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A6H7H7

- FBX3_BOVIN

UniProt

A6H7H7 - FBX3_BOVIN

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Protein

F-box only protein 3

Gene

FBXO3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity).By similarity

GO - Biological processi

  1. protein ubiquitination Source: InterPro
  2. proteolysis Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 3
Gene namesi
Name:FBXO3
Synonyms:FBX3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 15

Subcellular locationi

Nucleus By similarity
Note: Colocalizes with PML at the peripheries of nuclear bodies.By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469F-box only protein 3PRO_0000396823Add
BLAST

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Directly interacts with PML, either alone or within the SCF complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013287.

Structurei

3D structure databases

ProteinModelPortaliA6H7H7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 5647F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini278 – 408131ApaGPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi414 – 45037Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 apaG domain.PROSITE-ProRule annotation
Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2967.
GeneTreeiENSGT00390000009225.
HOGENOMiHOG000232174.
HOVERGENiHBG005647.
InParanoidiA6H7H7.
KOiK10290.
OMAiDLGRYIQ.
OrthoDBiEOG7GJ6CS.
TreeFamiTF329795.

Family and domain databases

Gene3Di2.60.40.1470. 1 hit.
InterProiIPR007474. ApaG_domain.
IPR001810. F-box_dom.
IPR028388. FBXO3.
IPR018958. SMI1/KNR4_like_dom.
[Graphical view]
PANTHERiPTHR14289:SF15. PTHR14289:SF15. 1 hit.
PfamiPF04379. DUF525. 1 hit.
PF12937. F-box-like. 1 hit.
PF09346. SMI1_KNR4. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00860. SMI1_KNR4. 1 hit.
[Graphical view]
SUPFAMiSSF110069. SSF110069. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51087. APAG. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6H7H7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAMDTESAP LTLESLPTDP LLLILSFLDY RDLINCCYVS RRLSQLSSHD
60 70 80 90 100
PLWRRHCKKY WLISEEEKTQ KNQCWKSLFI DTYSDVGRYI DHYAAIKKAW
110 120 130 140 150
DDLKKYLEPR CPRMVLSLKE GAREEDLDAV EAQIGCKLPD DYRCSYRIHN
160 170 180 190 200
GQKLVVPGLL GSMALSNHYR SEDLLDVDTA AGGFQQRQGL KSCLPLTFCI
210 220 230 240 250
HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI IGATFTDWFT
260 270 280 290 300
SYVNSVVSGG FPIIRDQIFR YVHDPECVAT TGDITVSVST SFLPELSSVH
310 320 330 340 350
PPHYFFTYRI RIEMSKDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG
360 370 380 390 400
EFPIISPGRV YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK IFNVAIPRFH
410 420 430 440 450
MACPTFRVSI ARLEMGPDEY EEMEEEEEEE EEEDDDDSAD MDESDDDEEE
460
RQRRVFDVPI RRRRCSRLF
Length:469
Mass (Da):54,129
Last modified:July 24, 2007 - v1
Checksum:iE6F4B59651585F1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146250 mRNA. Translation: AAI46251.1.
RefSeqiNP_001092532.1. NM_001099062.1.
UniGeneiBt.91417.

Genome annotation databases

EnsembliENSBTAT00000013287; ENSBTAP00000013287; ENSBTAG00000010071.
GeneIDi534287.
KEGGibta:534287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146250 mRNA. Translation: AAI46251.1 .
RefSeqi NP_001092532.1. NM_001099062.1.
UniGenei Bt.91417.

3D structure databases

ProteinModelPortali A6H7H7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000013287.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000013287 ; ENSBTAP00000013287 ; ENSBTAG00000010071 .
GeneIDi 534287.
KEGGi bta:534287.

Organism-specific databases

CTDi 26273.

Phylogenomic databases

eggNOGi COG2967.
GeneTreei ENSGT00390000009225.
HOGENOMi HOG000232174.
HOVERGENi HBG005647.
InParanoidi A6H7H7.
KOi K10290.
OMAi DLGRYIQ.
OrthoDBi EOG7GJ6CS.
TreeFami TF329795.

Miscellaneous databases

NextBioi 20876340.

Family and domain databases

Gene3Di 2.60.40.1470. 1 hit.
InterProi IPR007474. ApaG_domain.
IPR001810. F-box_dom.
IPR028388. FBXO3.
IPR018958. SMI1/KNR4_like_dom.
[Graphical view ]
PANTHERi PTHR14289:SF15. PTHR14289:SF15. 1 hit.
Pfami PF04379. DUF525. 1 hit.
PF12937. F-box-like. 1 hit.
PF09346. SMI1_KNR4. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
SM00860. SMI1_KNR4. 1 hit.
[Graphical view ]
SUPFAMi SSF110069. SSF110069. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEi PS51087. APAG. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thalamus.

Entry informationi

Entry nameiFBX3_BOVIN
AccessioniPrimary (citable) accession number: A6H7H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3