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Reviewed, UniProtKB/Swiss-Prot A6H7I5 (DYN2_BOVIN)

Last modified October 13, 2009. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Dynamin-2
    EC=3.6.5.5
Gene names
Name: DNM2
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length866 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis By similarity.

Catalytic activity

GTP + H2O = GDP + phosphate.

Subunit structure

Interacts with MYOF, SHANK1, SHANK2, SH3BP4 and NOSTRIN By similarity.

Subcellular location

Cytoplasm By similarity. Cytoplasm › cytoskeleton By similarity. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density By similarity. Cell junction › synapse By similarity. Note: Microtubule-associated. Also found in the postsynaptic density of neuronal cells By similarity.

Sequence similarities

Belongs to the dynamin family.

Contains 1 GED domain.

Contains 1 PH domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 866866Dynamin-2
PRO_0000319950

Regions

Domain515 – 621107PH
Domain649 – 74092GED
Nucleotide binding38 – 458GTP By similarity
Nucleotide binding136 – 1405GTP By similarity
Nucleotide binding205 – 2084GTP By similarity
Compositional bias743 – 862120Pro-rich

Amino acid modifications

Modified residue2981Phosphoserine By similarity
Modified residue3021Phosphoserine By similarity
Modified residue4491Phosphotyrosine By similarity
Modified residue5931Phosphotyrosine By similarity
Modified residue5941N6-acetyllysine By similarity
Modified residue7621Phosphothreonine By similarity

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Sequences

Sequence LengthMass (Da)Tools
A6H7I5-1 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 35976F3202391BB7

FASTA86697,836
        10         20         30         40         50         60 
MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 

        70         80         90        100        110        120 
SGIVTRRPLI LQLIFSKTEY AEFLHCKSRK FTDFEEVRQE IEAETDRVTG TNKGISPVPI 

       130        140        150        160        170        180 
NLRIYSPHVL NLTLIDLPGI TKVPVGDQPQ DIEYQIKDMI LQFISRESSL ILAVTPANMD 

       190        200        210        220        230        240 
LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK 

       250        260        270        280        290        300 
DIEGKKDIRT ALAAERKFFL SHPAYRHIAD RMGTPHLQKT LNQQLTNHIR ESLPALRSKL 

       310        320        330        340        350        360 
QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ VDTLELSGGA 

       370        380        390        400        410        420 
RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT GLFTPDLAFE AIVKKQVVKL 

       430        440        450        460        470        480 
KEPCLKCVDL VIQELINTVR QCTSKLSSYP RLREETERIV TTYIREREGR TKDQILLLID 

       490        500        510        520        530        540 
IEQSYINTNH EDFIGFANAQ QRSTQLNKKR AVPNQVIRRG WLTINNISLM KGGSKEYWFV 

       550        560        570        580        590        600 
LTAESLSWYK DEEEKEKKYM LPLDNLKIRD VEKGFMSNKH VFAIFNTEQR NVYKDLRQIE 

       610        620        630        640        650        660 
LACDSQEDVD SWKASFLRAG VYPEKDQAEN EDGAQENTFS MDPQLERQVE TIRNLVDSYV 

       670        680        690        700        710        720 
AIINKSIRDL MPKTIMHLMI NNTKAFIHYE LLAYLYSSAD QSSLMEESAD QAQRRDDMLR 

       730        740        750        760        770        780 
MYHALKEALN IIGDISTSTV STPVPPPVDD TWIQNTSSHS PTPQRRPVSS VHPPGRPPAV 

       790        800        810        820        830        840 
RGPTPGPPLI PVPVGPASFS APPIPSRPGP HPGVFANNDP FSAPPQIPSR PARIPPGIPP 

       850        860 
GVPSRRPPAA PSRPTIIRPA EPSLLD

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal muscle.

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Cross-references

Sequence databases

BC146259 mRNA. Translation: AAI46260.1.
IPIIPI00716987.
RefSeqNP_001092839.1.
UniGeneBt.18482

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA6H7I5.

Genome annotation databases

EnsemblENSBTAT00000036121; ENSBTAP00000035984; ENSBTAG00000013362; Bos taurus. [Genome view]
ENSBTAT00000036123; ENSBTAP00000035986; ENSBTAG00000013362; Bos taurus. [Genome view]
GeneID511691.
KEGGbta:511691.

Organism-specific databases

CTD511691.

Enzyme and pathway databases

BRENDA3.6.5.5. 251.

Family and domain databases

InterProIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR003130. GED.
IPR001849. Pleckstrin_homology.
[Graphical view]
PfamPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSPR00195. DYNAMIN.
SMARTSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
PROSITEPS00410. DYNAMIN. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDYN2_BOVIN
AccessionPrimary (citable) accession number: A6H7I5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 24, 2007
Last modified: October 13, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents