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A6H7H7

- FBX3_BOVIN

UniProt

A6H7H7 - FBX3_BOVIN

Protein

F-box only protein 3

Gene

FBXO3

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation By similarity.By similarity

    GO - Biological processi

    1. protein ubiquitination Source: InterPro
    2. proteolysis Source: InterPro

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box only protein 3
    Gene namesi
    Name:FBXO3
    Synonyms:FBX3
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 15

    Subcellular locationi

    Nucleus By similarity
    Note: Colocalizes with PML at the peripheries of nuclear bodies.By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469F-box only protein 3PRO_0000396823Add
    BLAST

    Interactioni

    Subunit structurei

    Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Directly interacts with PML, either alone or within the SCF complex By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000013287.

    Structurei

    3D structure databases

    ProteinModelPortaliA6H7H7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 5647F-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini278 – 408131ApaGPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi414 – 45037Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 apaG domain.PROSITE-ProRule annotation
    Contains 1 F-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2967.
    GeneTreeiENSGT00390000009225.
    HOGENOMiHOG000232174.
    HOVERGENiHBG005647.
    InParanoidiA6H7H7.
    KOiK10290.
    OMAiDLGRYIQ.
    OrthoDBiEOG7GJ6CS.
    TreeFamiTF329795.

    Family and domain databases

    Gene3Di2.60.40.1470. 1 hit.
    InterProiIPR007474. ApaG_domain.
    IPR001810. F-box_dom.
    IPR028388. FBXO3.
    IPR018958. SMI1/KNR4_like_dom.
    [Graphical view]
    PANTHERiPTHR14289:SF15. PTHR14289:SF15. 1 hit.
    PfamiPF04379. DUF525. 1 hit.
    PF12937. F-box-like. 1 hit.
    PF09346. SMI1_KNR4. 1 hit.
    [Graphical view]
    SMARTiSM00256. FBOX. 1 hit.
    SM00860. SMI1_KNR4. 1 hit.
    [Graphical view]
    SUPFAMiSSF110069. SSF110069. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEiPS51087. APAG. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6H7H7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAMDTESAP LTLESLPTDP LLLILSFLDY RDLINCCYVS RRLSQLSSHD    50
    PLWRRHCKKY WLISEEEKTQ KNQCWKSLFI DTYSDVGRYI DHYAAIKKAW 100
    DDLKKYLEPR CPRMVLSLKE GAREEDLDAV EAQIGCKLPD DYRCSYRIHN 150
    GQKLVVPGLL GSMALSNHYR SEDLLDVDTA AGGFQQRQGL KSCLPLTFCI 200
    HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI IGATFTDWFT 250
    SYVNSVVSGG FPIIRDQIFR YVHDPECVAT TGDITVSVST SFLPELSSVH 300
    PPHYFFTYRI RIEMSKDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG 350
    EFPIISPGRV YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK IFNVAIPRFH 400
    MACPTFRVSI ARLEMGPDEY EEMEEEEEEE EEEDDDDSAD MDESDDDEEE 450
    RQRRVFDVPI RRRRCSRLF 469
    Length:469
    Mass (Da):54,129
    Last modified:July 24, 2007 - v1
    Checksum:iE6F4B59651585F1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC146250 mRNA. Translation: AAI46251.1.
    RefSeqiNP_001092532.1. NM_001099062.1.
    UniGeneiBt.91417.

    Genome annotation databases

    EnsembliENSBTAT00000013287; ENSBTAP00000013287; ENSBTAG00000010071.
    GeneIDi534287.
    KEGGibta:534287.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC146250 mRNA. Translation: AAI46251.1 .
    RefSeqi NP_001092532.1. NM_001099062.1.
    UniGenei Bt.91417.

    3D structure databases

    ProteinModelPortali A6H7H7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000013287.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000013287 ; ENSBTAP00000013287 ; ENSBTAG00000010071 .
    GeneIDi 534287.
    KEGGi bta:534287.

    Organism-specific databases

    CTDi 26273.

    Phylogenomic databases

    eggNOGi COG2967.
    GeneTreei ENSGT00390000009225.
    HOGENOMi HOG000232174.
    HOVERGENi HBG005647.
    InParanoidi A6H7H7.
    KOi K10290.
    OMAi DLGRYIQ.
    OrthoDBi EOG7GJ6CS.
    TreeFami TF329795.

    Miscellaneous databases

    NextBioi 20876340.

    Family and domain databases

    Gene3Di 2.60.40.1470. 1 hit.
    InterProi IPR007474. ApaG_domain.
    IPR001810. F-box_dom.
    IPR028388. FBXO3.
    IPR018958. SMI1/KNR4_like_dom.
    [Graphical view ]
    PANTHERi PTHR14289:SF15. PTHR14289:SF15. 1 hit.
    Pfami PF04379. DUF525. 1 hit.
    PF12937. F-box-like. 1 hit.
    PF09346. SMI1_KNR4. 1 hit.
    [Graphical view ]
    SMARTi SM00256. FBOX. 1 hit.
    SM00860. SMI1_KNR4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110069. SSF110069. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEi PS51087. APAG. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Thalamus.

    Entry informationi

    Entry nameiFBX3_BOVIN
    AccessioniPrimary (citable) accession number: A6H7H7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3