A6H8I0 (UBP22_DANRE) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 41.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ubiquitin carboxyl-terminal hydrolase 22 EC=3.4.19.12 Alternative name(s): Deubiquitinating enzyme 22 Ubiquitin thioesterase 22 Ubiquitin-specific-processing protease 22 | ||||
| Gene names |
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| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome] | ||||
| Taxonomic identifier | 7955 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio |
Protein attributes
| Sequence length | 506 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription By similarity. |
| Catalytic activity | Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). |
| Subunit structure | Component of some SAGA transcription coactivator-HAT complexes By similarity. |
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Belongs to the peptidase C19 family. UBP8 subfamily. Contains 1 UBP-type zinc finger. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: A6H8I0-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: A6H8I0-2) The sequence of this isoform differs from the canonical sequence as follows: 261-261: K → KG 392-506: RFEHSAKLRR...FYHKQFLEYE → VRAELLLSVLIFQHPLNVFVCFSAV | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 506 | 506 | Ubiquitin carboxyl-terminal hydrolase 22 | PRO_0000367511 | |||||
Regions | |||||||||
| Zinc finger | 44 – 104 | 61 | UBP-type | ||||||
Sites | |||||||||
| Active site | 168 | 1 | Nucleophile By similarity | ||||||
| Active site | 460 | 1 | Proton acceptor By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 261 | 1 | K → KG in isoform 2. | VSP_036726 | |||||
| Alternative sequence | 392 – 506 | 115 | RFEHS…FLEYE → VRAELLLSVLIFQHPLNVFV CFSAV in isoform 2. | VSP_036727 | |||||
Experimental info | |||||||||
| Sequence conflict | 90 | 1 | Y → H in AAI16509. Ref.1 | ||||||
Sequences
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References
| [1] | NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Embryo and Eye. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC116508 mRNA. Translation: AAI16509.1. BC146618 mRNA. Translation: AAI46619.1. |
| IPI | IPI00855315. IPI00923761. |
| RefSeq | NP_001038713.1. NM_001045248.1. |
| UniGene | Dr.87145. |
3D structure databases | |
| ProteinModelPortal | A6H8I0. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 7955.ENSDARP00000059142. |
Protein family/group databases | |
| MEROPS | C19.035. |
Proteomic databases | |
| PRIDE | A6H8I0. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 692275. |
| KEGG | dre:692275. |
Organism-specific databases | |
| CTD | 23326. |
| ZFIN | ZDB-GENE-060512-211. usp22. |
Phylogenomic databases | |
| eggNOG | COG5533. |
| HOGENOM | HOG000007260. |
| HOVERGEN | HBG058014. |
| KO | K11366. |
| OrthoDB | EOG48PMJS. |
Gene expression databases | |
| Bgee | A6H8I0. |
Family and domain databases | |
| Gene3D | 3.30.40.10. 1 hit. |
| InterPro | IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR013083. Znf_RING/FYVE/PHD. IPR001607. Znf_UBP. [Graphical view] |
| Pfam | PF00443. UCH. 1 hit. PF02148. zf-UBP. 1 hit. [Graphical view] |
| PROSITE | PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. PS50271. ZF_UBP. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 20902479. |
Entry information
| Entry name | UBP22_DANRE | ||||||||
| Accession | Primary (citable) accession number: A6H8I0 Secondary accession number(s): Q1JQ28 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |