A6H8M9 (CDHR4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cadherin-related family member 4

Alternative name(s):
Cadherin-like protein 29

Gene names

Name:	CDHR4
Synonyms:	CDH29
ORF Names:	UNQ9392/PRO34300

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	788 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Contains 4 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6H8M9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A6H8M9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: A → GEARGSRQGGGRHGLSRSSLTSTLASWGNDSGARDSHTWGSAVHSAPPRPRTPRSAGKPRTWDGG
     136-788: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 788	772	Cadherin-related family member 4		PRO_0000319973
Regions
	Topological domain	17 – 686	670	Extracellular Potential
	Transmembrane	687 – 707	21	Helical; Potential
	Topological domain	708 – 788	81	Cytoplasmic Potential
	Domain	237 – 338	102	Cadherin 1
	Domain	339 – 449	111	Cadherin 2
	Domain	444 – 554	111	Cadherin 3
	Domain	551 – 674	124	Cadherin 4
Amino acid modifications
	Glycosylation	242	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	135	1	A → GEARGSRQGGGRHGLSRSSL TSTLASWGNDSGARDSHTWG SAVHSAPPRPRTPRSAGKPR TWDGG in isoform 2.		VSP_031552
	Alternative sequence	136 – 788	653	Missing in isoform 2.		VSP_031553
	Natural variant	5	1	R → K. Corresponds to variant rs13072748 [ dbSNP | Ensembl ].		VAR_039109

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: AAC5C9F6908DBF67	FASTA	788	85,827
	10 20 30 40 50 60 MVLLRLLVFL FAPVVSDLCS LPCFINVSES QGPGTVLQFL SFNCSSYTPT PTLELLNVQP 70 80 90 100 110 120 PTTFFNPPSL ARWQGTYVGK LTLSSSAQLD ALMVNHYKVQ LKFTCGNHVM EGSLSVDVQR 130 140 150 160 170 180 DLSHIQCAGQ FASPAGEMIQ VPETVTPGAR LYTLLLPGLE LHGAQMSIIS AQDLPHFPGP 190 200 210 220 230 240 FSINEQGWLQ APSQGLLGQA QKVFQLQISV SFGQRQSCQG MVIVKVLPVP SSQVSFLEQA 250 260 270 280 290 300 QNITIPENLA PGSEVVQVQA RGVDLRYEIL SPVPSPLFSI GRADGVVRTT TPLELARTSG 310 320 330 340 350 360 TAVSRLQVKA FEQGQLWASA KLNLTMNVQL VNLWPPRCLP ALLVSQIPET APVGTVLNTL 370 380 390 400 410 420 TCEDPDSVGA TLDYKLWFRS SSNPASLCLY DRVLEVNATL DCDTPGACFQ HAASILVLDG 430 440 450 460 470 480 GQPQMTTEVP VLVMVTPINE FSPACAPRTF RVQEDAAPHT LLGSVVGTDM DYPHDNIEYY 490 500 510 520 530 540 TSGGPTTFAV DRLSGEVHLL GPLDYEQQRL YRLTVLVIDH GQDQNPNHHL SGSCTITIEV 550 560 570 580 590 600 EDVNDHAPEC EPPFQELTIY APLGRSVEVT KMSCQIPQEP QRLIYSYSIV GGNSQNRFIL 610 620 630 640 650 660 QGAILVHSDL VLGPFWPEQP RTYELLICVA DAGPSTPHLS TTATIIVHLV PRRASTVATS 670 680 690 700 710 720 THRTTVPSTM TPMLVTDTEA FWQPQPWFVV VLTATGALLL LALGWLLGRL LQGLAQLLQA 730 740 750 760 770 780 PSKPAQALLL NSIQGTEGSI EGFLEAPKME MSQAPSSVMS LHFDGRAQDS RTGRDYLFNT HTGARRWL
	Isoform 2 [UniParc]. Checksum: D42B51E25AEC77AF	FASTA	199	21,388
	10 20 30 40 50 60 MVLLRLLVFL FAPVVSDLCS LPCFINVSES QGPGTVLQFL SFNCSSYTPT PTLELLNVQP 70 80 90 100 110 120 PTTFFNPPSL ARWQGTYVGK LTLSSSAQLD ALMVNHYKVQ LKFTCGNHVM EGSLSVDVQR 130 140 150 160 170 180 DLSHIQCAGQ FASPGEARGS RQGGGRHGLS RSSLTSTLAS WGNDSGARDS HTWGSAVHSA 190 PPRPRTPRSA GKPRTWDGG

References

[1]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358221 mRNA. Translation: AAQ88588.1. BC132756 mRNA. Translation: AAI32757.1. BC146674 mRNA. Translation: AAI46675.1.
IPI	IPI00397966. IPI00397967.
RefSeq	NP_001007541.2. NM_001007540.2.
UniGene	Hs.363312.
3D structure databases
ProteinModelPortal	A6H8M9.
ModBase	Search...
PTM databases
PhosphoSite	A6H8M9.
Proteomic databases
PaxDb	A6H8M9.
PRIDE	A6H8M9.
Protocols and materials databases
DNASU	389118.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343366; ENSP00000341302; ENSG00000187492. ENST00000412678; ENSP00000391409; ENSG00000187492.
GeneID	389118.
KEGG	hsa:389118.
UCSC	uc003cxp.2. human. uc010hkz.3. human.
Organism-specific databases
CTD	389118.
GeneCards	GC03M049828.
HGNC	HGNC:34527. CDHR4.
HPA	HPA043330.
neXtProt	NX_A6H8M9.
PharmGKB	PA165696944.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG74757.
HOGENOM	HOG000111287.
KO	K16504.
OMA	PPFQELT.
OrthoDB	EOG4MCX1C.
Gene expression databases
ArrayExpress	A6H8M9.
Bgee	A6H8M9.
CleanEx	HS_CDH29.
Genevestigator	A6H8M9.
Family and domain databases
Gene3D	2.60.40.60. 3 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. [Graphical view]
Pfam	PF00028. Cadherin. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 2 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 4 hits.
PROSITE	PS00232. CADHERIN_1. 1 hit. PS50268. CADHERIN_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	389118.
NextBio	102601.

Entry information

Entry name

CDHR4_HUMAN

Accession

Primary (citable) accession number: A6H8M9
Secondary accession number(s): Q6UXT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 24, 2007
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.