A6KYJ7 (EFG_BACV8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor G
Short name=EF-G

Gene names

Name:	fusA
Ordered Locus Names:	BVU_0807

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	705 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity. HAMAP MF_00054_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00054_B.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 705	705	Elongation factor G HAMAP MF_00054_B		PRO_1000008803
Regions
	Nucleotide binding	16 – 23	8	GTP By similarity
	Nucleotide binding	84 – 88	5	GTP By similarity
	Nucleotide binding	138 – 141	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6KYJ7 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 30D96D1199DE545B	FASTA	705	77,456
	10 20 30 40 50 60 MAKHDLHLTR NIGIMAHIDA GKTTTSERIL FYTGLTHKIG EVHDGAATMD WMEQEQERGI 70 80 90 100 110 120 TITSAATTTR WKYAGNTYKI NLIDTPGHVD FTAEVERSLR VLDGAVAAYC AVGGVEPQSE 130 140 150 160 170 180 TVWRQADKYN VPRIGYVNKM DRSGADFFEV VRQMKDVLGA NACPVVIPIG AEESFKGVVD 190 200 210 220 230 240 LIKMKAILWH DETMGADYSV EEIPANLVDE ANEWREKMLE KVAEFDDALM EKFFDDPSTI 250 260 270 280 290 300 TEEEILRALR AGTLKMDIVP MFCGSSFKNK GVQTLLDYVC AFLPSPLDTP AIVGTNPTTG 310 320 330 340 350 360 AEEDRKPSED EKTSALAFKI ATDPYVGRLT FFRVYSGKVE AGSYIYNTRS GKKERVSRLF 370 380 390 400 410 420 QMHSNKQNPV EVIGAGDIGA GVGFKDIRTG DTLCDEDAPI VLESMEFPDP VIGIAVEPKT 430 440 450 460 470 480 QKDLDKLSNG LAKLAEEDPT FTVKTDEQSG QTIISGMGEL HLDIIIDRLK REFKVECNQG 490 500 510 520 530 540 KPQVNYKEAI TKTVELREVY KKQSGGRGKF ADIIVAIGPV DEDFTQGGLQ FIDEVKGGNV 550 560 570 580 590 600 PKEFIPSVQK GFQTAMKNGV LAGYPLDSLK VVLKDGSFHP VDSDQLSFEI CAIQAYKNAC 610 620 630 640 650 660 AKAGPVLTEP IMKLEVVTPE ENMGDVIGDL NKRRGQVEGM ESSRSGARIV KAKVPLAEMF 670 680 690 700 GYVTALRTIT SGRATSSMTY DHHAQVSSSI AKAVLEEVKG RVDLV

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000139 Genomic DNA. Translation: ABR38511.1.
RefSeq	YP_001298133.1. NC_009614.1.
3D structure databases
ProteinModelPortal	A6KYJ7.
ModBase	Search...
Protein-protein interaction databases
STRING	A6KYJ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5301774.
GenomeReviews	Gene locus BVU_0807 in contig CP000139_GR.
KEGG	bvu:BVU_0807.
NMPDR	fig|435590.6.peg.773.
PATRIC	21066384. VBIBacVul85104_0838.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0480.
HOGENOM	HBG737692.
OMA	MAFKEAS.
ProtClustDB	PRK12739.
Family and domain databases
HAMAP	MF_00054_B. EF-G_EF-2_B. [Tree]
InterPro	IPR009022. Elongation_fac_G/III/V. IPR000795. ProtSyn_GTP-bd. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR005225. Small_GTP-bd_dom. IPR004540. Transl_elong_EFG/EF2. IPR000640. Transl_elong_EFG/EF2_C. IPR005517. Transl_elong_EFG/EF2_IV. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. G3DSA:3.30.70.240. Transl_elong_EFG/EF2_C. 1 hit.
KO	K02355.
Pfam	PF00679. EFG_C. 1 hit. PF03764. EFG_IV. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SMART	SM00838. EFG_C. 1 hit. SM00889. EFG_IV. 1 hit. [Graphical view]
SUPFAM	SSF54980. EFG_III_V. 2 hits. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00484. EF-G. 1 hit. TIGR00231. Small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFG_BACV8

Accession

Primary (citable) accession number: A6KYJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program