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Protein

L-fucose isomerase

Gene

fucI

Organism
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei338Proton acceptorUniRule annotation1
Metal bindingi338ManganeseUniRule annotation1
Active sitei362Proton acceptorUniRule annotation1
Metal bindingi362ManganeseUniRule annotation1
Metal bindingi529ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:BVU_1373
OrganismiBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)
Taxonomic identifieri435590 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000002861 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000672141 – 591L-fucose isomeraseAdd BLAST591

Interactioni

Protein-protein interaction databases

STRINGi435590.BVU_1373.

Structurei

3D structure databases

ProteinModelPortaliA6L048.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EHF. Bacteria.
COG2407. LUCA.
HOGENOMiHOG000249674.
KOiK01818.
OMAiGAISYGH.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso. 1 hit.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

A6L048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKYPKIGIR PTIDGRQGGV RESLEDKTMN LAKAVAELIS SNLKNGDGSP
60 70 80 90 100
VECVIADSTI GRVAESAACA EKFEREGVGA TITVTSCWCY GSETMDMHPH
110 120 130 140 150
WPKAVWGFNG TERPGAVYLA AVLAGHAQKG LPAFGIYGHD VQDLDDNTIP
160 170 180 190 200
ADVAEKLLRF ARAAMAVANM RGKSYLSFGS VCMGIAGSIV DPDFFQEYLG
210 220 230 240 250
IRNESVDETE ILRRMEEGIY DHEEYAKAMA WTEKYCKPNE GEDFKNRPEK
260 270 280 290 300
RKTREEKDAD WEFIVKMTII MRDLMVGNPK LLEMGFKEEA IGHNAIAAGF
310 320 330 340 350
QGQRQWTDWK PNGDFSEALL NTTFDWNGIR EAYVLATEND ACNGVAMLFG
360 370 380 390 400
HLLSGCGQMF SDIRTYWSPE AVKRVTGKEL TGMAKNGIIH LINSGATTLD
410 420 430 440 450
ATGESHNEAG EPCMKPNWEM TEADVEACLK ATTWYPADRD YFRGGGFSSN
460 470 480 490 500
FLSKGGMPVT MMRLNLVKGL GPVLQLAEGW TVDIDPEIHQ VLNMRTDPTW
510 520 530 540 550
PTTWFVPRLC DKPAFRDVYS VMNNWGANHG AISYGHIGQD LITLASMLRI
560 570 580 590
PVCMHNVEDD KIFRPASWNA FGMDKEGSDY RACSTYGPIY K
Length:591
Mass (Da):65,620
Last modified:July 24, 2007 - v1
Checksum:i4FDDE43BE6329449
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000139 Genomic DNA. Translation: ABR39062.1.
RefSeqiWP_005849650.1. NC_009614.1.

Genome annotation databases

EnsemblBacteriaiABR39062; ABR39062; BVU_1373.
GeneIDi5302339.
KEGGibvu:BVU_1373.
PATRICi21067594. VBIBacVul85104_1430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000139 Genomic DNA. Translation: ABR39062.1.
RefSeqiWP_005849650.1. NC_009614.1.

3D structure databases

ProteinModelPortaliA6L048.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi435590.BVU_1373.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR39062; ABR39062; BVU_1373.
GeneIDi5302339.
KEGGibvu:BVU_1373.
PATRICi21067594. VBIBacVul85104_1430.

Phylogenomic databases

eggNOGiENOG4105EHF. Bacteria.
COG2407. LUCA.
HOGENOMiHOG000249674.
KOiK01818.
OMAiGAISYGH.

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso. 1 hit.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFUCI_BACV8
AccessioniPrimary (citable) accession number: A6L048
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.