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A6L048 (FUCI_BACV8) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-fucose isomerase

EC=5.3.1.25
Alternative name(s):
6-deoxy-L-galactose isomerase
FucIase
Gene names
Name:fucI
Ordered Locus Names:BVU_1373
OrganismBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]
Taxonomic identifier435590 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length591 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts the aldose L-fucose into the corresponding ketose L-fuculose By similarity. HAMAP-Rule MF_01254

Catalytic activity

L-fucopyranose = L-fuculose. HAMAP-Rule MF_01254

Cofactor

Manganese By similarity. HAMAP-Rule MF_01254

Pathway

Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3. HAMAP-Rule MF_01254

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01254.

Sequence similarities

Belongs to the L-fucose isomerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Fucose metabolism
   Cellular componentCytoplasm
   LigandManganese
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processL-fucose catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-fucose isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

manganese ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 591591L-fucose isomerase HAMAP-Rule MF_01254
PRO_1000067214

Sites

Active site3381Proton acceptor By similarity
Active site3621Proton acceptor By similarity
Metal binding3381Manganese By similarity
Metal binding3621Manganese By similarity
Metal binding5291Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
A6L048 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 4FDDE43BE6329449

FASTA59165,620
        10         20         30         40         50         60 
MKKYPKIGIR PTIDGRQGGV RESLEDKTMN LAKAVAELIS SNLKNGDGSP VECVIADSTI 

        70         80         90        100        110        120 
GRVAESAACA EKFEREGVGA TITVTSCWCY GSETMDMHPH WPKAVWGFNG TERPGAVYLA 

       130        140        150        160        170        180 
AVLAGHAQKG LPAFGIYGHD VQDLDDNTIP ADVAEKLLRF ARAAMAVANM RGKSYLSFGS 

       190        200        210        220        230        240 
VCMGIAGSIV DPDFFQEYLG IRNESVDETE ILRRMEEGIY DHEEYAKAMA WTEKYCKPNE 

       250        260        270        280        290        300 
GEDFKNRPEK RKTREEKDAD WEFIVKMTII MRDLMVGNPK LLEMGFKEEA IGHNAIAAGF 

       310        320        330        340        350        360 
QGQRQWTDWK PNGDFSEALL NTTFDWNGIR EAYVLATEND ACNGVAMLFG HLLSGCGQMF 

       370        380        390        400        410        420 
SDIRTYWSPE AVKRVTGKEL TGMAKNGIIH LINSGATTLD ATGESHNEAG EPCMKPNWEM 

       430        440        450        460        470        480 
TEADVEACLK ATTWYPADRD YFRGGGFSSN FLSKGGMPVT MMRLNLVKGL GPVLQLAEGW 

       490        500        510        520        530        540 
TVDIDPEIHQ VLNMRTDPTW PTTWFVPRLC DKPAFRDVYS VMNNWGANHG AISYGHIGQD 

       550        560        570        580        590 
LITLASMLRI PVCMHNVEDD KIFRPASWNA FGMDKEGSDY RACSTYGPIY K 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000139 Genomic DNA. Translation: ABR39062.1.
RefSeqYP_001298684.1. NC_009614.1.

3D structure databases

ProteinModelPortalA6L048.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING435590.BVU_1373.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR39062; ABR39062; BVU_1373.
GeneID5302339.
KEGGbvu:BVU_1373.
PATRIC21067594. VBIBacVul85104_1430.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2407.
HOGENOMHOG000249674.
KOK01818.
OMAKIGIRPT.
OrthoDBEOG6FJNCF.
ProtClustDBPRK10991.

Enzyme and pathway databases

BioCycBVUL435590:GH96-1370-MONOMER.
UniPathwayUPA00563; UER00624.

Family and domain databases

Gene3D3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPMF_01254. Fucose_iso.
InterProIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsTIGR01089. fucI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFUCI_BACV8
AccessionPrimary (citable) accession number: A6L048
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways