Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A6L1E7

- KITH_BACV8

UniProt

A6L1E7 - KITH_BACV8

Protein

Thymidine kinase

Gene

tdk

Organism
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei96 – 961Proton acceptorUniRule annotation
    Metal bindingi152 – 1521ZincUniRule annotation
    Metal bindingi155 – 1551ZincUniRule annotation
    Metal bindingi184 – 1841ZincUniRule annotation
    Metal bindingi187 – 1871ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 308ATPUniRule annotation
    Nucleotide bindingi95 – 984ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciBVUL435590:GH96-1833-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:BVU_1836
    OrganismiBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
    Taxonomic identifieri435590 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000002861: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 199199Thymidine kinasePRO_1000018151Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi435590.BVU_1836.

    Structurei

    3D structure databases

    ProteinModelPortaliA6L1E7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiQAICLSC.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6L1E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVFSEDHIQ ETRRRGRIEV ICGSMFSGKT EELIRRLKRA KFARQRVEIF    50
    KPAIDTRYSE EEVVSHDSNS IASTPIDSSA SILLFSSDKD VVGIDEAQFF 100
    DEGLVDVCNK LADNGIRVIV AGLDMDFRRV PFGPIPALLA IADEVTKVHA 150
    ICVKCGNLAY ATHRITKSEK RVLLGEKADY EPLCRTCYME ALKEETENK 199
    Length:199
    Mass (Da):22,372
    Last modified:July 24, 2007 - v1
    Checksum:i5DCADD40923670E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000139 Genomic DNA. Translation: ABR39511.1.
    RefSeqiYP_001299133.1. NC_009614.1.

    Genome annotation databases

    EnsemblBacteriaiABR39511; ABR39511; BVU_1836.
    GeneIDi5302802.
    KEGGibvu:BVU_1836.
    PATRICi21068564. VBIBacVul85104_1901.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000139 Genomic DNA. Translation: ABR39511.1 .
    RefSeqi YP_001299133.1. NC_009614.1.

    3D structure databases

    ProteinModelPortali A6L1E7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 435590.BVU_1836.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR39511 ; ABR39511 ; BVU_1836 .
    GeneIDi 5302802.
    KEGGi bvu:BVU_1836.
    PATRICi 21068564. VBIBacVul85104_1901.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi QAICLSC.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci BVUL435590:GH96-1833-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

    Entry informationi

    Entry nameiKITH_BACV8
    AccessioniPrimary (citable) accession number: A6L1E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3