Reviewed, UniProtKB/Swiss-Prot A6L2R5 (ARAA_BACV8)

Names and origin

Protein names

Recommended name:
    L-arabinose isomerase
    EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	BVU_2320

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity.
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity.
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 509	509	L-arabinose isomerase HAMAP MF_00519		PRO_0000312602
Sites
	Metal binding	313	1	Manganese By similarity
	Metal binding	340	1	Manganese By similarity
	Metal binding	357	1	Manganese By similarity
	Metal binding	456	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6L2R5-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: AED636EE8F09096F	FASTA	509	57,215
	10 20 30 40 50 60 MEKAFDQYEV WFVTGAQLLY GGDAVIAVDA HSNEMVNGLN ESGKLPVKVV YKGTANSSKE 70 80 90 100 110 120 VEAVFKAANN DEKCIGVITW MHTFSPAKMW IHGLQQLKKP LLHLHTQFNK EIPWDTMDMD 130 140 150 160 170 180 FMNLNQSAHG DREFGHICTR MRIRRKVVVG YWKDEDTQHK IAVWMRVCAG WADSQDMLII 190 200 210 220 230 240 RFGDQMNNVA VTDGDKVEAE QRMGYHVDYC PASELMKYHK NIKDTDVEAL VATYFNEYDH 250 260 270 280 290 300 DASLEDKSTE AYQKVWNAAK AELALRAILK AKGAKGFTTN FDDLGQTDGS YFDQIPGLAS 310 320 330 340 350 360 QRLMAEGYGF GAEGDWKSAA LYRTVWVMNQ GLSKGCSFLE DYTLNFDGAN SAILQSHMLE 370 380 390 400 410 420 VCPLIAASKP RLEVHFLGIG IRKSQTARLV FTSKVGSGCT ATVVDLGNRF RLIVNDVECI 430 440 450 460 470 480 ESKPLPKLPV ASALWIPMPN FEVGAGAWIL AGGTHHSCFS YDLTAEYWED YAEIAGIEMI 490 500 RIDKDTTISN FKKELRMNEV YYMLNKALC

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000139 Genomic DNA. Translation: ABR39979.1.
RefSeq	YP_001299601.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6L2R5.
Genome annotation databases
GeneID	5303284.
GenomeReviews	Gene locus BVU_2320 in contig CP000139_GR.
KEGG	bvu:BVU_2320.
NMPDR	fig|435590.6.peg.2177.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	IASESIK.
Family and domain databases
HAMAP	MF_00519. [Tree]
InterPro	IPR003762. Lara_isomerase. [Graphical view]
Pfam	PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

ARAA_BACV8

Accession

Primary (citable) accession number: A6L2R5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	July 24, 2007
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)