A6KYP1 (PYRE_BACV8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Orotate phosphoribosyltransferase
Short name=OPRT
Short name=OPRTase
EC=2.4.2.10

Gene names

Name:	pyrE
Ordered Locus Names:	BVU_0860

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208
Catalytic activity	Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208
Cofactor	Magnesium By similarity. HAMAP MF_01208
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208
Subunit structure	Homodimer By similarity. HAMAP MF_01208
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Magnesium
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	orotate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Orotate phosphoribosyltransferase HAMAP MF_01208		PRO_1000066205
Regions
	Region	123 – 131	9	5-phosphoribose 1-diphosphate binding By similarity
Sites
	Binding site	97	1	5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
	Binding site	101	1	5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
	Binding site	103	1	5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
	Binding site	127	1	Orotate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6KYP1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 581EC164D52E1749	FASTA	212	23,411
	10 20 30 40 50 60 MKTLEKLFAE KLLKIKAIKL QPANPFTWAS GWKSPFYCDN RKTLSYPSLR NFVKLEISRI 70 80 90 100 110 120 VLEKFGQVDA IAGVATGAIP QGALVAEELN LPFVYVRSTP KDHGLENLIE GELRPGMKVV 130 140 150 160 170 180 VIEDLISTGG SSLKAVEAIR RDGCEVIGMV AAFTYGFPVA IEAFKEAKVN LVTLTNYEAV 190 200 210 LDSALKTGYI NEEDVPVLDN WRKDPAHWEA GK

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000139 Genomic DNA. Translation: ABR38555.1.
RefSeq	YP_001298177.1. NC_009614.1.
3D structure databases
ProteinModelPortal	A6KYP1.
ModBase	Search...
Protein-protein interaction databases
STRING	A6KYP1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5301827.
GenomeReviews	Gene locus BVU_0860 in contig CP000139_GR.
KEGG	bvu:BVU_0860.
NMPDR	fig|435590.6.peg.817.
PATRIC	21066492. VBIBacVul85104_0883.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0461.
HOGENOM	HBG404341.
OMA	LPMTYVR.
ProtClustDB	PRK00455.
Family and domain databases
HAMAP	MF_01208. PyrE. [Tree]
InterPro	IPR004467. Or_phspho_trans_clade-1. IPR023031. Orotate_PribosylTferase. IPR000836. PRibTrfase. [Graphical view]
KO	K00762.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR00336. PyrE. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRE_BACV8

Accession

Primary (citable) accession number: A6KYP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program