A6L012 (SPEA_BACV8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Biosynthetic arginine decarboxylase
Short name=ADC
EC=4.1.1.19

Gene names

Name:	speA
Ordered Locus Names:	BVU_1337

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	630 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP MF_01417
Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01417
Cofactor	Magnesium By similarity. HAMAP MF_01417 Pyridoxal phosphate By similarity. HAMAP MF_01417
Pathway	Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP MF_01417
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Spermidine biosynthesis
Ligand	Magnesium Metal-binding Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro spermidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 630	630	Biosynthetic arginine decarboxylase HAMAP MF_01417		PRO_1000024256
Regions
	Region	281 – 291	11	Substrate-binding Potential
Amino acid modifications
	Modified residue	99	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6L012 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 9396373E70A8C266	FASTA	630	71,488
	10 20 30 40 50 60 MRKWRIEDSE ELYNITGWGT SYFGINDKGH VVVTPRKDGV EVDLKELVDE LQLRDVAAPM 70 80 90 100 110 120 LVRFPDILDN RIEKIANCFK QASDEYGYKA QNFIIYPIKV NQMRPVVEEI ISHGKKFNLG 130 140 150 160 170 180 LEAGSKPELH AVIAVNTDSD SLIICNGYKD ESYIELALLA QKMGKRIFLV VEKMNELRLI 190 200 210 220 230 240 AKMAKQLNVR PNIGIRIKLA SSGSGKWEDS GGDASKFGLT SSELLEALDF LEKKDMKDCL 250 260 270 280 290 300 KLIHFHIGSQ VTKIRRIKTA LREASQFYVQ LHVMGFNVEF VDIGGGLGVD YDGTRSANSE 310 320 330 340 350 360 SSVNYSIQEY VNDSISTLVD ASDKNGIPHP NIITESGRSL TAHHSVLIFE VLETATLPEM 370 380 390 400 410 420 DEDFEVGEND HELVHELYEI WDNLNQSRMV EAWHDAQQIR EEALDLFSHG IVDLKTRAQI 430 440 450 460 470 480 ERLYWSVTRE INQIASGLKH APDEFRKLDK LLADKYFCNF SLFQSLPDSW AIDQIFPIMP 490 500 510 520 530 540 IQRLDEKPDR NATLQDITCD SDGKIANFIS TRYVSHDLPV HSLKGKDAYY IGVFLVGAYQ 550 560 570 580 590 600 EILGDMHNLF GDTNAVHVTV DDKGYSIDQV IDGETVAEVL DYVQYNPKKL VRTLETWVTK 610 620 630 SVKEGRISVE EGKEFLSNYR SGLYGYTYLE

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000139 Genomic DNA. Translation: ABR39026.1.
RefSeq	YP_001298648.1. NC_009614.1.
3D structure databases
ProteinModelPortal	A6L012.
ModBase	Search...
Protein-protein interaction databases
STRING	A6L012.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5302303.
GenomeReviews	Gene locus BVU_1337 in contig CP000139_GR.
KEGG	bvu:BVU_1337.
NMPDR	fig|435590.6.peg.1259.
PATRIC	21067514. VBIBacVul85104_1390.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1166.
HOGENOM	HBG321436.
OMA	LICNGYK.
ProtClustDB	PRK05354.
Family and domain databases
HAMAP	MF_01417. SpeA. [Tree]
InterPro	IPR009006. Ala_racemase/Decarboxylase_C. IPR002985. Arg_decrbxlase. IPR022643. De-COase2_C. IPR022657. De-COase2_CS. IPR022644. De-COase2_N. IPR022653. De-COase2_pyr-phos_BS. IPR000183. Orn/DAP/Arg_de-COase. [Graphical view]
KO	K01585.
PANTHER	PTHR11482:SF3. Arg_decrbxlase. 1 hit.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PIRSF	PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTS	PR01180. ARGDCRBXLASE. PR01179. ODADCRBXLASE.
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR01273. SpeA. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEA_BACV8

Accession

Primary (citable) accession number: A6L012

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program