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A6L073 (A6L073_BACV8) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639 RuleBase RU003664
EC=6.3.2.9 HAMAP MF_00639 RuleBase RU003664
Alternative name(s):
D-glutamic acid-adding enzyme HAMAP MF_00639
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase HAMAP MF_00639
Gene names
Name:murD HAMAP MF_00639
Ordered Locus Names:BVU_1399
OrganismBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]
Taxonomic identifier435590 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Subcellular location

Cytoplasm By similarity HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762.

Sequence similarities

Belongs to the MurCDEF family. HAMAP MF_00639 RuleBase RU003630

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding110 – 1167ATP By similarity HAMAP MF_00639

Sequences

Sequence LengthMass (Da)Tools
A6L073 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 027F0B66DF6677D3

FASTA44449,955
        10         20         30         40         50         60 
MAKRIVILGA GESGAGAAVL AKKQGFDTFV SDMSTIKDIY KNMLNERGIE WEEGKHTESL 

        70         80         90        100        110        120 
ILNADEVIKS PGIPNDAPMI LKLKSQGTPI ISEIEFAGRY TNAKMICITG SNGKTTTTSL 

       130        140        150        160        170        180 
IYHIFKKAGM NVGLAGNIGQ SLAYQVAECN YDYYVIELSS FQLDNMYKFH ANIAVLMNIT 

       190        200        210        220        230        240 
PDHLDRYDHQ MQNYVDAKFR IIQNQTPDDA FIFWNDDPII QRELHKYGIH GHYYPFAERK 

       250        260        270        280        290        300 
EEGTAAYVEQ DKVYFTEPIA FNMEQEELAL TGTHNLFNSM AAGISANLAG IRKECIREAL 

       310        320        330        340        350        360 
GDFKGVEHRL EKVCRVRGVD YINDSKATNV NSCWYALQSM KTKTILILGG KDKGNDYNEI 

       370        380        390        400        410        420 
ADLVKEKCTG LIYMGLHNEK LHDFFDKFGL PVADVQSMKD AVDAAYRMAK KGETVLLSPC 

       430        440 
CASFDLFKSY EDRGEQFKEC VRNL

« Hide

References

[1]"Evolution of symbiotic bacteria in the distal human intestine."
Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I.
PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000139 Genomic DNA. Translation: ABR39087.1.
RefSeqYP_001298709.1. NC_009614.1.

3D structure databases

ProteinModelPortalA6L073.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6L073.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5302365.
GenomeReviewsGene locus BVU_1399 in contig CP000139_GR.
KEGGbvu:BVU_1399.
NMPDRfig|435590.6.peg.1321.
PATRIC21067656. VBIBacVul85104_1460.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0771.
HOGENOMHBG750024.
OMAACASWDM.
ProtClustDBCLSK2757457.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01925.
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. MurD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA6L073_BACV8
AccessionPrimary (citable) accession number: A6L073
Entry history
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info