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Protein
Submitted name:

Intersectin 2

Gene

ITSN2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi66 – 77PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Intersectin 2Imported
Gene namesi
Name:ITSN2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29982

PTM / Processingi

Proteomic databases

PeptideAtlasiA6H8W8
PRIDEiA6H8W8

Expressioni

Gene expression databases

GenevisibleiA6H8W8 HS

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA6H8W8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 109EHInterPro annotationAdd BLAST89
Domaini53 – 88EF-handInterPro annotationAdd BLAST36
Domaini243 – 332EHInterPro annotationAdd BLAST90
Domaini276 – 311EF-handInterPro annotationAdd BLAST36
Domaini729 – 790SH3InterPro annotationAdd BLAST62
Domaini870 – 928SH3InterPro annotationAdd BLAST59
Domaini953 – 1011SH3InterPro annotationAdd BLAST59
Domaini1025 – 1089SH3InterPro annotationAdd BLAST65
Domaini1099 – 1158SH3InterPro annotationAdd BLAST60
Domaini1181 – 1367DHInterPro annotationAdd BLAST187
Domaini1406 – 1516PHInterPro annotationAdd BLAST111
Domaini1542 – 1624C2InterPro annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili367 – 500Sequence analysisAdd BLAST134
Coiled coili508 – 549Sequence analysisAdd BLAST42
Coiled coili584 – 664Sequence analysisAdd BLAST81
Coiled coili677 – 726Sequence analysisAdd BLAST50
Coiled coili1354 – 1374Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1029 Eukaryota
KOG4305 Eukaryota
COG5422 LUCA
HOGENOMiHOG000010175
HOVERGENiHBG052159
KOiK20045

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd11988 SH3_Intersectin2_1, 1 hit
cd11990 SH3_Intersectin2_2, 1 hit
cd11992 SH3_Intersectin2_3, 1 hit
cd11994 SH3_Intersectin2_4, 1 hit
cd11996 SH3_Intersectin2_5, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
IPR027029 Intersectin-2
IPR035737 Intersectin-2_SH3_1
IPR035738 Intersectin-2_SH3_2
IPR035739 Intersectin-2_SH3_3
IPR035740 Intersectin-2_SH3_4
IPR035741 Intersectin-2_SH3_5
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR11216:SF29 PTHR11216:SF29, 4 hits
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF12763 EF-hand_4, 2 hits
PF16652 PH_13, 1 hit
PF00621 RhoGEF, 1 hit
PF00018 SH3_1, 2 hits
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 2 hits
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00054 EFh, 2 hits
SM00027 EH, 2 hits
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 5 hits
SUPFAMiSSF47473 SSF47473, 2 hits
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 5 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50010 DH_2, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS50031 EH, 2 hits
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 5 hits

Sequencei

Sequence statusi: Complete.

A6H8W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFPTAMNG GPNMWAITSE ERTKHDRQFD NLKPSGGYIT GDQARNFFLQ
60 70 80 90 100
SGLPAPVLAE IWALSDLNKD GKMDQQEFSI AMKLIKLKLQ GQQLPVVLPP
110 120 130 140 150
IMKQPPMFSP LISARFGMGS MPNLSIPQPL PPAAPITSLS SATSGTNLPP
160 170 180 190 200
LMMPTPLVPS VSTSSLPNGT ASLIQPLPIP YSSSTLPHGS SYSLMMGGFG
210 220 230 240 250
GASIQKAQSL IDLGSSSSTS STASLSGNSP KTGTSEWAVP QPTRLKYRQK
260 270 280 290 300
FNTLDKSMSG YLSGFQARNA LLQSNLSQTQ LATIWTLADV DGDGQLKAEE
310 320 330 340 350
FILAMHLTDM AKAGQPLPLT LPPELVPPSF RGGKQIDSIN GTLPSYQKMQ
360 370 380 390 400
EEEPQKKLPV TFEDKRKANY ERGNMELEKR RQALMEQQQR EAERKAQKEK
410 420 430 440 450
EEWERKQREL QEQEWKKQLE LEKRLEKQRE LERQREEERR KDIERREAAK
460 470 480 490 500
QELERQRRLE WERIRRQELL NQKNREQEEI VRLNSKKKNL HLELEALNGK
510 520 530 540 550
HQQISGRLQD VRLKKQTQKT ELEVLDKQCD LEIMEIKQLQ QELQEYQNKL
560 570 580 590 600
IYLVPEKQLL NERIKNMQFS NTPDSGVSLL HKKSLEKEEL CQRLKEQLDA
610 620 630 640 650
LEKETASKLS EMDSFNNQLK ELRETYNTQQ LALEQLYKIK RDKLKEIERK
660 670 680 690 700
RLELMQKKKL EDEAARKAKQ GKENLWKENL RKEEEEKQKR LQEEKTQEKI
710 720 730 740 750
QEEERKAEEK QRKDKDTLKA EEKKRETASV LVNYRALYPF EARNHDEMSF
760 770 780 790 800
NSGDIIQVDE KTVGEPGWLY GSFQGNFGWF PCNYVEKMPS SENEKAVSPK
810 820 830 840 850
KALLPPTVSL SATSTSSEPL SSNQPASVTD YQNVSFSNLT VNTSWQKKSA
860 870 880 890 900
FTRTVSPGSV SPIHGQGQVV ENLKAQALCS WTAKKDNHLN FSKHDIITVL
910 920 930 940 950
EQQENWWFGE VHGGRGWFPK SYVKIIPGSE VKREEPEALY AAVNKKPTSA
960 970 980 990 1000
AYSVGEEYIA LYPYSSVEPG DLTFTEGEEI LVTQKDGEWW TGSIGDRSGI
1010 1020 1030 1040 1050
FPSNYVKPKD QESFGSASKS GASNKKPEIA QVTSAYVASG SEQLSLAPGQ
1060 1070 1080 1090 1100
LILILKKNTS GWWQGELQAR GKKRQKGWFP ASHVKLLGPS SERATPAFHP
1110 1120 1130 1140 1150
VCQVIAMYDY AANNEDELSF SKGQLINVMN KDDPDWWQGE INGVTGLFPS
1160 1170 1180 1190 1200
NYVKMTTDSD PSQQWCADLQ TLDTMQPIER KRQGYIHELI QTEERYMADL
1210 1220 1230 1240 1250
QLVVEVFQKR MAESGFLTEG EMALIFVNWK ELIMSNTKLL KALRVRKKTG
1260 1270 1280 1290 1300
GEKMPVQMIG DILAAELSHM QAYIRFCSCQ LNGAALLQQK TDEDTDFKEF
1310 1320 1330 1340 1350
LKKLASDPRC KGMPLSSFLL KPMQRITRYP LLIRSILENT PESHADHSSL
1360 1370 1380 1390 1400
KLALERAEEL CSQVNEGVRE KENSDRLEWI QAHVQCEGLA EQLIFNSLTN
1410 1420 1430 1440 1450
CLGPRKLLHS GKLYKTKSNK ELHGFLFNDF LLLTYMVKQF AVSSGSEKLF
1460 1470 1480 1490 1500
SSKSNAQFKM YKTPIFLNEV LVKLPTDPSS DEPVFHISHI DRVYTLRTDN
1510 1520 1530 1540 1550
INERTAWVQK IKAASEQYID TEKKQREKAY QARSQKTSGI GRLMVHVIEA
1560 1570 1580 1590 1600
TELKACKPNG KSNPYCEISM GSQSYTTRTI QDTLNPKWNF NCQFFIKDLY
1610 1620 1630 1640 1650
QDVLCLTLFD RDQFSPDDFL GRTEIPVAKI RTEQESKGPM TRRLLLHEVP
1660
TGEVWVRFDL QLFEQKTLL
Length:1,669
Mass (Da):190,365
Last modified:July 24, 2007 - v1
Checksum:i8A2E0E323BAE4E2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146779 mRNA Translation: AAI46780.1
RefSeqiNP_006268.2, NM_006277.2
NP_062541.3, NM_019595.3
UniGeneiHs.432562

Genome annotation databases

GeneIDi50618
KEGGihsa:50618

Similar proteinsi

Entry informationi

Entry nameiA6H8W8_HUMAN
AccessioniPrimary (citable) accession number: A6H8W8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 25, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health