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A6KZH6

- SYL_BACV8

UniProt

A6KZH6 - SYL_BACV8

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei721 – 7211ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBVUL435590:GH96-1146-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BVU_1149
    OrganismiBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
    Taxonomic identifieri435590 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000002861: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 944944Leucine--tRNA ligasePRO_1000009294Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi435590.BVU_1149.

    Structurei

    3D structure databases

    ProteinModelPortaliA6KZH6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi718 – 7225"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6KZH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYNFREIEK KWQQRWAENH TYQVTEDESK KKFYVLNMFP YPSGAGLHVG    50
    HPLGYIASDI YARYKRLQGF NVLNPMGYDA YGLPAEQYAI QTGQHPAITT 100
    VNNINRYREQ LDKIGFSFDW NREVRTCEPG YYHWTQWAFQ QMFNSYYCND 150
    TQQARPISEL TEAFARYGNE GLNAACSEEL SFTAEEWNAK SEKEQQEILM 200
    NYRIAYLGET MVNWCPQLGT VLANDEVVDG VSERGGFPVV QKKMRQWCLR 250
    VSAYAQRLLD GLDTVDWTDS LKETQRNWIG RSEGTEVQFK VKDSDIEFTI 300
    FTTRADTMFG VTFMVLAPES ELVPQLTTEA QKAEVEAYLD RTKKRTERER 350
    IADRRVTGVF SGSYAINPFT GEAVPVWISD YVLAGYGTGA IMAVPAHDSR 400
    DYAFAKHFNL PIVPLVEGCD VSEESFDAKE GIVCNSPRKD VTPYCDLSLN 450
    GLTIKEAIAA TKEYVKAHNL GRVKVNYRLR DAIFSRQRYW GEPFPVYYKN 500
    GMPYMIDSSK LPLELPEVAK FLPTETGEPP LGHATKWAWD VEKGEVVENN 550
    LIDNVTIFPL ELNTMPGFAG SSAYYLRYMD PHNAQALVSE KADHYWQNVD 600
    LYVGGTEHAT GHLIYSRFWN KFLHDLGVSI KEEPFQKLVN QGMIQGRSNF 650
    VYRIKDTNTF VSLNLKDQYE TTPLHVDVNI VSNDILDVEA FKAWRPEYND 700
    AEFILEDGKY ICGWAVEKMS KSMYNVVNPD MIVEKYGADT LRMYEMFLGP 750
    VEQSKPWDTN GIDGVHRFLK KLWNLFYSRT DEFLPVEGEP TKEELKAIHK 800
    LIKKVTGDIE TFSYNTSISA FMICVNELTS LKCRNKEVLS NLIILLAPFA 850
    PHYAEELWEA LGNTTSVCDA QWPAFNEDYL KEDTVKYTIS FNGKARFTMD 900
    FAADADNNTI QTTVMADEQA QKWIEGKTPK KVIIVPKKIV NIVL 944
    Length:944
    Mass (Da):108,274
    Last modified:July 24, 2007 - v1
    Checksum:i90C19E42471E1C73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000139 Genomic DNA. Translation: ABR38840.1.
    RefSeqiYP_001298462.1. NC_009614.1.

    Genome annotation databases

    EnsemblBacteriaiABR38840; ABR38840; BVU_1149.
    GeneIDi5302115.
    KEGGibvu:BVU_1149.
    PATRICi21067120. VBIBacVul85104_1195.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000139 Genomic DNA. Translation: ABR38840.1 .
    RefSeqi YP_001298462.1. NC_009614.1.

    3D structure databases

    ProteinModelPortali A6KZH6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 435590.BVU_1149.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR38840 ; ABR38840 ; BVU_1149 .
    GeneIDi 5302115.
    KEGGi bvu:BVU_1149.
    PATRICi 21067120. VBIBacVul85104_1195.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BVUL435590:GH96-1146-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

    Entry informationi

    Entry nameiSYL_BACV8
    AccessioniPrimary (citable) accession number: A6KZH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3