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A6KZH6 (SYL_BACV8) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:BVU_1149
OrganismBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]
Taxonomic identifier435590 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides

Protein attributes

Sequence length944 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 944944Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009294

Regions

Motif40 – 5112"HIGH" region HAMAP-Rule MF_00049
Motif718 – 7225"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site7211ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A6KZH6 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 90C19E42471E1C73

FASTA944108,274
        10         20         30         40         50         60 
MEYNFREIEK KWQQRWAENH TYQVTEDESK KKFYVLNMFP YPSGAGLHVG HPLGYIASDI 

        70         80         90        100        110        120 
YARYKRLQGF NVLNPMGYDA YGLPAEQYAI QTGQHPAITT VNNINRYREQ LDKIGFSFDW 

       130        140        150        160        170        180 
NREVRTCEPG YYHWTQWAFQ QMFNSYYCND TQQARPISEL TEAFARYGNE GLNAACSEEL 

       190        200        210        220        230        240 
SFTAEEWNAK SEKEQQEILM NYRIAYLGET MVNWCPQLGT VLANDEVVDG VSERGGFPVV 

       250        260        270        280        290        300 
QKKMRQWCLR VSAYAQRLLD GLDTVDWTDS LKETQRNWIG RSEGTEVQFK VKDSDIEFTI 

       310        320        330        340        350        360 
FTTRADTMFG VTFMVLAPES ELVPQLTTEA QKAEVEAYLD RTKKRTERER IADRRVTGVF 

       370        380        390        400        410        420 
SGSYAINPFT GEAVPVWISD YVLAGYGTGA IMAVPAHDSR DYAFAKHFNL PIVPLVEGCD 

       430        440        450        460        470        480 
VSEESFDAKE GIVCNSPRKD VTPYCDLSLN GLTIKEAIAA TKEYVKAHNL GRVKVNYRLR 

       490        500        510        520        530        540 
DAIFSRQRYW GEPFPVYYKN GMPYMIDSSK LPLELPEVAK FLPTETGEPP LGHATKWAWD 

       550        560        570        580        590        600 
VEKGEVVENN LIDNVTIFPL ELNTMPGFAG SSAYYLRYMD PHNAQALVSE KADHYWQNVD 

       610        620        630        640        650        660 
LYVGGTEHAT GHLIYSRFWN KFLHDLGVSI KEEPFQKLVN QGMIQGRSNF VYRIKDTNTF 

       670        680        690        700        710        720 
VSLNLKDQYE TTPLHVDVNI VSNDILDVEA FKAWRPEYND AEFILEDGKY ICGWAVEKMS 

       730        740        750        760        770        780 
KSMYNVVNPD MIVEKYGADT LRMYEMFLGP VEQSKPWDTN GIDGVHRFLK KLWNLFYSRT 

       790        800        810        820        830        840 
DEFLPVEGEP TKEELKAIHK LIKKVTGDIE TFSYNTSISA FMICVNELTS LKCRNKEVLS 

       850        860        870        880        890        900 
NLIILLAPFA PHYAEELWEA LGNTTSVCDA QWPAFNEDYL KEDTVKYTIS FNGKARFTMD 

       910        920        930        940 
FAADADNNTI QTTVMADEQA QKWIEGKTPK KVIIVPKKIV NIVL 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000139 Genomic DNA. Translation: ABR38840.1.
RefSeqYP_001298462.1. NC_009614.1.

3D structure databases

ProteinModelPortalA6KZH6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING435590.BVU_1149.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR38840; ABR38840; BVU_1149.
GeneID5302115.
KEGGbvu:BVU_1149.
PATRIC21067120. VBIBacVul85104_1195.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycBVUL435590:GH96-1146-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_BACV8
AccessionPrimary (citable) accession number: A6KZH6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries