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Protein
Submitted name:

Intersectin 2

Gene

ITSN2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Intersectin 2Imported
Gene namesi
Name:ITSN2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29982.

PTM / Processingi

Proteomic databases

PaxDbiA6H8W8.

Expressioni

Gene expression databases

GenevisibleiA6H8W8. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347244.

Structurei

3D structure databases

ProteinModelPortaliA6H8W8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 10989EHInterPro annotationAdd
BLAST
Domaini53 – 8836EF-handInterPro annotationAdd
BLAST
Domaini243 – 33290EHInterPro annotationAdd
BLAST
Domaini276 – 31136EF-handInterPro annotationAdd
BLAST
Domaini729 – 79062SH3InterPro annotationAdd
BLAST
Domaini870 – 92859SH3InterPro annotationAdd
BLAST
Domaini953 – 101159SH3InterPro annotationAdd
BLAST
Domaini1025 – 108965SH3InterPro annotationAdd
BLAST
Domaini1099 – 115860SH3InterPro annotationAdd
BLAST
Domaini1181 – 1367187DH (DBL-homology)InterPro annotationAdd
BLAST
Domaini1406 – 1516111PHInterPro annotationAdd
BLAST
Domaini1542 – 162483C2InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili367 – 500134Sequence analysisAdd
BLAST
Coiled coili508 – 54942Sequence analysisAdd
BLAST
Coiled coili584 – 66481Sequence analysisAdd
BLAST
Coiled coili677 – 72650Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 5 SH3 domains.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainUniRule annotation

Phylogenomic databases

eggNOGiKOG1029. Eukaryota.
KOG4305. Eukaryota.
COG5422. LUCA.
HOGENOMiHOG000010175.
HOVERGENiHBG052159.
KOiK20045.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR027029. Intersectin-2.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR11216:SF29. PTHR11216:SF29. 5 hits.
PfamiPF00168. C2. 1 hit.
PF12763. EF-hand_4. 2 hits.
PF16652. PH_13. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6H8W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFPTAMNG GPNMWAITSE ERTKHDRQFD NLKPSGGYIT GDQARNFFLQ
60 70 80 90 100
SGLPAPVLAE IWALSDLNKD GKMDQQEFSI AMKLIKLKLQ GQQLPVVLPP
110 120 130 140 150
IMKQPPMFSP LISARFGMGS MPNLSIPQPL PPAAPITSLS SATSGTNLPP
160 170 180 190 200
LMMPTPLVPS VSTSSLPNGT ASLIQPLPIP YSSSTLPHGS SYSLMMGGFG
210 220 230 240 250
GASIQKAQSL IDLGSSSSTS STASLSGNSP KTGTSEWAVP QPTRLKYRQK
260 270 280 290 300
FNTLDKSMSG YLSGFQARNA LLQSNLSQTQ LATIWTLADV DGDGQLKAEE
310 320 330 340 350
FILAMHLTDM AKAGQPLPLT LPPELVPPSF RGGKQIDSIN GTLPSYQKMQ
360 370 380 390 400
EEEPQKKLPV TFEDKRKANY ERGNMELEKR RQALMEQQQR EAERKAQKEK
410 420 430 440 450
EEWERKQREL QEQEWKKQLE LEKRLEKQRE LERQREEERR KDIERREAAK
460 470 480 490 500
QELERQRRLE WERIRRQELL NQKNREQEEI VRLNSKKKNL HLELEALNGK
510 520 530 540 550
HQQISGRLQD VRLKKQTQKT ELEVLDKQCD LEIMEIKQLQ QELQEYQNKL
560 570 580 590 600
IYLVPEKQLL NERIKNMQFS NTPDSGVSLL HKKSLEKEEL CQRLKEQLDA
610 620 630 640 650
LEKETASKLS EMDSFNNQLK ELRETYNTQQ LALEQLYKIK RDKLKEIERK
660 670 680 690 700
RLELMQKKKL EDEAARKAKQ GKENLWKENL RKEEEEKQKR LQEEKTQEKI
710 720 730 740 750
QEEERKAEEK QRKDKDTLKA EEKKRETASV LVNYRALYPF EARNHDEMSF
760 770 780 790 800
NSGDIIQVDE KTVGEPGWLY GSFQGNFGWF PCNYVEKMPS SENEKAVSPK
810 820 830 840 850
KALLPPTVSL SATSTSSEPL SSNQPASVTD YQNVSFSNLT VNTSWQKKSA
860 870 880 890 900
FTRTVSPGSV SPIHGQGQVV ENLKAQALCS WTAKKDNHLN FSKHDIITVL
910 920 930 940 950
EQQENWWFGE VHGGRGWFPK SYVKIIPGSE VKREEPEALY AAVNKKPTSA
960 970 980 990 1000
AYSVGEEYIA LYPYSSVEPG DLTFTEGEEI LVTQKDGEWW TGSIGDRSGI
1010 1020 1030 1040 1050
FPSNYVKPKD QESFGSASKS GASNKKPEIA QVTSAYVASG SEQLSLAPGQ
1060 1070 1080 1090 1100
LILILKKNTS GWWQGELQAR GKKRQKGWFP ASHVKLLGPS SERATPAFHP
1110 1120 1130 1140 1150
VCQVIAMYDY AANNEDELSF SKGQLINVMN KDDPDWWQGE INGVTGLFPS
1160 1170 1180 1190 1200
NYVKMTTDSD PSQQWCADLQ TLDTMQPIER KRQGYIHELI QTEERYMADL
1210 1220 1230 1240 1250
QLVVEVFQKR MAESGFLTEG EMALIFVNWK ELIMSNTKLL KALRVRKKTG
1260 1270 1280 1290 1300
GEKMPVQMIG DILAAELSHM QAYIRFCSCQ LNGAALLQQK TDEDTDFKEF
1310 1320 1330 1340 1350
LKKLASDPRC KGMPLSSFLL KPMQRITRYP LLIRSILENT PESHADHSSL
1360 1370 1380 1390 1400
KLALERAEEL CSQVNEGVRE KENSDRLEWI QAHVQCEGLA EQLIFNSLTN
1410 1420 1430 1440 1450
CLGPRKLLHS GKLYKTKSNK ELHGFLFNDF LLLTYMVKQF AVSSGSEKLF
1460 1470 1480 1490 1500
SSKSNAQFKM YKTPIFLNEV LVKLPTDPSS DEPVFHISHI DRVYTLRTDN
1510 1520 1530 1540 1550
INERTAWVQK IKAASEQYID TEKKQREKAY QARSQKTSGI GRLMVHVIEA
1560 1570 1580 1590 1600
TELKACKPNG KSNPYCEISM GSQSYTTRTI QDTLNPKWNF NCQFFIKDLY
1610 1620 1630 1640 1650
QDVLCLTLFD RDQFSPDDFL GRTEIPVAKI RTEQESKGPM TRRLLLHEVP
1660
TGEVWVRFDL QLFEQKTLL
Length:1,669
Mass (Da):190,365
Last modified:July 24, 2007 - v1
Checksum:i8A2E0E323BAE4E2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146779 mRNA. Translation: AAI46780.1.
RefSeqiNP_006268.2. NM_006277.2.
NP_062541.3. NM_019595.3.
UniGeneiHs.432562.

Genome annotation databases

GeneIDi50618.
KEGGihsa:50618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146779 mRNA. Translation: AAI46780.1.
RefSeqiNP_006268.2. NM_006277.2.
NP_062541.3. NM_019595.3.
UniGeneiHs.432562.

3D structure databases

ProteinModelPortaliA6H8W8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347244.

Proteomic databases

PaxDbiA6H8W8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi50618.
KEGGihsa:50618.

Organism-specific databases

CTDi50618.
PharmGKBiPA29982.

Phylogenomic databases

eggNOGiKOG1029. Eukaryota.
KOG4305. Eukaryota.
COG5422. LUCA.
HOGENOMiHOG000010175.
HOVERGENiHBG052159.
KOiK20045.

Miscellaneous databases

ChiTaRSiITSN2. human.
GenomeRNAii50618.

Gene expression databases

GenevisibleiA6H8W8. HS.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR000219. DH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000261. EH_dom.
IPR027029. Intersectin-2.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR11216:SF29. PTHR11216:SF29. 5 hits.
PfamiPF00168. C2. 1 hit.
PF12763. EF-hand_4. 2 hits.
PF16652. PH_13. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00027. EH. 2 hits.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48065. SSF48065. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 5 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50010. DH_2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50031. EH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiA6H8W8_HUMAN
AccessioniPrimary (citable) accession number: A6H8W8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.