Reviewed, UniProtKB/Swiss-Prot A6KX92 (HUTI_BACV8)

Names and origin

Protein names

Recommended name:
    Imidazolonepropionase
    EC=3.5.2.7
Alternative name(s):
    Imidazolone-5-propionate hydrolase

Gene names

Name:	hutI
Ordered Locus Names:	BVU_0336

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372
Cofactor	Binds 1 zinc or iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the hutI family.

Ontologies

Keywords
Biological process	Histidine metabolism
Cellular component	Cytoplasm
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine catabolic process to glutamate and formamide Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	imidazolonepropionase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	Imidazolonepropionase HAMAP MF_00372		PRO_0000306438
Sites
	Metal binding	77	1	Zinc or iron By similarity
	Metal binding	79	1	Zinc or iron By similarity
	Metal binding	249	1	Zinc or iron By similarity
	Metal binding	323	1	Zinc or iron By similarity
	Binding site	86	1	Substrate By similarity
	Binding site	99	1	Substrate By similarity
	Binding site	149	1	Substrate By similarity
	Binding site	184	1	Substrate By similarity
	Binding site	252	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6KX92-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 3E16F3366E2C6F93	FASTA	414	44,945
	10 20 30 40 50 60 MSNNLIIINA HIVTPQGRTA RKGEAMNELL NIPCGTVRVT DGIITYVGEN RISHEKPGYK 70 80 90 100 110 120 VLDARGNVLL PGFVDSHTHL VFGGFRPDEF IWRLNGDSYM SIMERGGGII NTVRATREAS 130 140 150 160 170 180 FEELKHKAEW FLDTMSRMGV TTVEGKSGYG LDRDTELKQL SIMQAINECP DRKVDIATTF 190 200 210 220 230 240 LGAHALPEEY KGRSDAYIDF LINEMLPMIH QKQLAENCDI FCEKGVFTVE QSRKLLKAAQ 250 260 270 280 290 300 ALGFGTKLHA DEIVSFGGAE LAGELKALSA DHLLQASDEG IKALAQNNVV ATLLPLTAFT 310 320 330 340 350 360 LKEPYARGRK MIDSGCAVAL ATDLNPGSCF SGSIPLTFAL ACIYMKLTVA EAITAITLNG 370 380 390 400 410 AAALGRADRI GSIEAGKQGD FVLLGTDNPH ILPYYTGMNA VKLTIKGGRI LHSN

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000139 Genomic DNA. Translation: ABR38056.1.
RefSeq	YP_001297678.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6KX92.
Genome annotation databases
GeneID	5301305.
GenomeReviews	Gene locus BVU_0336 in contig CP000139_GR.
KEGG	bvu:BVU_0336.
NMPDR	fig|435590.6.peg.324.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MNMACTL.
Family and domain databases
HAMAP	MF_00372. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR005920. HutI. [Graphical view]
Pfam	PF01979. Amidohydro_1. 2 hits. [Graphical view]
ProDom	PD001248. Amidohydro_like. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01224. hutI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HUTI_BACV8

Accession

Primary (citable) accession number: A6KX92

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	July 24, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)