A6L1J5 (PSD_BACV8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

1. Phosphatidylserine decarboxylase alpha chain
2. Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	BVU_1884

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664
Cofactor	Pyruvoyl group By similarity. HAMAP MF_00664
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	Phosphatidylserine decarboxylase beta chain By similarity		PRO_1000026622
	Chain	197 – 228	32	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_1000026623
Sites
	Site	196 – 197	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	197	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6L1J5 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: E90DAFC335494462	FASTA	228	25,955
	10 20 30 40 50 60 MNRLKKLKKI RLHREGTSIL IVSAILLIGI NALLFWGIEC KIPFYIFATA SIVVYLLMVN 70 80 90 100 110 120 FFRCPIRLFE HDTEKIVVAP ADGRIVVIEE VDEHEYFHDR RLMISIFMSI VNVHANWYPV 130 140 150 160 170 180 DGVVKHVDHH NGKFMKAWLP KASTENERSM VVIETPEGHT VMARQIAGAI ARRIVTYAEV 190 200 210 220 GEDCYIDEHM GFIKFGSRVD VYLPLGTEVC VKMGQATVGN ETVIAKLK

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000139 Genomic DNA. Translation: ABR39559.1.
RefSeq	YP_001299181.1. NC_009614.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6L1J5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5302850.
GenomeReviews	Gene locus BVU_1884 in contig CP000139_GR.
KEGG	bvu:BVU_1884.
NMPDR	fig|435590.6.peg.1773.
PATRIC	21068666. VBIBacVul85104_1952.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0688.
HOGENOM	HBG541103.
OMA	NERVVWH.
ProtClustDB	PRK05305.
Family and domain databases
HAMAP	MF_00664. PS_decarb_type3. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR004428. PtdSer_deCO2ase-related. [Graphical view]
KO	K01613.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_BACV8

Accession

Primary (citable) accession number: A6L1J5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program