A6H8Y1 (BDP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor TFIIIB component B'' homolog

Alternative name(s):
Transcription factor IIIB 150
Short name=TFIIIB150
Transcription factor-like nuclear regulator

Gene names

Name:	BDP1
Synonyms:	KIAA1241, KIAA1689, TFNR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2624 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. Ref.1
Subunit structure	Component of TFIIIB complex. The TFIIIB complex has two activities, alpha and beta. The TFIIIB-alpha and TFIIIB-beta activities are required for transcription of genes with TFIIIC-bound internal promoters and PSE transcription factor-bound external promoters, respectively. The TFIIIB-alpha activity complex is composed of TBP, BDP1, and a complex containing both BRF2 and at least four stably associated proteins; YY1 facilitates the formation of TFIIIB-alpha activity complex. The TFIIIB-beta activity complex is composed of TBP, BDP1, and BRF1. Interacts with BRF1; this interaction diminishes during mitosis resulting in the release of BDP1 from chromosomal templates. Component of TFIIIC complex. The TFIIIC complex has two activities, C1 and C2. The TFIIIC2 activity complex is only required for transcription of the 'classical' pol III genes whereas the TFIIIC1 activity complex is required for transcription of all pol III genes. The TFIIIC1 activity complex is composed at least of BDP1. Interacts with ZBTB43. Ref.12 Ref.15 Ref.16
Subcellular location	Nucleus Ref.2.
Tissue specificity	Isoform 2 is highly expressed in cerebellum. Ref.2
Induction	By Epstein-Barr virus (EBV) resulting in the stimulation of the EBV EBER genes. Ref.17
Post-translational modification	Phosphorylated by CSNK2A1 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. Ref.14
Sequence similarities	Contains 1 Myb-like domain.
Sequence caution	The sequence AAG09268.1 differs from that shown. Reason: Frameshift at positions 837 and 863. The sequence AAH32146.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAA86555.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB21780.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAH18085.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription from RNA polymerase III promoter Traceable author statement. Source: Reactome
Cellular_component	nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro chromatin binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6H8Y1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A6H8Y1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2249-2254: YTPTSI → VKECTV
     2255-2624: Missing.

Isoform 3 (identifier: A6H8Y1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1354-1388: NISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISS → VCIFLSFKSFLNAFSEEINNSMIILSLSPTTLKNL
     1389-2624: Missing.

Isoform 4 (identifier: A6H8Y1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1354-1372: NISSEVLSMMHTPVEEKRN → VCIFLSFKSFLNAFFRGNK
     1373-2624: Missing.

Isoform 5 (identifier: A6H8Y1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-610: Missing.
     1354-1388: NISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISS → VCIFLSFKSFLNAFSEEINNSMIILSLSPTTFKNL
     1389-2624: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: A6H8Y1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     24-43: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: A6H8Y1-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1977-2008: Missing.
     2582-2584: VSC → RPF
     2585-2624: Missing.

Note: No experimental confirmation available.

Isoform 8 (identifier: A6H8Y1-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1863: Missing.
     2008-2008: Missing.
     2271-2327: NLVANVPQDG...ILVKSVNTEE → FVYQQLQLVK...FLLPKNVHSL
     2328-2624: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2624	2624	Transcription factor TFIIIB component B'' homolog		PRO_0000333863
Regions
	Domain	295 – 345	51	Myb-like
	Repeat	823 – 877	55	1; approximate
	Repeat	878 – 932	55	2
	Repeat	933 – 987	55	3
	Repeat	988 – 1040	53	4
	Repeat	1041 – 1094	54	5
	Repeat	1095 – 1148	54	6
	Repeat	1149 – 1203	55	7
	Repeat	1204 – 1257	54	8; approximate
	Repeat	1258 – 1327	70	9; approximate
	Region	1 – 299	299	Interaction with ZBTB43
	Region	355 – 470	116	Required for phosphorylation by CSNK2A1
	Region	823 – 1327	505	9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N-G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R-E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X-D-L-E-E-T
	Coiled coil	144 – 177	34	Potential
	Coiled coil	1078 – 1103	26	Potential
	Coiled coil	1223 – 1284	62	Potential
	Compositional bias	84 – 119	36	Ser-rich
Amino acid modifications
	Modified residue	915	1	Phosphothreonine Ref.18
Natural variations
	Alternative sequence	1 – 1863	1863	Missing in isoform 8.		VSP_033567
	Alternative sequence	1 – 610	610	Missing in isoform 5.		VSP_033568
	Alternative sequence	24 – 43	20	Missing in isoform 6.		VSP_033569
	Alternative sequence	1354 – 1388	35	NISSE…FKISS → VCIFLSFKSFLNAFSEEINN SMIILSLSPTTLKNL in isoform 3.		VSP_033570
	Alternative sequence	1354 – 1388	35	NISSE…FKISS → VCIFLSFKSFLNAFSEEINN SMIILSLSPTTFKNL in isoform 5.		VSP_033571
	Alternative sequence	1354 – 1372	19	NISSE…EEKRN → VCIFLSFKSFLNAFFRGNK in isoform 4.		VSP_033572
	Alternative sequence	1373 – 2624	1252	Missing in isoform 4.		VSP_033573
	Alternative sequence	1389 – 2624	1236	Missing in isoform 3 and isoform 5.		VSP_033574
	Alternative sequence	1977 – 2008	32	Missing in isoform 7.		VSP_033575
	Alternative sequence	2008	1	Missing in isoform 8.		VSP_033576
	Alternative sequence	2249 – 2254	6	YTPTSI → VKECTV in isoform 2.		VSP_033577
	Alternative sequence	2255 – 2624	370	Missing in isoform 2.		VSP_033578
	Alternative sequence	2271 – 2327	57	NLVAN…VNTEE → FVYQQLQLVKMPWVYLFLEE IILKSRLIIWILYLGRDFNA GLIKMTTFLLPKNVHSL in isoform 8.		VSP_033579
	Alternative sequence	2328 – 2624	297	Missing in isoform 8.		VSP_033580
	Alternative sequence	2582 – 2584	3	VSC → RPF in isoform 7.		VSP_033581
	Alternative sequence	2585 – 2624	40	Missing in isoform 7.		VSP_033582
	Natural variant	26	1	N → S. Corresponds to variant rs3748042 [ dbSNP | Ensembl ].		VAR_056743
	Natural variant	38	1	D → E. Ref.1 Ref.2 Ref.4 Ref.8 Corresponds to variant rs3748043 [ dbSNP | Ensembl ].		VAR_043312
	Natural variant	125	1	A → V. Corresponds to variant rs9687593 [ dbSNP | Ensembl ].		VAR_056744
	Natural variant	722	1	K → E. Corresponds to variant rs36009281 [ dbSNP | Ensembl ].		VAR_056745
	Natural variant	757	1	R → C. Ref.3 Ref.4 Ref.8 Corresponds to variant rs3761966 [ dbSNP | Ensembl ].		VAR_043313
	Natural variant	778	1	V → M. Corresponds to variant rs3761967 [ dbSNP | Ensembl ].		VAR_043314
	Natural variant	1180	1	G → S. Corresponds to variant rs715748 [ dbSNP | Ensembl ].		VAR_056746
	Natural variant	1244	1	F → I. Ref.4 Ref.8 Corresponds to variant rs1961760 [ dbSNP | Ensembl ].		VAR_056747
	Natural variant	1264	1	I → M. Ref.3 Ref.4 Ref.8 Corresponds to variant rs715747 [ dbSNP | Ensembl ].		VAR_043315
	Natural variant	1347	1	V → M. Ref.1 Ref.2 Ref.3 Ref.4 Ref.8 Corresponds to variant rs6886336 [ dbSNP | Ensembl ].		VAR_043316
	Natural variant	1469	1	K → E. Ref.4 Ref.8 Corresponds to variant rs1698063 [ dbSNP | Ensembl ].		VAR_043317
	Natural variant	1676	1	Q → E. Corresponds to variant rs12187098 [ dbSNP | Ensembl ].		VAR_056748
	Natural variant	2013	1	I → L. Ref.2 Ref.6 Corresponds to variant rs6453014 [ dbSNP | Ensembl ].		VAR_043318
	Natural variant	2555	1	N → S. Corresponds to variant rs17276250 [ dbSNP | Ensembl ].		VAR_056749
Experimental info
	Mutagenesis	390	1	S → A: Not phosphorylated by CSNK2A1; when associated with A-426; A-431; A-437 and A-446. CK2 treatment constitutively activates for U6 transcription; when associated with A-426; A-431; A-437 and A-446. Ref.14
	Mutagenesis	426	1	S → A: Not phosphorylated by CSNK2A1; when associated with A-390; A-431; A-437 and A-446. CK2 treatment constitutively activates for U6 transcription; when associated with A-390; A-431; A-437 and A-446. Ref.14
	Mutagenesis	431	1	S → A: Not phosphorylated by CSNK2A1; when associated with A-390; A-426; A-437 and A-446. CK2 treatment constitutively activates for U6 transcription; when associated with A-390; A-426; A-437 and A-446. Ref.14
	Mutagenesis	437	1	T → A: Not phosphorylated by CSNK2A1; when associated with A-390; A-426; A-431 and A-446. CK2 treatment constitutively activates for U6 transcription; when associated with A-390; A-426; A-431 and A-446. Ref.14
	Mutagenesis	446	1	S → A: Not phosphorylated by CSNK2A1; when associated with A-390; A-426; A-431 and A-437. CK2 treatment constitutively activates for U6 transcription; when associated with A-390; A-426; A-431 and A-437. Ref.14
	Sequence conflict	8	1	S → N in AAG09268. Ref.9
	Sequence conflict	233	1	E → G in AAG30221. Ref.1
	Sequence conflict	233	1	E → G in AAG30220. Ref.1
	Sequence conflict	575	1	R → K in BAB71602. Ref.10
	Sequence conflict	683	1	V → D in CAC21448. Ref.2
	Sequence conflict	881	1	A → T in AAG09268. Ref.9
	Sequence conflict	973	1	V → G in CAC21448. Ref.2
	Sequence conflict	973	1	V → G in CAC04245. Ref.2
	Sequence conflict	1009	1	E → G in AAG30221. Ref.1
	Sequence conflict	1009	1	E → G in AAG30220. Ref.1
	Sequence conflict	2580	1	T → A in CAE46010. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 3. Checksum: CB7B80EBBF06B557	FASTA	2,624	293,885
	10 20 30 40 50 60 MFRRARLSVK PNVRPGVGAR GSTASNPQRG RESPRPPDPA TDSASKPAEP TDVPTVDFGG 70 80 90 100 110 120 AEPQEKAPRS STEKTGGDND VEESSRSSST VSQRRKRISS TSSLVKSSVS VPSESHPLST 130 140 150 160 170 180 INQEAPQPTA TSTKEKQPCS DRYRIYKAQK LREMLKEELR KEKKQWKNKY AINESQRPPD 190 200 210 220 230 240 RSKMTMRDFI YYLPDNNPMT SSLEQEKKTE KPSTPVQTRE QEGKSTPNAE DNEMEEETDD 250 260 270 280 290 300 GPLLVPRVKV AEDGSIILDE ESLTVEVLRT KGPCVVEEND PIFERGSTTT YSSFRKNYYS 310 320 330 340 350 360 KPWSNKETDM FFLAISMVGT DFSMIGQLFP HRARIEIKNK FKREEKTNGW RIDKAFQEKR 370 380 390 400 410 420 PFDFDFFAHL LQKVLAEEEK RKQKSVKNHS LKEKKSTKPR KNVKVKKVAC EGVNNDPDES 430 440 450 460 470 480 MSSRISDTER SQKDAQTVEE ESLTLSREDA EQVALEVDLN QKKRRRKKQD GANELGVNNL 490 500 510 520 530 540 LENATVQAGP SKGEKHKNKC QAIRPELKEG ECSKEQMLSC TQNIDGIVGF ASTEKVEKRT 550 560 570 580 590 600 DPILSLSNQQ DATSVATESS ESSTSDLPSF EVGIRALCEV NNAEGSCIEE RNVDLKNNSL 610 620 630 640 650 660 EIDQTENVKP MLRGRFQRPK PNLSRAGKKS VLSQGKTESE SKNSHSKTSV EKNHVEKDKM 670 680 690 700 710 720 NTLDILRMET TERENPEAET VSVLGEKNCL QEGSQLKALR PVQVRGRLQK PKPNAGKAAE 730 740 750 760 770 780 RKEILISQEE IGANVEKNEN ESCADRDTPQ HMEDQSRKDF EEEDVILQPE KNDSFQNVQP 790 800 810 820 830 840 DEPKVLNECL SVQENNKANK LNQVPILRTR FQKPKPNIGR GTGRREISSK EEVLEKILVS 850 860 870 880 890 900 GEMAAALRET VRLDTSPKEM VPAEINTKEM QSDLKETGRR AISPREKILD VIDDTIEMET 910 920 930 940 950 960 GLKAMGREIC LREKTPEVID ATEEIDKDLE EAGRREISPQ KNGPEEVKPL GEVETDLKAT 970 980 990 1000 1010 1020 GNESSPREKT PEVTDATEEI DKNLEETGRR KISPRENGPE EVKPVDEMET DLNATGRESS 1030 1040 1050 1060 1070 1080 PREKTPEVID ATEEIDLEET EREVSPQENG LEEVKPLGEM ETDLKATGRD SFPRGKTPEV 1090 1100 1110 1120 1130 1140 IDAIEEIEID LEETEREISP QENGLEEVKP LGEMQTDLKA TGREISPREK TPEVIDATEE 1150 1160 1170 1180 1190 1200 IDKDLEETGR REISPEENGP EEVKPVDEME TDLKTTGREG SSREKTREVI DAAEVIETDL 1210 1220 1230 1240 1250 1260 EETEREISPQ ENGPEEVKPV GKMETDLKEI REEISQREKV LAEFSAIREK EIDLKETGKR 1270 1280 1290 1300 1310 1320 DIPIMEKVSG KMAVVEEMEA DLKETGKENF RERGSEEICV TEEKVAELKQ TGKTDISPRE 1330 1340 1350 1360 1370 1380 NELEETSTSR QTDTHLMQSG SNDFSAVPSL DIQNISSEVL SMMHTPVEEK RNSEKEVSSH 1390 1400 1410 1420 1430 1440 FSHFKISSQT HESDKTEVQG IQSPDVPEQF SDINLSKSLP QEQKPLEIKP APFVRSRFKR 1450 1460 1470 1480 1490 1500 PKPNLARAAL KRETTESEKY IYEKKSETKK METIVMQENN EQTDTLPSQH DEASLMISRE 1510 1520 1530 1540 1550 1560 KDTLGHRNEE AVILPCTQTE RNLSPSNSCE PKEESQSAPV QKNDSVVSVG TNNVNTFQQE 1570 1580 1590 1600 1610 1620 MKESVIQTAR QVRGRLQRPR PNIRKTGQRQ IVDKGEAKGI IKEGRTILPK DETEKKVLTV 1630 1640 1650 1660 1670 1680 SNSQIETEIE VPSSAVPEHR MYENQSQVVL VENLHVNKTN ETIRHENKPY VPSSAQMTRR 1690 1700 1710 1720 1730 1740 KFQKAKPNLG RAHSKKEEPV LEKVTTDQSK EGKPEDHLLQ KGASNTQLLL KEKAELLTSL 1750 1760 1770 1780 1790 1800 EVSARKDCVG SKESALAKID AELEEVGPSR RVGEETVGDN SPSSVVEEQY LNKLTSCPQP 1810 1820 1830 1840 1850 1860 LNETSYSKIA LDGKTTISST SEYERNRGER RSHKKFKPNV TRGRGSKRVR GKTSKKEPRA 1870 1880 1890 1900 1910 1920 SKAMLVTLRA SQEEDDDADD FESDYEEESY HLAPEEVNKA PVFVPVGLRS PEPVSAQIEE 1930 1940 1950 1960 1970 1980 TMEELEITVN VPDVGCIAVV EHELPNTDVT TEEMKQEENL SVPFEMTTSE HIQDEPGTND 1990 2000 2010 2020 2030 2040 GSTEAAITLL TMGDLVLQSE ISSEQGDVGV CIIPHVHSKD KSHIPSSLDN VNHKIVHECQ 2050 2060 2070 2080 2090 2100 ELSSPVITTS PASFEENKIV LEEQSSREEI SLMEKVKENA TPTRNTISKV TSNLRIRSRL 2110 2120 2130 2140 2150 2160 AKPKPNLEKT LGTNRLDDYQ EVSSLCVTKG AEMETQRETE KNASKATELE NKNLGPVTTA 2170 2180 2190 2200 2210 2220 ENKDQSKLAC VHGIKGTSIS SEVNLTERNE NQEESSQEVH MLSVAPVASS ETGPCTLGLD 2230 2240 2250 2260 2270 2280 RGLGENSVEE PQIKDSKGDS VLTLPVPEYT PTSIPEVQQE NIINPQDLTV NLVANVPQDG 2290 2300 2310 2320 2330 2340 EDEQAFILTL VEIPANAVEE FTDATAQFMP NPLLPAPILV KSVNTEERGD MSICLPATSV 2350 2360 2370 2380 2390 2400 GQDAMGLSIS GRDNSKKPPD NLDLVSRKRF QCRLDKNDHI PPAKKRSLTL RDDCQEYTTE 2410 2420 2430 2440 2450 2460 VHSKELTNVF EETGESHKGQ DIFLTSGSTL TTPEPQRQQV EAAFQSRGSR SPDACMDKNV 2470 2480 2490 2500 2510 2520 PQLPQDEMIV SDKEERTDAA PKSQQMDSRT SSSKASLSRP GRRPLGFLSL ICSKNSLESD 2530 2540 2550 2560 2570 2580 EPMQVHSKKR LKPLIPGLRK KLKRSNPFNE SQEKNRESSD LLPSPSVITT QSENISSSAT 2590 2600 2610 2620 QVSCDQPLLK EGYKSAQKRA PQGEATTVSE YFFNDIFIEV DETE
	Isoform 2 [UniParc]. Checksum: 5028C313143A257A	FASTA	2,254	252,841
	10 20 30 40 50 60 MFRRARLSVK PNVRPGVGAR GSTASNPQRG RESPRPPDPA TDSASKPAEP TDVPTVDFGG 70 80 90 100 110 120 AEPQEKAPRS STEKTGGDND VEESSRSSST VSQRRKRISS TSSLVKSSVS VPSESHPLST 130 140 150 160 170 180 INQEAPQPTA TSTKEKQPCS DRYRIYKAQK LREMLKEELR KEKKQWKNKY AINESQRPPD 190 200 210 220 230 240 RSKMTMRDFI YYLPDNNPMT SSLEQEKKTE KPSTPVQTRE QEGKSTPNAE DNEMEEETDD 250 260 270 280 290 300 GPLLVPRVKV AEDGSIILDE ESLTVEVLRT KGPCVVEEND PIFERGSTTT YSSFRKNYYS 310 320 330 340 350 360 KPWSNKETDM FFLAISMVGT DFSMIGQLFP HRARIEIKNK FKREEKTNGW RIDKAFQEKR 370 380 390 400 410 420 PFDFDFFAHL LQKVLAEEEK RKQKSVKNHS LKEKKSTKPR KNVKVKKVAC EGVNNDPDES 430 440 450 460 470 480 MSSRISDTER SQKDAQTVEE ESLTLSREDA EQVALEVDLN QKKRRRKKQD GANELGVNNL 490 500 510 520 530 540 LENATVQAGP SKGEKHKNKC QAIRPELKEG ECSKEQMLSC TQNIDGIVGF ASTEKVEKRT 550 560 570 580 590 600 DPILSLSNQQ DATSVATESS ESSTSDLPSF EVGIRALCEV NNAEGSCIEE RNVDLKNNSL 610 620 630 640 650 660 EIDQTENVKP MLRGRFQRPK PNLSRAGKKS VLSQGKTESE SKNSHSKTSV EKNHVEKDKM 670 680 690 700 710 720 NTLDILRMET TERENPEAET VSVLGEKNCL QEGSQLKALR PVQVRGRLQK PKPNAGKAAE 730 740 750 760 770 780 RKEILISQEE IGANVEKNEN ESCADRDTPQ HMEDQSRKDF EEEDVILQPE KNDSFQNVQP 790 800 810 820 830 840 DEPKVLNECL SVQENNKANK LNQVPILRTR FQKPKPNIGR GTGRREISSK EEVLEKILVS 850 860 870 880 890 900 GEMAAALRET VRLDTSPKEM VPAEINTKEM QSDLKETGRR AISPREKILD VIDDTIEMET 910 920 930 940 950 960 GLKAMGREIC LREKTPEVID ATEEIDKDLE EAGRREISPQ KNGPEEVKPL GEVETDLKAT 970 980 990 1000 1010 1020 GNESSPREKT PEVTDATEEI DKNLEETGRR KISPRENGPE EVKPVDEMET DLNATGRESS 1030 1040 1050 1060 1070 1080 PREKTPEVID ATEEIDLEET EREVSPQENG LEEVKPLGEM ETDLKATGRD SFPRGKTPEV 1090 1100 1110 1120 1130 1140 IDAIEEIEID LEETEREISP QENGLEEVKP LGEMQTDLKA TGREISPREK TPEVIDATEE 1150 1160 1170 1180 1190 1200 IDKDLEETGR REISPEENGP EEVKPVDEME TDLKTTGREG SSREKTREVI DAAEVIETDL 1210 1220 1230 1240 1250 1260 EETEREISPQ ENGPEEVKPV GKMETDLKEI REEISQREKV LAEFSAIREK EIDLKETGKR 1270 1280 1290 1300 1310 1320 DIPIMEKVSG KMAVVEEMEA DLKETGKENF RERGSEEICV TEEKVAELKQ TGKTDISPRE 1330 1340 1350 1360 1370 1380 NELEETSTSR QTDTHLMQSG SNDFSAVPSL DIQNISSEVL SMMHTPVEEK RNSEKEVSSH 1390 1400 1410 1420 1430 1440 FSHFKISSQT HESDKTEVQG IQSPDVPEQF SDINLSKSLP QEQKPLEIKP APFVRSRFKR 1450 1460 1470 1480 1490 1500 PKPNLARAAL KRETTESEKY IYEKKSETKK METIVMQENN EQTDTLPSQH DEASLMISRE 1510 1520 1530 1540 1550 1560 KDTLGHRNEE AVILPCTQTE RNLSPSNSCE PKEESQSAPV QKNDSVVSVG TNNVNTFQQE 1570 1580 1590 1600 1610 1620 MKESVIQTAR QVRGRLQRPR PNIRKTGQRQ IVDKGEAKGI IKEGRTILPK DETEKKVLTV 1630 1640 1650 1660 1670 1680 SNSQIETEIE VPSSAVPEHR MYENQSQVVL VENLHVNKTN ETIRHENKPY VPSSAQMTRR 1690 1700 1710 1720 1730 1740 KFQKAKPNLG RAHSKKEEPV LEKVTTDQSK EGKPEDHLLQ KGASNTQLLL KEKAELLTSL 1750 1760 1770 1780 1790 1800 EVSARKDCVG SKESALAKID AELEEVGPSR RVGEETVGDN SPSSVVEEQY LNKLTSCPQP 1810 1820 1830 1840 1850 1860 LNETSYSKIA LDGKTTISST SEYERNRGER RSHKKFKPNV TRGRGSKRVR GKTSKKEPRA 1870 1880 1890 1900 1910 1920 SKAMLVTLRA SQEEDDDADD FESDYEEESY HLAPEEVNKA PVFVPVGLRS PEPVSAQIEE 1930 1940 1950 1960 1970 1980 TMEELEITVN VPDVGCIAVV EHELPNTDVT TEEMKQEENL SVPFEMTTSE HIQDEPGTND 1990 2000 2010 2020 2030 2040 GSTEAAITLL TMGDLVLQSE ISSEQGDVGV CIIPHVHSKD KSHIPSSLDN VNHKIVHECQ 2050 2060 2070 2080 2090 2100 ELSSPVITTS PASFEENKIV LEEQSSREEI SLMEKVKENA TPTRNTISKV TSNLRIRSRL 2110 2120 2130 2140 2150 2160 AKPKPNLEKT LGTNRLDDYQ EVSSLCVTKG AEMETQRETE KNASKATELE NKNLGPVTTA 2170 2180 2190 2200 2210 2220 ENKDQSKLAC VHGIKGTSIS SEVNLTERNE NQEESSQEVH MLSVAPVASS ETGPCTLGLD 2230 2240 2250 RGLGENSVEE PQIKDSKGDS VLTLPVPEVK ECTV
	Isoform 3 [UniParc]. Checksum: CA5A8B8025222C59	FASTA	1,388	156,401
	10 20 30 40 50 60 MFRRARLSVK PNVRPGVGAR GSTASNPQRG RESPRPPDPA TDSASKPAEP TDVPTVDFGG 70 80 90 100 110 120 AEPQEKAPRS STEKTGGDND VEESSRSSST VSQRRKRISS TSSLVKSSVS VPSESHPLST 130 140 150 160 170 180 INQEAPQPTA TSTKEKQPCS DRYRIYKAQK LREMLKEELR KEKKQWKNKY AINESQRPPD 190 200 210 220 230 240 RSKMTMRDFI YYLPDNNPMT SSLEQEKKTE KPSTPVQTRE QEGKSTPNAE DNEMEEETDD 250 260 270 280 290 300 GPLLVPRVKV AEDGSIILDE ESLTVEVLRT KGPCVVEEND PIFERGSTTT YSSFRKNYYS 310 320 330 340 350 360 KPWSNKETDM FFLAISMVGT DFSMIGQLFP HRARIEIKNK FKREEKTNGW RIDKAFQEKR 370 380 390 400 410 420 PFDFDFFAHL LQKVLAEEEK RKQKSVKNHS LKEKKSTKPR KNVKVKKVAC EGVNNDPDES 430 440 450 460 470 480 MSSRISDTER SQKDAQTVEE ESLTLSREDA EQVALEVDLN QKKRRRKKQD GANELGVNNL 490 500 510 520 530 540 LENATVQAGP SKGEKHKNKC QAIRPELKEG ECSKEQMLSC TQNIDGIVGF ASTEKVEKRT 550 560 570 580 590 600 DPILSLSNQQ DATSVATESS ESSTSDLPSF EVGIRALCEV NNAEGSCIEE RNVDLKNNSL 610 620 630 640 650 660 EIDQTENVKP MLRGRFQRPK PNLSRAGKKS VLSQGKTESE SKNSHSKTSV EKNHVEKDKM 670 680 690 700 710 720 NTLDILRMET TERENPEAET VSVLGEKNCL QEGSQLKALR PVQVRGRLQK PKPNAGKAAE 730 740 750 760 770 780 RKEILISQEE IGANVEKNEN ESCADRDTPQ HMEDQSRKDF EEEDVILQPE KNDSFQNVQP 790 800 810 820 830 840 DEPKVLNECL SVQENNKANK LNQVPILRTR FQKPKPNIGR GTGRREISSK EEVLEKILVS 850 860 870 880 890 900 GEMAAALRET VRLDTSPKEM VPAEINTKEM QSDLKETGRR AISPREKILD VIDDTIEMET 910 920 930 940 950 960 GLKAMGREIC LREKTPEVID ATEEIDKDLE EAGRREISPQ KNGPEEVKPL GEVETDLKAT 970 980 990 1000 1010 1020 GNESSPREKT PEVTDATEEI DKNLEETGRR KISPRENGPE EVKPVDEMET DLNATGRESS 1030 1040 1050 1060 1070 1080 PREKTPEVID ATEEIDLEET EREVSPQENG LEEVKPLGEM ETDLKATGRD SFPRGKTPEV 1090 1100 1110 1120 1130 1140 IDAIEEIEID LEETEREISP QENGLEEVKP LGEMQTDLKA TGREISPREK TPEVIDATEE 1150 1160 1170 1180 1190 1200 IDKDLEETGR REISPEENGP EEVKPVDEME TDLKTTGREG SSREKTREVI DAAEVIETDL 1210 1220 1230 1240 1250 1260 EETEREISPQ ENGPEEVKPV GKMETDLKEI REEISQREKV LAEFSAIREK EIDLKETGKR 1270 1280 1290 1300 1310 1320 DIPIMEKVSG KMAVVEEMEA DLKETGKENF RERGSEEICV TEEKVAELKQ TGKTDISPRE 1330 1340 1350 1360 1370 1380 NELEETSTSR QTDTHLMQSG SNDFSAVPSL DIQVCIFLSF KSFLNAFSEE INNSMIILSL SPTTLKNL
	Isoform 4 [UniParc]. Checksum: E9E1E54C426362F8	FASTA	1,372	154,704
	10 20 30 40 50 60 MFRRARLSVK PNVRPGVGAR GSTASNPQRG RESPRPPDPA TDSASKPAEP TDVPTVDFGG 70 80 90 100 110 120 AEPQEKAPRS STEKTGGDND VEESSRSSST VSQRRKRISS TSSLVKSSVS VPSESHPLST 130 140 150 160 170 180 INQEAPQPTA TSTKEKQPCS DRYRIYKAQK LREMLKEELR KEKKQWKNKY AINESQRPPD 190 200 210 220 230 240 RSKMTMRDFI YYLPDNNPMT SSLEQEKKTE KPSTPVQTRE QEGKSTPNAE DNEMEEETDD 250 260 270 280 290 300 GPLLVPRVKV AEDGSIILDE ESLTVEVLRT KGPCVVEEND PIFERGSTTT YSSFRKNYYS 310 320 330 340 350 360 KPWSNKETDM FFLAISMVGT DFSMIGQLFP HRARIEIKNK FKREEKTNGW RIDKAFQEKR 370 380 390 400 410 420 PFDFDFFAHL LQKVLAEEEK RKQKSVKNHS LKEKKSTKPR KNVKVKKVAC EGVNNDPDES 430 440 450 460 470 480 MSSRISDTER SQKDAQTVEE ESLTLSREDA EQVALEVDLN QKKRRRKKQD GANELGVNNL 490 500 510 520 530 540 LENATVQAGP SKGEKHKNKC QAIRPELKEG ECSKEQMLSC TQNIDGIVGF ASTEKVEKRT 550 560 570 580 590 600 DPILSLSNQQ DATSVATESS ESSTSDLPSF EVGIRALCEV NNAEGSCIEE RNVDLKNNSL 610 620 630 640 650 660 EIDQTENVKP MLRGRFQRPK PNLSRAGKKS VLSQGKTESE SKNSHSKTSV EKNHVEKDKM 670 680 690 700 710 720 NTLDILRMET TERENPEAET VSVLGEKNCL QEGSQLKALR PVQVRGRLQK PKPNAGKAAE 730 740 750 760 770 780 RKEILISQEE IGANVEKNEN ESCADRDTPQ HMEDQSRKDF EEEDVILQPE KNDSFQNVQP 790 800 810 820 830 840 DEPKVLNECL SVQENNKANK LNQVPILRTR FQKPKPNIGR GTGRREISSK EEVLEKILVS 850 860 870 880 890 900 GEMAAALRET VRLDTSPKEM VPAEINTKEM QSDLKETGRR AISPREKILD VIDDTIEMET 910 920 930 940 950 960 GLKAMGREIC LREKTPEVID ATEEIDKDLE EAGRREISPQ KNGPEEVKPL GEVETDLKAT 970 980 990 1000 1010 1020 GNESSPREKT PEVTDATEEI DKNLEETGRR KISPRENGPE EVKPVDEMET DLNATGRESS 1030 1040 1050 1060 1070 1080 PREKTPEVID ATEEIDLEET EREVSPQENG LEEVKPLGEM ETDLKATGRD SFPRGKTPEV 1090 1100 1110 1120 1130 1140 IDAIEEIEID LEETEREISP QENGLEEVKP LGEMQTDLKA TGREISPREK TPEVIDATEE 1150 1160 1170 1180 1190 1200 IDKDLEETGR REISPEENGP EEVKPVDEME TDLKTTGREG SSREKTREVI DAAEVIETDL 1210 1220 1230 1240 1250 1260 EETEREISPQ ENGPEEVKPV GKMETDLKEI REEISQREKV LAEFSAIREK EIDLKETGKR 1270 1280 1290 1300 1310 1320 DIPIMEKVSG KMAVVEEMEA DLKETGKENF RERGSEEICV TEEKVAELKQ TGKTDISPRE 1330 1340 1350 1360 1370 NELEETSTSR QTDTHLMQSG SNDFSAVPSL DIQVCIFLSF KSFLNAFFRG NK
	Isoform 5 [UniParc]. Checksum: B0472F9FC6FB6897	FASTA	778	87,789
	10 20 30 40 50 60 MLRGRFQRPK PNLSRAGKKS VLSQGKTESE SKNSHSKTSV EKNHVEKDKM NTLDILRMET 70 80 90 100 110 120 TERENPEAET VSVLGEKNCL QEGSQLKALR PVQVRGRLQK PKPNAGKAAE RKEILISQEE 130 140 150 160 170 180 IGANVEKNEN ESCADRDTPQ HMEDQSRKDF EEEDVILQPE KNDSFQNVQP DEPKVLNECL 190 200 210 220 230 240 SVQENNKANK LNQVPILRTR FQKPKPNIGR GTGRREISSK EEVLEKILVS GEMAAALRET 250 260 270 280 290 300 VRLDTSPKEM VPAEINTKEM QSDLKETGRR AISPREKILD VIDDTIEMET GLKAMGREIC 310 320 330 340 350 360 LREKTPEVID ATEEIDKDLE EAGRREISPQ KNGPEEVKPL GEVETDLKAT GNESSPREKT 370 380 390 400 410 420 PEVTDATEEI DKNLEETGRR KISPRENGPE EVKPVDEMET DLNATGRESS PREKTPEVID 430 440 450 460 470 480 ATEEIDLEET EREVSPQENG LEEVKPLGEM ETDLKATGRD SFPRGKTPEV IDAIEEIEID 490 500 510 520 530 540 LEETEREISP QENGLEEVKP LGEMQTDLKA TGREISPREK TPEVIDATEE IDKDLEETGR 550 560 570 580 590 600 REISPEENGP EEVKPVDEME TDLKTTGREG SSREKTREVI DAAEVIETDL EETEREISPQ 610 620 630 640 650 660 ENGPEEVKPV GKMETDLKEI REEISQREKV LAEFSAIREK EIDLKETGKR DIPIMEKVSG 670 680 690 700 710 720 KMAVVEEMEA DLKETGKENF RERGSEEICV TEEKVAELKQ TGKTDISPRE NELEETSTSR 730 740 750 760 770 QTDTHLMQSG SNDFSAVPSL DIQVCIFLSF KSFLNAFSEE INNSMIILSL SPTTFKNL
	Isoform 6 [UniParc]. Checksum: 006AAB63089EB64F	FASTA	2,604	291,768
	10 20 30 40 50 60 MFRRARLSVK PNVRPGVGAR GSTASKPAEP TDVPTVDFGG AEPQEKAPRS STEKTGGDND 70 80 90 100 110 120 VEESSRSSST VSQRRKRISS TSSLVKSSVS VPSESHPLST INQEAPQPTA TSTKEKQPCS 130 140 150 160 170 180 DRYRIYKAQK LREMLKEELR KEKKQWKNKY AINESQRPPD RSKMTMRDFI YYLPDNNPMT 190 200 210 220 230 240 SSLEQEKKTE KPSTPVQTRE QEGKSTPNAE DNEMEEETDD GPLLVPRVKV AEDGSIILDE 250 260 270 280 290 300 ESLTVEVLRT KGPCVVEEND PIFERGSTTT YSSFRKNYYS KPWSNKETDM FFLAISMVGT 310 320 330 340 350 360 DFSMIGQLFP HRARIEIKNK FKREEKTNGW RIDKAFQEKR PFDFDFFAHL LQKVLAEEEK 370 380 390 400 410 420 RKQKSVKNHS LKEKKSTKPR KNVKVKKVAC EGVNNDPDES MSSRISDTER SQKDAQTVEE 430 440 450 460 470 480 ESLTLSREDA EQVALEVDLN QKKRRRKKQD GANELGVNNL LENATVQAGP SKGEKHKNKC 490 500 510 520 530 540 QAIRPELKEG ECSKEQMLSC TQNIDGIVGF ASTEKVEKRT DPILSLSNQQ DATSVATESS 550 560 570 580 590 600 ESSTSDLPSF EVGIRALCEV NNAEGSCIEE RNVDLKNNSL EIDQTENVKP MLRGRFQRPK 610 620 630 640 650 660 PNLSRAGKKS VLSQGKTESE SKNSHSKTSV EKNHVEKDKM NTLDILRMET TERENPEAET 670 680 690 700 710 720 VSVLGEKNCL QEGSQLKALR PVQVRGRLQK PKPNAGKAAE RKEILISQEE IGANVEKNEN 730 740 750 760 770 780 ESCADRDTPQ HMEDQSRKDF EEEDVILQPE KNDSFQNVQP DEPKVLNECL SVQENNKANK 790 800 810 820 830 840 LNQVPILRTR FQKPKPNIGR GTGRREISSK EEVLEKILVS GEMAAALRET VRLDTSPKEM 850 860 870 880 890 900 VPAEINTKEM QSDLKETGRR AISPREKILD VIDDTIEMET GLKAMGREIC LREKTPEVID 910 920 930 940 950 960 ATEEIDKDLE EAGRREISPQ KNGPEEVKPL GEVETDLKAT GNESSPREKT PEVTDATEEI 970 980 990 1000 1010 1020 DKNLEETGRR KISPRENGPE EVKPVDEMET DLNATGRESS PREKTPEVID ATEEIDLEET 1030 1040 1050 1060 1070 1080 EREVSPQENG LEEVKPLGEM ETDLKATGRD SFPRGKTPEV IDAIEEIEID LEETEREISP 1090 1100 1110 1120 1130 1140 QENGLEEVKP LGEMQTDLKA TGREISPREK TPEVIDATEE IDKDLEETGR REISPEENGP 1150 1160 1170 1180 1190 1200 EEVKPVDEME TDLKTTGREG SSREKTREVI DAAEVIETDL EETEREISPQ ENGPEEVKPV 1210 1220 1230 1240 1250 1260 GKMETDLKEI REEISQREKV LAEFSAIREK EIDLKETGKR DIPIMEKVSG KMAVVEEMEA 1270 1280 1290 1300 1310 1320 DLKETGKENF RERGSEEICV TEEKVAELKQ TGKTDISPRE NELEETSTSR QTDTHLMQSG 1330 1340 1350 1360 1370 1380 SNDFSAVPSL DIQNISSEVL SMMHTPVEEK RNSEKEVSSH FSHFKISSQT HESDKTEVQG 1390 1400 1410 1420 1430 1440 IQSPDVPEQF SDINLSKSLP QEQKPLEIKP APFVRSRFKR PKPNLARAAL KRETTESEKY 1450 1460 1470 1480 1490 1500 IYEKKSETKK METIVMQENN EQTDTLPSQH DEASLMISRE KDTLGHRNEE AVILPCTQTE 1510 1520 1530 1540 1550 1560 RNLSPSNSCE PKEESQSAPV QKNDSVVSVG TNNVNTFQQE MKESVIQTAR QVRGRLQRPR 1570 1580 1590 1600 1610 1620 PNIRKTGQRQ IVDKGEAKGI IKEGRTILPK DETEKKVLTV SNSQIETEIE VPSSAVPEHR 1630 1640 1650 1660 1670 1680 MYENQSQVVL VENLHVNKTN ETIRHENKPY VPSSAQMTRR KFQKAKPNLG RAHSKKEEPV 1690 1700 1710 1720 1730 1740 LEKVTTDQSK EGKPEDHLLQ KGASNTQLLL KEKAELLTSL EVSARKDCVG SKESALAKID 1750 1760 1770 1780 1790 1800 AELEEVGPSR RVGEETVGDN SPSSVVEEQY LNKLTSCPQP LNETSYSKIA LDGKTTISST 1810 1820 1830 1840 1850 1860 SEYERNRGER RSHKKFKPNV TRGRGSKRVR GKTSKKEPRA SKAMLVTLRA SQEEDDDADD 1870 1880 1890 1900 1910 1920 FESDYEEESY HLAPEEVNKA PVFVPVGLRS PEPVSAQIEE TMEELEITVN VPDVGCIAVV 1930 1940 1950 1960 1970 1980 EHELPNTDVT TEEMKQEENL SVPFEMTTSE HIQDEPGTND GSTEAAITLL TMGDLVLQSE 1990 2000 2010 2020 2030 2040 ISSEQGDVGV CIIPHVHSKD KSHIPSSLDN VNHKIVHECQ ELSSPVITTS PASFEENKIV 2050 2060 2070 2080 2090 2100 LEEQSSREEI SLMEKVKENA TPTRNTISKV TSNLRIRSRL AKPKPNLEKT LGTNRLDDYQ 2110 2120 2130 2140 2150 2160 EVSSLCVTKG AEMETQRETE KNASKATELE NKNLGPVTTA ENKDQSKLAC VHGIKGTSIS 2170 2180 2190 2200 2210 2220 SEVNLTERNE NQEESSQEVH MLSVAPVASS ETGPCTLGLD RGLGENSVEE PQIKDSKGDS 2230 2240 2250 2260 2270 2280 VLTLPVPEYT PTSIPEVQQE NIINPQDLTV NLVANVPQDG EDEQAFILTL VEIPANAVEE 2290 2300 2310 2320 2330 2340 FTDATAQFMP NPLLPAPILV KSVNTEERGD MSICLPATSV GQDAMGLSIS GRDNSKKPPD 2350 2360 2370 2380 2390 2400 NLDLVSRKRF QCRLDKNDHI PPAKKRSLTL RDDCQEYTTE VHSKELTNVF EETGESHKGQ 2410 2420 2430 2440 2450 2460 DIFLTSGSTL TTPEPQRQQV EAAFQSRGSR SPDACMDKNV PQLPQDEMIV SDKEERTDAA 2470 2480 2490 2500 2510 2520 PKSQQMDSRT SSSKASLSRP GRRPLGFLSL ICSKNSLESD EPMQVHSKKR LKPLIPGLRK 2530 2540 2550 2560 2570 2580 KLKRSNPFNE SQEKNRESSD LLPSPSVITT QSENISSSAT QVSCDQPLLK EGYKSAQKRA 2590 2600 PQGEATTVSE YFFNDIFIEV DETE
	Isoform 7 [UniParc]. Checksum: F159FF75502B6844	FASTA	2,552	286,185
	10 20 30 40 50 60 MFRRARLSVK PNVRPGVGAR GSTASNPQRG RESPRPPDPA TDSASKPAEP TDVPTVDFGG 70 80 90 100 110 120 AEPQEKAPRS STEKTGGDND VEESSRSSST VSQRRKRISS TSSLVKSSVS VPSESHPLST 130 140 150 160 170 180 INQEAPQPTA TSTKEKQPCS DRYRIYKAQK LREMLKEELR KEKKQWKNKY AINESQRPPD 190 200 210 220 230 240 RSKMTMRDFI YYLPDNNPMT SSLEQEKKTE KPSTPVQTRE QEGKSTPNAE DNEMEEETDD 250 260 270 280 290 300 GPLLVPRVKV AEDGSIILDE ESLTVEVLRT KGPCVVEEND PIFERGSTTT YSSFRKNYYS 310 320 330 340 350 360 KPWSNKETDM FFLAISMVGT DFSMIGQLFP HRARIEIKNK FKREEKTNGW RIDKAFQEKR 370 380 390 400 410 420 PFDFDFFAHL LQKVLAEEEK RKQKSVKNHS LKEKKSTKPR KNVKVKKVAC EGVNNDPDES 430 440 450 460 470 480 MSSRISDTER SQKDAQTVEE ESLTLSREDA EQVALEVDLN QKKRRRKKQD GANELGVNNL 490 500 510 520 530 540 LENATVQAGP SKGEKHKNKC QAIRPELKEG ECSKEQMLSC TQNIDGIVGF ASTEKVEKRT 550 560 570 580 590 600 DPILSLSNQQ DATSVATESS ESSTSDLPSF EVGIRALCEV NNAEGSCIEE RNVDLKNNSL 610 620 630 640 650 660 EIDQTENVKP MLRGRFQRPK PNLSRAGKKS VLSQGKTESE SKNSHSKTSV EKNHVEKDKM 670 680 690 700 710 720 NTLDILRMET TERENPEAET VSVLGEKNCL QEGSQLKALR PVQVRGRLQK PKPNAGKAAE 730 740 750 760 770 780 RKEILISQEE IGANVEKNEN ESCADRDTPQ HMEDQSRKDF EEEDVILQPE KNDSFQNVQP 790 800 810 820 830 840 DEPKVLNECL SVQENNKANK LNQVPILRTR FQKPKPNIGR GTGRREISSK EEVLEKILVS 850 860 870 880 890 900 GEMAAALRET VRLDTSPKEM VPAEINTKEM QSDLKETGRR AISPREKILD VIDDTIEMET 910 920 930 940 950 960 GLKAMGREIC LREKTPEVID ATEEIDKDLE EAGRREISPQ KNGPEEVKPL GEVETDLKAT 970 980 990 1000 1010 1020 GNESSPREKT PEVTDATEEI DKNLEETGRR KISPRENGPE EVKPVDEMET DLNATGRESS 1030 1040 1050 1060 1070 1080 PREKTPEVID ATEEIDLEET EREVSPQENG LEEVKPLGEM ETDLKATGRD SFPRGKTPEV 1090 1100 1110 1120 1130 1140 IDAIEEIEID LEETEREISP QENGLEEVKP LGEMQTDLKA TGREISPREK TPEVIDATEE 1150 1160 1170 1180 1190 1200 IDKDLEETGR REISPEENGP EEVKPVDEME TDLKTTGREG SSREKTREVI DAAEVIETDL 1210 1220 1230 1240 1250 1260 EETEREISPQ ENGPEEVKPV GKMETDLKEI REEISQREKV LAEFSAIREK EIDLKETGKR 1270 1280 1290 1300 1310 1320 DIPIMEKVSG KMAVVEEMEA DLKETGKENF RERGSEEICV TEEKVAELKQ TGKTDISPRE 1330 1340 1350 1360 1370 1380 NELEETSTSR QTDTHLMQSG SNDFSAVPSL DIQNISSEVL SMMHTPVEEK RNSEKEVSSH 1390 1400 1410 1420 1430 1440 FSHFKISSQT HESDKTEVQG IQSPDVPEQF SDINLSKSLP QEQKPLEIKP APFVRSRFKR 1450 1460 1470 1480 1490 1500 PKPNLARAAL KRETTESEKY IYEKKSETKK METIVMQENN EQTDTLPSQH DEASLMISRE 1510 1520 1530 1540 1550 1560 KDTLGHRNEE AVILPCTQTE RNLSPSNSCE PKEESQSAPV QKNDSVVSVG TNNVNTFQQE 1570 1580 1590 1600 1610 1620 MKESVIQTAR QVRGRLQRPR PNIRKTGQRQ IVDKGEAKGI IKEGRTILPK DETEKKVLTV 1630 1640 1650 1660 1670 1680 SNSQIETEIE VPSSAVPEHR MYENQSQVVL VENLHVNKTN ETIRHENKPY VPSSAQMTRR 1690 1700 1710 1720 1730 1740 KFQKAKPNLG RAHSKKEEPV LEKVTTDQSK EGKPEDHLLQ KGASNTQLLL KEKAELLTSL 1750 1760 1770 1780 1790 1800 EVSARKDCVG SKESALAKID AELEEVGPSR RVGEETVGDN SPSSVVEEQY LNKLTSCPQP 1810 1820 1830 1840 1850 1860 LNETSYSKIA LDGKTTISST SEYERNRGER RSHKKFKPNV TRGRGSKRVR GKTSKKEPRA 1870 1880 1890 1900 1910 1920 SKAMLVTLRA SQEEDDDADD FESDYEEESY HLAPEEVNKA PVFVPVGLRS PEPVSAQIEE 1930 1940 1950 1960 1970 1980 TMEELEITVN VPDVGCIAVV EHELPNTDVT TEEMKQEENL SVPFEMTTSE HIQDEPGVCI 1990 2000 2010 2020 2030 2040 IPHVHSKDKS HIPSSLDNVN HKIVHECQEL SSPVITTSPA SFEENKIVLE EQSSREEISL 2050 2060 2070 2080 2090 2100 MEKVKENATP TRNTISKVTS NLRIRSRLAK PKPNLEKTLG TNRLDDYQEV SSLCVTKGAE 2110 2120 2130 2140 2150 2160 METQRETEKN ASKATELENK NLGPVTTAEN KDQSKLACVH GIKGTSISSE VNLTERNENQ 2170 2180 2190 2200 2210 2220 EESSQEVHML SVAPVASSET GPCTLGLDRG LGENSVEEPQ IKDSKGDSVL TLPVPEYTPT 2230 2240 2250 2260 2270 2280 SIPEVQQENI INPQDLTVNL VANVPQDGED EQAFILTLVE IPANAVEEFT DATAQFMPNP 2290 2300 2310 2320 2330 2340 LLPAPILVKS VNTEERGDMS ICLPATSVGQ DAMGLSISGR DNSKKPPDNL DLVSRKRFQC 2350 2360 2370 2380 2390 2400 RLDKNDHIPP AKKRSLTLRD DCQEYTTEVH SKELTNVFEE TGESHKGQDI FLTSGSTLTT 2410 2420 2430 2440 2450 2460 PEPQRQQVEA AFQSRGSRSP DACMDKNVPQ LPQDEMIVSD KEERTDAAPK SQQMDSRTSS 2470 2480 2490 2500 2510 2520 SKASLSRPGR RPLGFLSLIC SKNSLESDEP MQVHSKKRLK PLIPGLRKKL KRSNPFNESQ 2530 2540 2550 EKNRESSDLL PSPSVITTQS ENISSSATQR PF
	Isoform 8 [UniParc]. Checksum: 054AFA93526C7083	FASTA	463	51,420
	10 20 30 40 50 60 MLVTLRASQE EDDDADDFES DYEEESYHLA PEEVNKAPVF VPVGLRSPEP VSAQIEETME 70 80 90 100 110 120 ELEITVNVPD VGCIAVVEHE LPNTDVTTEE MKQEENLSVP FEMTTSEHIQ DEPGTNDGST 130 140 150 160 170 180 EAAITLLTMG DLVLQSEISS EQGDGVCIIP HVHSKDKSHI PSSLDNVNHK IVHECQELSS 190 200 210 220 230 240 PVITTSPASF EENKIVLEEQ SSREEISLME KVKENATPTR NTISKVTSNL RIRSRLAKPK 250 260 270 280 290 300 PNLEKTLGTN RLDDYQEVSS LCVTKGAEME TQRETEKNAS KATELENKNL GPVTTAENKD 310 320 330 340 350 360 QSKLACVHGI KGTSISSEVN LTERNENQEE SSQEVHMLSV APVASSETGP CTLGLDRGLG 370 380 390 400 410 420 ENSVEEPQIK DSKGDSVLTL PVPEYTPTSI PEVQQENIIN PQDLTVFVYQ QLQLVKMPWV 430 440 450 460 YLFLEEIILK SRLIIWILYL GRDFNAGLIK MTTFLLPKNV HSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters." Schramm L., Pendergrast P.S., Sun Y., Hernandez N. Genes Dev. 14:2650-2663(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), FUNCTION, VARIANTS GLU-38 AND MET-1347.
[2]	"The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1." Kelter A.R., Herchenbach J., Wirth B. Genomics 70:315-326(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-2187 (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2189-2624 (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS GLU-38; MET-1347 AND LEU-2013.
[3]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANTS CYS-757; MET-1264 AND MET-1347. Tissue: Brain.
[4]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-38; CYS-757; ILE-1244; MET-1264; MET-1347 AND GLU-1469. Tissue: Brain.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1947-2624 (ISOFORM 7), VARIANT LEU-2013. Tissue: Testis.
[7]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-38; CYS-757; ILE-1244; MET-1264; MET-1347 AND GLU-1469. Tissue: Lung.
[9]	"Molecular cloning and functional characterization of human TFIIIB 150." Teichmann M., Wang Z., Ito M., Seifart K.H., Roeder R.G. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-881 (ISOFORM 1).
[10]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-655 (ISOFORM 6). Tissue: Brain.
[11]	"A stable complex of a novel transcription factor IIB- related factor, human TFIIIB50, and associated proteins mediate selective transcription by RNA polymerase III of genes with upstream promoter elements." Teichmann M., Wang Z., Roeder R.G. Proc. Natl. Acad. Sci. U.S.A. 97:14200-14205(2000) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF TFIIIB-ALPHA COMPLEX.
[12]	"TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo." Fairley J.A., Scott P.H., White R.J. EMBO J. 22:5841-5850(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH BRF1.
[13]	"Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB', is an essential component of human TFIIIC1 activity." Weser S., Gruber C., Hafner H.M., Teichmann M., Roeder R.G., Seifart K.H., Meissner W. J. Biol. Chem. 279:27022-27029(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF TFIIIC1 COMPLEX.
[14]	"CK2 phosphorylation of Bdp1 executes cell cycle-specific RNA polymerase III transcription repression." Hu P., Samudre K., Wu S., Sun Y., Hernandez N. Mol. Cell 16:81-92(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION, MUTAGENESIS OF SER-390; SER-426; SER-431; THR-437 AND SER-446.
[15]	"The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB." Schoenen F., Wirth B. Biol. Chem. 387:277-284(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ZBTB43.
[16]	"A role for Yin Yang-1 (YY1) in the assembly of snRNA transcription complexes." Emran F., Florens L., Ma B., Swanson S.K., Washburn M.P., Hernandez N. Gene 377:96-108(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[17]	"Epstein-Barr virus induces cellular transcription factors to allow active expression of EBER genes by RNA polymerase III." Felton-Edkins Z.A., Kondrashov A., Karali D., Fairley J.A., Dawson C.W., Arrand J.R., Young L.S., White R.J. J. Biol. Chem. 281:33871-33880(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[18]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-915, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF298151 mRNA. Translation: AAG30220.1. AF298152 mRNA. Translation: AAG30221.1. AJ238520 mRNA. Translation: CAC04245.1. AJ278892 Genomic DNA. Translation: CAC17771.1. AJ279120 , AJ279121, AJ279122, AJ279123, AJ279124, AJ279125, AJ279126, AJ279127, AJ279128, AJ279129, AJ279130, AJ279131, AJ279132, AJ279133, AJ279134, AJ279135, AJ279136, AJ279137, AJ279138, AJ279139, AJ279140, AJ279141, AJ279142, AJ279143, AJ279144, AJ279145, AJ279146, AJ279147, AJ279148, AJ279149, AJ279150 Genomic DNA. Translation: CAC21448.1. AB033067 mRNA. Translation: BAA86555.1. Different initiation. AB051476 mRNA. Translation: BAB21780.3. Different initiation. BX641011 mRNA. Translation: CAE46010.1. CR749229 mRNA. Translation: CAH18085.1. Different initiation. CR749289 mRNA. Translation: CAH18144.1. AC138832 Genomic DNA. No translation available. BC032146 mRNA. Translation: AAH32146.1. Sequence problems. BC146792 mRNA. Translation: AAI46793.1. AF176695 mRNA. Translation: AAG09268.1. Frameshift. AK057871 mRNA. Translation: BAB71602.1.
IPI	IPI00470932. IPI00760877. IPI00872938. IPI00893156. IPI00893272. IPI00893280. IPI00893915. IPI00894056.
RefSeq	NP_060899.2. NM_018429.2.
UniGene	Hs.258272.
3D structure databases
ProteinModelPortal	A6H8Y1.
ModBase	Search...
Protein-protein interaction databases
IntAct	A6H8Y1. 2 interactions.
PTM databases
PhosphoSite	A6H8Y1.
Proteomic databases
PaxDb	A6H8Y1.
PRIDE	A6H8Y1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358731; ENSP00000351575; ENSG00000145734. ENST00000380675; ENSP00000370050; ENSG00000145734. ENST00000573110; ENSP00000460502; ENSG00000261932.
GeneID	55814.
KEGG	hsa:55814.
UCSC	uc003kbn.1. human. uc003kbo.3. human. uc003kbp.1. human.
Organism-specific databases
CTD	55814.
GeneCards	GC05P070787.
H-InvDB	HIX0004927.
HGNC	HGNC:13652. BDP1.
MIM	607012. gene.
neXtProt	NX_A6H8Y1.
PharmGKB	PA25336.
HUGE	Search... Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5118.
HOVERGEN	HBG107497.
InParanoid	A6H8Y1.
KO	K15198.
OMA	KNENESC.
PhylomeDB	A6H8Y1.
Enzyme and pathway databases
Reactome	REACT_1788. Transcription. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	A6H8Y1.
Bgee	A6H8Y1.
CleanEx	HS_BDP1.
Genevestigator	A6H8Y1.
Family and domain databases
InterPro	IPR009057. Homeodomain-like. IPR001005. SANT/Myb. [Graphical view]
SMART	SM00717. SANT. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS50090. MYB_LIKE. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	BDP1. human.
GenomeRNAi	55814.
NextBio	60990.
SOURCE	Search...

Entry information

Entry name

BDP1_HUMAN

Accession

Primary (citable) accession number: A6H8Y1
Secondary accession number(s): Q68DS6 , Q68DY5, Q6MZL9, Q6PIM7, Q86W98, Q96LR8, Q9C0H4, Q9H197, Q9H1A1, Q9HAW1, Q9HAW2, Q9HCY0, Q9ULH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 56 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.