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Protein

Clavesin-1

Gene

Clvs1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • lysosome organization Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Clavesin-11 Publication
Alternative name(s):
Retinaldehyde-binding protein 1-like 1
Gene namesi
Name:Clvs11 Publication
Synonyms:Rlbp1l1By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1564200. Clvs1.

Subcellular locationi

GO - Cellular componenti

  • clathrin-coated vesicle Source: UniProtKB
  • early endosome membrane Source: UniProtKB-SubCell
  • endosome Source: UniProtKB
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003896191 – 354Clavesin-1Add BLAST354

Proteomic databases

PaxDbiA6JFQ6.
PeptideAtlasiA6JFQ6.
PRIDEiA6JFQ6.

Expressioni

Tissue specificityi

Expressed in brain with no expression detected in non-neuronal tissues (at protein level).1 Publication

Interactioni

Subunit structurei

Forms a complex with clathrin heavy chain and gamma-adaptin.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009744.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 279CRAL-TRIOPROSITE-ProRule annotationAdd BLAST162

Domaini

The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.By similarity

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
HOGENOMiHOG000059544.
InParanoidiA6JFQ6.
PhylomeDBiA6JFQ6.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR028634. Clavesin-1.
IPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PANTHERiPTHR10174:SF72. PTHR10174:SF72. 1 hit.
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6JFQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPVSVLPKP QSISTWEGDL AKMTHLQAGL SPDTIEKARL ELNENPDVLH
60 70 80 90 100
QDIQQVRDMI ITRPDIGFLR TDDAFILRFL RARKFHQADA FRLLAQYFQY
110 120 130 140 150
RQLNLDMFKN FKADDPGIKR ALIDGFPGVL ENRDHYGRKI LLLFAANWDQ
160 170 180 190 200
SRNSFTDILR AILLSLEVLI EDPELQINGF ILIIDWSNFS FKQASKLTPS
210 220 230 240 250
ILKLAIEGLQ DSFPARFGGV HFVNQPWYIH ALYTLIKPFL KDKTRKRIFL
260 270 280 290 300
HGNNLNSLHQ LIHPEFLPSE FGGTLPPYDM GTWARTLLGP DYSDENDYTH
310 320 330 340 350
TSYNAMYVKH TCSNLERECS PKPMKRSQSV VEAGTLKHEE KGENENTQPL

LALD
Length:354
Mass (Da):40,667
Last modified:December 15, 2009 - v1
Checksum:iC4A8C46E62368ACC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473984 Genomic DNA. Translation: EDM11652.1.
RefSeqiNP_001102439.1. NM_001108969.1.
UniGeneiRn.168299.

Genome annotation databases

GeneIDi366311.
KEGGirno:366311.
UCSCiRGD:1564200. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473984 Genomic DNA. Translation: EDM11652.1.
RefSeqiNP_001102439.1. NM_001108969.1.
UniGeneiRn.168299.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009744.

Proteomic databases

PaxDbiA6JFQ6.
PeptideAtlasiA6JFQ6.
PRIDEiA6JFQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi366311.
KEGGirno:366311.
UCSCiRGD:1564200. rat.

Organism-specific databases

CTDi157807.
RGDi1564200. Clvs1.

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
HOGENOMiHOG000059544.
InParanoidiA6JFQ6.
PhylomeDBiA6JFQ6.

Miscellaneous databases

PROiA6JFQ6.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR028634. Clavesin-1.
IPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PANTHERiPTHR10174:SF72. PTHR10174:SF72. 1 hit.
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLVS1_RAT
AccessioniPrimary (citable) accession number: A6JFQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: December 15, 2009
Last modified: October 5, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binding to PtdIns(3,5)P2 is not required for localization.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.