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Protein
Submitted name:

LIPC protein

Gene

LIPC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168NucleophileUniRule annotation1
Active sitei194Charge relay systemUniRule annotation1
Active sitei279Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

ESTHERihuman-LIPC Hepatic_Lipase

Names & Taxonomyi

Protein namesi
Submitted name:
LIPC proteinImported
Gene namesi
Name:LIPCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA230

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500269810423 – 499Sequence analysisAdd BLAST477

Proteomic databases

PeptideAtlasiA6H8L5
PRIDEiA6H8L5

Expressioni

Gene expression databases

GenevisibleiA6H8L5 HS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini352 – 493PLATInterPro annotationAdd BLAST142

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IIHP Eukaryota
ENOG4110MCZ LUCA
HOGENOMiHOG000038553
HOVERGENiHBG002259
KOiK22283

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR002333 Lipase_hep
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PTHR11610:SF2 PTHR11610:SF2, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00824 HEPLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

A6H8L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT
60 70 80 90 100
RFLLFGETNQ GCQIRINHPD TLQECGFNSS LPLVMIIHGW SVDGVLENWI
110 120 130 140 150
WQMVAALKSQ PAQPVNVGLV DWITLAHDHY TIAVRNTRLV GKEVAALLRW
160 170 180 190 200
LEESVQLSRS HVHLIGYSLG AHVSGFAGSS IGGTHKIGRI TGLDAAGPLF
210 220 230 240 250
EGSAPSNRLS PDDASFVDAI HTFTREHMGL SVGIKQPIGH YDFYPNGGSF
260 270 280 290 300
QPGCHFLELY RHIAQHGFNA ITQTIKCSHE RSVHLFIDSL LHAGTQSMAY
310 320 330 340 350
PCGDMNSFSQ GLCLSCKKGR CNTLGYHVRQ EPRSKSKRLF LVTRAQSPFK
360 370 380 390 400
VYHYQLKIQF INQTETPIQT TFTMSLLGTK EKMQKIPITL GKGIASNKTY
410 420 430 440 450
SFLITLDVDI GELIMIKFKW ENSAVWANVW DTVQTIIPWS TGPRHSGLVL
460 470 480 490
KTIRVKAGET QQRSPNRINL GRLNCSLLFC TELFSHDSLA HWSSAASEL
Length:499
Mass (Da):55,556
Last modified:July 24, 2007 - v1
Checksum:i735D9932D201C8AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146659 mRNA Translation: AAI46660.1
RefSeqiNP_000227.2, NM_000236.2
UniGeneiHs.654472

Genome annotation databases

GeneIDi3990
KEGGihsa:3990

Similar proteinsi

Entry informationi

Entry nameiA6H8L5_HUMAN
AccessioniPrimary (citable) accession number: A6H8L5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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