Reviewed, UniProtKB/Swiss-Prot A6KXY5 (ARGC_BACV8)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	BVU_0591

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000010979
Sites
	Active site	132	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6KXY5-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 784E99BF26893858	FASTA	322	36,012
	10 20 30 40 50 60 MIKAGIIGGA GYTAGELIRL LINHPDVDIK FINSSSNAGN KITDVHEGLY GETDLVFTDE 70 80 90 100 110 120 LPLDEIDVLF FCTAHGDTKK FMDSHNVPED LKIIDLSMDY RIKSDDHDFI YGLPELNRRA 130 140 150 160 170 180 ICHSKHVANP GCFATCIQLG LLPLAKHLLL NEDIMVNAIT GSTGAGVKPG ATSHFSWRNN 190 200 210 220 230 240 NMSIYKPFSH QHVPEIKQSL KQLQNSFNAE IDFIPYRGDF PRGIFATLVV KCKVELEELV 250 260 270 280 290 300 KMYQDYYAED SFVHIVDKNI DLKQVVNTNK CLIHLEKHGD KLLVISCIDN LLKGASGQAV 310 320 HNMNLMFNLE ETVGLRLKPS AF

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000139 Genomic DNA. Translation: ABR38299.1.
RefSeq	YP_001297921.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6KXY5.
Genome annotation databases
GeneID	5301559.
GenomeReviews	Gene locus BVU_0591 in contig CP000139_GR.
KEGG	bvu:BVU_0591.
NMPDR	fig|435590.6.peg.566.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TSHFSWR.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BACV8

Accession

Primary (citable) accession number: A6KXY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)