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A6KZJ8

- UPPP_BACV8

UniProt

A6KZJ8 - UPPP_BACV8

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBVUL435590:GH96-1168-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:BVU_1171
OrganismiBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
Taxonomic identifieri435590 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000002861: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121HelicalUniRule annotationAdd
BLAST
Transmembranei80 – 10021HelicalUniRule annotationAdd
BLAST
Transmembranei107 – 12721HelicalUniRule annotationAdd
BLAST
Transmembranei140 – 16021HelicalUniRule annotationAdd
BLAST
Transmembranei180 – 20021HelicalUniRule annotationAdd
BLAST
Transmembranei214 – 23421HelicalUniRule annotationAdd
BLAST
Transmembranei246 – 26621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Undecaprenyl-diphosphatasePRO_0000303019Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi435590.BVU_1171.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6KZJ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEWFEALILG VLQGLTEYLP VSSSGHLAIG SALFGIQGED NLTFTIAVHV
60 70 80 90 100
ATVLSTLVIL WKEIGWIFRG LFKFEMNAET KYVINILVSM IPIGIVGVFF
110 120 130 140 150
KDYVEEIFGS GLLIVGCMLL LTALLLAFSY YAKPRLKENI SMKDAFIIGL
160 170 180 190 200
AQACAVMPGL SRSGTTIATG LLLGDNKAKL AQFSFLMVIP PILGEALLDG
210 220 230 240 250
MKIVKGAAAG TSDISVLSLV VGFLAAFISG CVACKWMINI VKKGKLIYFA
260
IYCAIAGAVT IACTLM
Length:266
Mass (Da):28,478
Last modified:July 24, 2007 - v1
Checksum:iAA80432915A7BD82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000139 Genomic DNA. Translation: ABR38862.1.
RefSeqiYP_001298484.1. NC_009614.1.

Genome annotation databases

EnsemblBacteriaiABR38862; ABR38862; BVU_1171.
GeneIDi5302137.
KEGGibvu:BVU_1171.
PATRICi21067168. VBIBacVul85104_1219.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000139 Genomic DNA. Translation: ABR38862.1 .
RefSeqi YP_001298484.1. NC_009614.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 435590.BVU_1171.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR38862 ; ABR38862 ; BVU_1171 .
GeneIDi 5302137.
KEGGi bvu:BVU_1171.
PATRICi 21067168. VBIBacVul85104_1219.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BVUL435590:GH96-1168-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Entry informationi

Entry nameiUPPP_BACV8
AccessioniPrimary (citable) accession number: A6KZJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3