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Protein

F-box only protein 3

Gene

FBXO3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity).By similarity

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 3
Gene namesi
Name:FBXO3
Synonyms:FBX3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Organism-specific databases

VGNCiVGNC:28902 FBXO3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003968231 – 469F-box only protein 3Add BLAST469

Proteomic databases

PaxDbiA6H7H7

Expressioni

Gene expression databases

BgeeiENSBTAG00000010071

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Directly interacts with PML, either alone or within the SCF complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013287

Structurei

3D structure databases

ProteinModelPortaliA6H7H7
SMRiA6H7H7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 56F-boxPROSITE-ProRule annotationAdd BLAST47
Domaini278 – 408ApaGPROSITE-ProRule annotationAdd BLAST131

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi414 – 450Glu-richAdd BLAST37

Phylogenomic databases

eggNOGiKOG4408 Eukaryota
COG2967 LUCA
GeneTreeiENSGT00390000009225
HOGENOMiHOG000232174
HOVERGENiHBG005647
InParanoidiA6H7H7
KOiK10290
OMAiQRCPRMI
OrthoDBiEOG091G08GB
TreeFamiTF329795

Family and domain databases

Gene3Di2.60.40.1470, 1 hit
3.40.1580.10, 1 hit
InterProiView protein in InterPro
IPR007474 ApaG_domain
IPR036767 ApaG_sf
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR018958 Knr4/Smi1-like_dom
IPR037883 Knr4/Smi1-like_sf
PfamiView protein in Pfam
PF04379 DUF525, 1 hit
PF12937 F-box-like, 1 hit
PF09346 SMI1_KNR4, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00860 SMI1_KNR4, 1 hit
SUPFAMiSSF110069 SSF110069, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS51087 APAG, 1 hit
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

A6H7H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMDTESAP LTLESLPTDP LLLILSFLDY RDLINCCYVS RRLSQLSSHD
60 70 80 90 100
PLWRRHCKKY WLISEEEKTQ KNQCWKSLFI DTYSDVGRYI DHYAAIKKAW
110 120 130 140 150
DDLKKYLEPR CPRMVLSLKE GAREEDLDAV EAQIGCKLPD DYRCSYRIHN
160 170 180 190 200
GQKLVVPGLL GSMALSNHYR SEDLLDVDTA AGGFQQRQGL KSCLPLTFCI
210 220 230 240 250
HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI IGATFTDWFT
260 270 280 290 300
SYVNSVVSGG FPIIRDQIFR YVHDPECVAT TGDITVSVST SFLPELSSVH
310 320 330 340 350
PPHYFFTYRI RIEMSKDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG
360 370 380 390 400
EFPIISPGRV YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK IFNVAIPRFH
410 420 430 440 450
MACPTFRVSI ARLEMGPDEY EEMEEEEEEE EEEDDDDSAD MDESDDDEEE
460
RQRRVFDVPI RRRRCSRLF
Length:469
Mass (Da):54,129
Last modified:July 24, 2007 - v1
Checksum:iE6F4B59651585F1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146250 mRNA Translation: AAI46251.1
RefSeqiNP_001092532.1, NM_001099062.1
UniGeneiBt.91417

Genome annotation databases

EnsembliENSBTAT00000013287; ENSBTAP00000013287; ENSBTAG00000010071
GeneIDi534287
KEGGibta:534287

Similar proteinsi

Entry informationi

Entry nameiFBX3_BOVIN
AccessioniPrimary (citable) accession number: A6H7H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: July 24, 2007
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health