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Protein

F-box only protein 3

Gene

FBXO3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 3
Gene namesi
Name:FBXO3
Synonyms:FBX3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 15

Subcellular locationi

  • Nucleus By similarity

  • Note: Colocalizes with PML at the peripheries of nuclear bodies.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469F-box only protein 3PRO_0000396823Add
BLAST

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Directly interacts with PML, either alone or within the SCF complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013287.

Structurei

3D structure databases

ProteinModelPortaliA6H7H7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 5647F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini278 – 408131ApaGPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi414 – 45037Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 apaG domain.PROSITE-ProRule annotation
Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2967.
GeneTreeiENSGT00390000009225.
HOGENOMiHOG000232174.
HOVERGENiHBG005647.
InParanoidiA6H7H7.
KOiK10290.
OMAiDLGRYIQ.
OrthoDBiEOG7GJ6CS.
TreeFamiTF329795.

Family and domain databases

Gene3Di2.60.40.1470. 1 hit.
InterProiIPR007474. ApaG_domain.
IPR001810. F-box_dom.
IPR028388. FBXO3.
IPR018958. SMI1/KNR4_like_dom.
[Graphical view]
PANTHERiPTHR14289:SF15. PTHR14289:SF15. 1 hit.
PfamiPF04379. DUF525. 1 hit.
PF12937. F-box-like. 1 hit.
PF09346. SMI1_KNR4. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00860. SMI1_KNR4. 1 hit.
[Graphical view]
SUPFAMiSSF110069. SSF110069. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51087. APAG. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6H7H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMDTESAP LTLESLPTDP LLLILSFLDY RDLINCCYVS RRLSQLSSHD
60 70 80 90 100
PLWRRHCKKY WLISEEEKTQ KNQCWKSLFI DTYSDVGRYI DHYAAIKKAW
110 120 130 140 150
DDLKKYLEPR CPRMVLSLKE GAREEDLDAV EAQIGCKLPD DYRCSYRIHN
160 170 180 190 200
GQKLVVPGLL GSMALSNHYR SEDLLDVDTA AGGFQQRQGL KSCLPLTFCI
210 220 230 240 250
HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI IGATFTDWFT
260 270 280 290 300
SYVNSVVSGG FPIIRDQIFR YVHDPECVAT TGDITVSVST SFLPELSSVH
310 320 330 340 350
PPHYFFTYRI RIEMSKDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG
360 370 380 390 400
EFPIISPGRV YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK IFNVAIPRFH
410 420 430 440 450
MACPTFRVSI ARLEMGPDEY EEMEEEEEEE EEEDDDDSAD MDESDDDEEE
460
RQRRVFDVPI RRRRCSRLF
Length:469
Mass (Da):54,129
Last modified:July 24, 2007 - v1
Checksum:iE6F4B59651585F1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146250 mRNA. Translation: AAI46251.1.
RefSeqiNP_001092532.1. NM_001099062.1.
UniGeneiBt.91417.

Genome annotation databases

EnsembliENSBTAT00000013287; ENSBTAP00000013287; ENSBTAG00000010071.
GeneIDi534287.
KEGGibta:534287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146250 mRNA. Translation: AAI46251.1.
RefSeqiNP_001092532.1. NM_001099062.1.
UniGeneiBt.91417.

3D structure databases

ProteinModelPortaliA6H7H7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013287.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013287; ENSBTAP00000013287; ENSBTAG00000010071.
GeneIDi534287.
KEGGibta:534287.

Organism-specific databases

CTDi26273.

Phylogenomic databases

eggNOGiCOG2967.
GeneTreeiENSGT00390000009225.
HOGENOMiHOG000232174.
HOVERGENiHBG005647.
InParanoidiA6H7H7.
KOiK10290.
OMAiDLGRYIQ.
OrthoDBiEOG7GJ6CS.
TreeFamiTF329795.

Miscellaneous databases

NextBioi20876340.

Family and domain databases

Gene3Di2.60.40.1470. 1 hit.
InterProiIPR007474. ApaG_domain.
IPR001810. F-box_dom.
IPR028388. FBXO3.
IPR018958. SMI1/KNR4_like_dom.
[Graphical view]
PANTHERiPTHR14289:SF15. PTHR14289:SF15. 1 hit.
PfamiPF04379. DUF525. 1 hit.
PF12937. F-box-like. 1 hit.
PF09346. SMI1_KNR4. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00860. SMI1_KNR4. 1 hit.
[Graphical view]
SUPFAMiSSF110069. SSF110069. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51087. APAG. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thalamus.

Entry informationi

Entry nameiFBX3_BOVIN
AccessioniPrimary (citable) accession number: A6H7H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: July 24, 2007
Last modified: May 27, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.