A6L0U5 (SYN_BACV8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Asparagine--tRNA ligase
EC=6.1.1.22

Alternative name(s):
Asparaginyl-tRNA synthetase
Short name=AsnRS

Gene names

Name:	asnS
Ordered Locus Names:	BVU_1628

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). HAMAP MF_00534
Subunit structure	Homodimer By similarity. HAMAP MF_00534
Subcellular location	Cytoplasm HAMAP MF_00534.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	asparaginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW asparagine-tRNA ligase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Asparagine--tRNA ligase HAMAP MF_00534		PRO_1000051379

Sequences

	Sequence		Length	Mass (Da)
	A6L0U5 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 4BFE22AD69EAB7DA	FASTA	467	53,429
	10 20 30 40 50 60 MEKISRTKIV DLLKRRDFGA MVNVKGWVRT RRGSKQVNFI ALNDGSTINN VQIVVDLANF 70 80 90 100 110 120 DEEMLKQITT GACISVNGEL TESIGSGQAA EVQARGIEVL GTCDNTYPLQ KKGHTMEFLR 130 140 150 160 170 180 EIAHLRPRTN TFGAVFRIRH NMAIAIHKFF HERGFFYFHT PIITASDCEG AGQMFQVTTK 190 200 210 220 230 240 NLYDLKKDEN GAIIYDDDFF GKQASLTVSG QLEGELAATA LGAIYTFGPT FRAENSNTPR 250 260 270 280 290 300 HLAEFWMIEP EVAFNDITDN MDLAEDFIKY CVQWALDNCY DDVKFLNDMF DKGLIERLQG 310 320 330 340 350 360 VLKEEFVRLP YTEGIKILEE AVVKGHKFEF PVYWGVDLAS EHERYLVEEH FKRPVILTDY 370 380 390 400 410 420 PKEIKAFYMK QNEDGKTVRA MDVLFPKIGE IIGGSEREAD YDKLMTRIQE LGIPMKDMWW 430 440 450 460 YLDTRKFGSC PHSGFGLGFE RLLLFVTGMT NIRDVIPFPR TPRNAEF

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000139 Genomic DNA. Translation: ABR39309.1.
RefSeq	YP_001298931.1. NC_009614.1.
3D structure databases
ProteinModelPortal	A6L0U5.
ModBase	Search...
Protein-protein interaction databases
STRING	A6L0U5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5302594.
GenomeReviews	Gene locus BVU_1628 in contig CP000139_GR.
KEGG	bvu:BVU_1628.
NMPDR	fig|435590.6.peg.1532.
PATRIC	21068134. VBIBacVul85104_1692.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0017.
HOGENOM	HBG745843.
OMA	AIHRFFH.
ProtClustDB	PRK03932.
Family and domain databases
HAMAP	MF_00534. Asn_tRNA_synth. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II. IPR004522. Asn-tRNA-synth_IIb. IPR002312. Asp/Asn-tRNA-synth_IIb. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR004365. NA-bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KO	K01893.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF6. PTHR22594:SF6. 1 hit.
Pfam	PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00457. AsnS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYN_BACV8

Accession

Primary (citable) accession number: A6L0U5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program