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A6L1E7 (KITH_BACV8) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:BVU_1836
OrganismBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]
Taxonomic identifier435590 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Thymidine kinase HAMAP-Rule MF_00124
PRO_1000018151

Regions

Nucleotide binding23 – 308ATP By similarity
Nucleotide binding95 – 984ATP By similarity

Sites

Active site961Proton acceptor Potential
Metal binding1521Zinc By similarity
Metal binding1551Zinc By similarity
Metal binding1841Zinc By similarity
Metal binding1871Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A6L1E7 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 5DCADD40923670E6

FASTA19922,372
        10         20         30         40         50         60 
MVVFSEDHIQ ETRRRGRIEV ICGSMFSGKT EELIRRLKRA KFARQRVEIF KPAIDTRYSE 

        70         80         90        100        110        120 
EEVVSHDSNS IASTPIDSSA SILLFSSDKD VVGIDEAQFF DEGLVDVCNK LADNGIRVIV 

       130        140        150        160        170        180 
AGLDMDFRRV PFGPIPALLA IADEVTKVHA ICVKCGNLAY ATHRITKSEK RVLLGEKADY 

       190 
EPLCRTCYME ALKEETENK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000139 Genomic DNA. Translation: ABR39511.1.
RefSeqYP_001299133.1. NC_009614.1.

3D structure databases

ProteinModelPortalA6L1E7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING435590.BVU_1836.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR39511; ABR39511; BVU_1836.
GeneID5302802.
KEGGbvu:BVU_1836.
PATRIC21068564. VBIBacVul85104_1901.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076390.
KOK00857.
OMAKVHAICV.
OrthoDBEOG69D3J2.
ProtClustDBPRK04296.

Enzyme and pathway databases

BioCycBVUL435590:GH96-1833-MONOMER.

Family and domain databases

HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_BACV8
AccessionPrimary (citable) accession number: A6L1E7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families