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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathway:iUMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961Proton donorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciBVUL435590:GH96-95-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:BVU_0095
OrganismiBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
Taxonomic identifieri435590 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000002861 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Orotidine 5'-phosphate decarboxylasePRO_1000138946Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi435590.BVU_0095.

Structurei

3D structure databases

ProteinModelPortaliA6KWL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiCVAYKPN.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

Sequencei

Sequence statusi: Complete.

A6KWL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKQQLFENI QKKKSFLCVG LDTDIKKIPE HLLKEEDPIF AFNKAIIDAT
60 70 80 90 100
APYCIAYKPN LAFYESMGVK GWIAFEKTVS YIKENYPDQF IIADAKRGDI
110 120 130 140 150
GNTSAMYART FFEELDIDSV TVAPYMGEDS VTPFLSYEGK WVILLALTSN
160 170 180 190 200
KGSHDFQLTE DTNGERLFEK VLRKSQEWAN DENMMYVVGA TQGRAFEDIR
210 220 230 240 250
KIVPNHFLLV PGIGAQGGSL EEVCKYGMNS TCGLIVNSSR AIIYADKTEN
260 270
FATVAGQEAQ KVQAQMEKIM CQ
Length:272
Mass (Da):30,600
Last modified:July 24, 2007 - v1
Checksum:iC376240C83A23AE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000139 Genomic DNA. Translation: ABR37825.1.
RefSeqiWP_005843024.1. NC_009614.1.

Genome annotation databases

EnsemblBacteriaiABR37825; ABR37825; BVU_0095.
GeneIDi5301065.
KEGGibvu:BVU_0095.
PATRICi21064865. VBIBacVul85104_0099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000139 Genomic DNA. Translation: ABR37825.1.
RefSeqiWP_005843024.1. NC_009614.1.

3D structure databases

ProteinModelPortaliA6KWL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi435590.BVU_0095.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR37825; ABR37825; BVU_0095.
GeneIDi5301065.
KEGGibvu:BVU_0095.
PATRICi21064865. VBIBacVul85104_0099.

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiCVAYKPN.
OrthoDBiEOG6DZF33.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.
BioCyciBVUL435590:GH96-95-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Entry informationi

Entry nameiPYRF_BACV8
AccessioniPrimary (citable) accession number: A6KWL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 24, 2007
Last modified: July 22, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.