-reg_PII-like_a/b.
    IPR015867. N-reg_PII/ATP_PRibTrfase_C.
    [Graphical view ]
    PANTHERi PTHR21403. PTHR21403. 1 hit.
    Pfami PF01634. HisG. 1 hit.
    PF08029. HisG_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54913. SSF54913. 1 hit.
    TIGRFAMsi TIGR00070. hisG. 1 hit.
    TIGR03455. HisG_C-term. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

    Entry informationi

    Entry nameiHIS1_BACV8
    AccessioniPrimary (citable) accession number: A6L2V6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3