ID   CDHR4_HUMAN             Reviewed;         788 AA.
AC   A6H8M9; Q6UXT0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 121.
DE   RecName: Full=Cadherin-related family member 4;
DE   AltName: Full=Cadherin-like protein 29;
DE   Flags: Precursor;
GN   Name=CDHR4; Synonyms=CDH29; ORFNames=UNQ9392/PRO34300;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They
CC       preferentially interact with themselves in a homophilic manner in
CC       connecting cells; cadherins may thus contribute to the sorting of
CC       heterogeneous cell types (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A6H8M9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A6H8M9-2; Sequence=VSP_031552, VSP_031553;
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DR   EMBL; AY358221; AAQ88588.1; -; mRNA.
DR   EMBL; BC132756; AAI32757.1; -; mRNA.
DR   EMBL; BC146674; AAI46675.1; -; mRNA.
DR   CCDS; CCDS46829.1; -. [A6H8M9-1]
DR   RefSeq; NP_001007541.2; NM_001007540.3. [A6H8M9-1]
DR   AlphaFoldDB; A6H8M9; -.
DR   SMR; A6H8M9; -.
DR   BioGRID; 132983; 94.
DR   STRING; 9606.ENSP00000391409; -.
DR   GlyCosmos; A6H8M9; 1 site, No reported glycans.
DR   GlyGen; A6H8M9; 1 site.
DR   iPTMnet; A6H8M9; -.
DR   PhosphoSitePlus; A6H8M9; -.
DR   BioMuta; CDHR4; -.
DR   MassIVE; A6H8M9; -.
DR   PaxDb; 9606-ENSP00000391409; -.
DR   PeptideAtlas; A6H8M9; -.
DR   ProteomicsDB; 775; -. [A6H8M9-1]
DR   Antibodypedia; 49593; 41 antibodies from 8 providers.
DR   DNASU; 389118; -.
DR   Ensembl; ENST00000343366.8; ENSP00000341302.4; ENSG00000187492.9. [A6H8M9-2]
DR   Ensembl; ENST00000412678.7; ENSP00000391409.2; ENSG00000187492.9. [A6H8M9-1]
DR   GeneID; 389118; -.
DR   KEGG; hsa:389118; -.
DR   MANE-Select; ENST00000412678.7; ENSP00000391409.2; NM_001007540.4; NP_001007541.2.
DR   UCSC; uc003cxp.3; human. [A6H8M9-1]
DR   AGR; HGNC:34527; -.
DR   CTD; 389118; -.
DR   DisGeNET; 389118; -.
DR   GeneCards; CDHR4; -.
DR   HGNC; HGNC:34527; CDHR4.
DR   HPA; ENSG00000187492; Tissue enriched (fallopian).
DR   neXtProt; NX_A6H8M9; -.
DR   OpenTargets; ENSG00000187492; -.
DR   PharmGKB; PA165696944; -.
DR   VEuPathDB; HostDB:ENSG00000187492; -.
DR   eggNOG; KOG1219; Eukaryota.
DR   GeneTree; ENSGT00940000162824; -.
DR   HOGENOM; CLU_382923_0_0_1; -.
DR   InParanoid; A6H8M9; -.
DR   OMA; PRMEMPQ; -.
DR   OrthoDB; 5313831at2759; -.
DR   PhylomeDB; A6H8M9; -.
DR   TreeFam; TF341878; -.
DR   PathwayCommons; A6H8M9; -.
DR   BioGRID-ORCS; 389118; 9 hits in 1150 CRISPR screens.
DR   GenomeRNAi; 389118; -.
DR   Pharos; A6H8M9; Tdark.
DR   PRO; PR:A6H8M9; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; A6H8M9; Protein.
DR   Bgee; ENSG00000187492; Expressed in right uterine tube and 85 other cell types or tissues.
DR   ExpressionAtlas; A6H8M9; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 3.
DR   Gene3D; 2.60.40.60; Cadherins; 4.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   PANTHER; PTHR24026; FAT ATYPICAL CADHERIN-RELATED; 1.
DR   PANTHER; PTHR24026:SF124; PROTOCADHERIN FAT 4; 1.
DR   Pfam; PF00028; Cadherin; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 2.
DR   SUPFAM; SSF49313; Cadherin-like; 4.
DR   PROSITE; PS00232; CADHERIN_1; 1.
DR   PROSITE; PS50268; CADHERIN_2; 3.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Calcium; Cell adhesion; Glycoprotein; Membrane;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..788
FT                   /note="Cadherin-related family member 4"
FT                   /id="PRO_0000319973"
FT   TOPO_DOM        17..686
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        687..707
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        708..788
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          237..338
FT                   /note="Cadherin 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          339..449
FT                   /note="Cadherin 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          444..554
FT                   /note="Cadherin 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          551..674
FT                   /note="Cadherin 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   CARBOHYD        242
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         135
FT                   /note="A -> GEARGSRQGGGRHGLSRSSLTSTLASWGNDSGARDSHTWGSAVHSAP
FT                   PRPRTPRSAGKPRTWDGG (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12975309,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031552"
FT   VAR_SEQ         136..788
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12975309,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031553"
FT   VARIANT         5
FT                   /note="R -> K (in dbSNP:rs13072748)"
FT                   /id="VAR_039109"
SQ   SEQUENCE   788 AA;  85827 MW;  AAC5C9F6908DBF67 CRC64;
     MVLLRLLVFL FAPVVSDLCS LPCFINVSES QGPGTVLQFL SFNCSSYTPT PTLELLNVQP
     PTTFFNPPSL ARWQGTYVGK LTLSSSAQLD ALMVNHYKVQ LKFTCGNHVM EGSLSVDVQR
     DLSHIQCAGQ FASPAGEMIQ VPETVTPGAR LYTLLLPGLE LHGAQMSIIS AQDLPHFPGP
     FSINEQGWLQ APSQGLLGQA QKVFQLQISV SFGQRQSCQG MVIVKVLPVP SSQVSFLEQA
     QNITIPENLA PGSEVVQVQA RGVDLRYEIL SPVPSPLFSI GRADGVVRTT TPLELARTSG
     TAVSRLQVKA FEQGQLWASA KLNLTMNVQL VNLWPPRCLP ALLVSQIPET APVGTVLNTL
     TCEDPDSVGA TLDYKLWFRS SSNPASLCLY DRVLEVNATL DCDTPGACFQ HAASILVLDG
     GQPQMTTEVP VLVMVTPINE FSPACAPRTF RVQEDAAPHT LLGSVVGTDM DYPHDNIEYY
     TSGGPTTFAV DRLSGEVHLL GPLDYEQQRL YRLTVLVIDH GQDQNPNHHL SGSCTITIEV
     EDVNDHAPEC EPPFQELTIY APLGRSVEVT KMSCQIPQEP QRLIYSYSIV GGNSQNRFIL
     QGAILVHSDL VLGPFWPEQP RTYELLICVA DAGPSTPHLS TTATIIVHLV PRRASTVATS
     THRTTVPSTM TPMLVTDTEA FWQPQPWFVV VLTATGALLL LALGWLLGRL LQGLAQLLQA
     PSKPAQALLL NSIQGTEGSI EGFLEAPKME MSQAPSSVMS LHFDGRAQDS RTGRDYLFNT
     HTGARRWL
//