Reviewed, UniProtKB/Swiss-Prot A6L175 (DXS_BACV8)

Names and origin

Protein names

Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthase
    EC=2.2.1.7
Alternative name(s):
    1-deoxyxylulose-5-phosphate synthase
      Short name=DXP synthase
      Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	BVU_1763

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	632 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity.
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP thiamin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 632	632	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_1000019009

Sequences

	Sequence		Length	Mass (Da)
	A6L175-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 26E7D7DBB614F269	FASTA	632	70,235
	10 20 30 40 50 60 MEQDNLYNLL QSIDTPDDLR HLSADKLPEV CKELRQKIID ELSCNPGHFG SSLGVIELTV 70 80 90 100 110 120 ALHYVFNTPY DRIVWDVGHQ AYGHKILTGR RDAFCTNRKL NGIRPFPSPS ESEYDTFTCG 130 140 150 160 170 180 HASNSISAAL GMAVAAKKHG ENNRHVVAVI GDGSMSGGLA FEGLNNASAT PNNLLIILND 190 200 210 220 230 240 NNMAIDRSVG GMKQYLLNLQ MSEGYNRIRY KISQMFHRWG ILNEERRKSL IRFNNSLKSM 250 260 270 280 290 300 LVQQQNVFEG MNIRYFGPID GHDVNNLARV LKEIKDMQGP KLLHIHTTKG KGFGPAEKAA 310 320 330 340 350 360 TIWHAPGIFD KETGERIVVD TKGMPPLFQD VFGNTLLELA QTNDKIVGVT PAMPSGCSMN 370 380 390 400 410 420 ILMKAMPERG FDVGIAEGHA VTFSGGMAKD GLLPFCNIYS SFMQRAYDNV IHDIAIQKLN 430 440 450 460 470 480 VVLCLDRAGL VGEDGPTHHG AFDLAYMRPI PNLIVASPYN EHELRCLMYT AQLPDKGPFV 490 500 510 520 530 540 IRYPRGRGSL VDWKCPMQEI EIGKGRKLKE GKDIAVITLG PIGVQAEKAI THAEQETGKS 550 560 570 580 590 600 IAHYDLRFLK PLDESMLHEI GKRFKQVVTV EDGVLKGGMG SAILEFMADN EYNPQIKRIG 610 620 630 LPDQFVQHGS VKELYHICGM DEEGIYKVLI SF

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000139 Genomic DNA. Translation: ABR39439.1.
RefSeq	YP_001299061.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6L175.
Genome annotation databases
GeneID	5302729.
GenomeReviews	Gene locus BVU_1763 in contig CP000139_GR.
KEGG	bvu:BVU_1763.
NMPDR	fig|435590.6.peg.1659.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	QRFPDRY.
Family and domain databases
HAMAP	MF_00315. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00204. dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. False negative. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_BACV8

Accession

Primary (citable) accession number: A6L175

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)