Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-fucose isomerase

Gene

fucI

Organism
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei338Proton acceptorUniRule annotation1
Metal bindingi338ManganeseUniRule annotation1
Active sitei362Proton acceptorUniRule annotation1
Metal bindingi362ManganeseUniRule annotation1
Metal bindingi529ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Fucose metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:BVU_1373
OrganismiBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)
Taxonomic identifieri435590 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000002861 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000672141 – 591L-fucose isomeraseAdd BLAST591

Proteomic databases

PRIDEiA6L048

Interactioni

Protein-protein interaction databases

STRINGi435590.BVU_1373

Structurei

3D structure databases

ProteinModelPortaliA6L048
SMRiA6L048
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EHF Bacteria
COG2407 LUCA
HOGENOMiHOG000249674
KOiK01818
OMAiHAQKGLP

Family and domain databases

Gene3Di3.20.14.10, 1 hit
3.40.275.10, 1 hit
3.40.50.1070, 1 hit
HAMAPiMF_01254 Fucose_iso, 1 hit
InterProiView protein in InterPro
IPR004216 Fuc/Ara_isomerase_C
IPR038393 Fuc_iso_dom3_sf
IPR015888 Fuc_isomerase_C
IPR038391 Fucose_iso_dom1_sf
IPR012888 Fucose_iso_N1
IPR005763 Fucose_isomerase
IPR038392 Fucose_isomerase_dom2_sf
IPR009015 Fucose_isomerase_N/cen_sf
IPR012889 Fucose_isomerase_N2
PfamiView protein in Pfam
PF02952 Fucose_iso_C, 1 hit
PF07881 Fucose_iso_N1, 1 hit
PF07882 Fucose_iso_N2, 1 hit
SUPFAMiSSF50443 SSF50443, 1 hit
SSF53743 SSF53743, 1 hit
TIGRFAMsiTIGR01089 fucI, 1 hit

Sequencei

Sequence statusi: Complete.

A6L048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKYPKIGIR PTIDGRQGGV RESLEDKTMN LAKAVAELIS SNLKNGDGSP
60 70 80 90 100
VECVIADSTI GRVAESAACA EKFEREGVGA TITVTSCWCY GSETMDMHPH
110 120 130 140 150
WPKAVWGFNG TERPGAVYLA AVLAGHAQKG LPAFGIYGHD VQDLDDNTIP
160 170 180 190 200
ADVAEKLLRF ARAAMAVANM RGKSYLSFGS VCMGIAGSIV DPDFFQEYLG
210 220 230 240 250
IRNESVDETE ILRRMEEGIY DHEEYAKAMA WTEKYCKPNE GEDFKNRPEK
260 270 280 290 300
RKTREEKDAD WEFIVKMTII MRDLMVGNPK LLEMGFKEEA IGHNAIAAGF
310 320 330 340 350
QGQRQWTDWK PNGDFSEALL NTTFDWNGIR EAYVLATEND ACNGVAMLFG
360 370 380 390 400
HLLSGCGQMF SDIRTYWSPE AVKRVTGKEL TGMAKNGIIH LINSGATTLD
410 420 430 440 450
ATGESHNEAG EPCMKPNWEM TEADVEACLK ATTWYPADRD YFRGGGFSSN
460 470 480 490 500
FLSKGGMPVT MMRLNLVKGL GPVLQLAEGW TVDIDPEIHQ VLNMRTDPTW
510 520 530 540 550
PTTWFVPRLC DKPAFRDVYS VMNNWGANHG AISYGHIGQD LITLASMLRI
560 570 580 590
PVCMHNVEDD KIFRPASWNA FGMDKEGSDY RACSTYGPIY K
Length:591
Mass (Da):65,620
Last modified:July 24, 2007 - v1
Checksum:i4FDDE43BE6329449
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000139 Genomic DNA Translation: ABR39062.1
RefSeqiWP_005849650.1, NC_009614.1

Genome annotation databases

EnsemblBacteriaiABR39062; ABR39062; BVU_1373
GeneIDi5302339
KEGGibvu:BVU_1373

Similar proteinsi

Entry informationi

Entry nameiFUCI_BACV8
AccessioniPrimary (citable) accession number: A6L048
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health