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A6H7H7 (FBX3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box only protein 3
Gene names
Name:FBXO3
Synonyms:FBX3
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation By similarity.

Subunit structure

Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Directly interacts with PML, either alone or within the SCF complex By similarity.

Subcellular location

Nucleus By similarity. Note: Colocalizes with PML at the peripheries of nuclear bodies By similarity.

Sequence similarities

Contains 1 apaG domain.

Contains 1 F-box domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentNucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 469469F-box only protein 3
PRO_0000396823

Regions

Domain10 – 5647F-box
Domain278 – 408131ApaG
Compositional bias414 – 45037Glu-rich

Sequences

Sequence LengthMass (Da)Tools
A6H7H7 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: E6F4B59651585F1F

FASTA46954,129
        10         20         30         40         50         60 
MAAMDTESAP LTLESLPTDP LLLILSFLDY RDLINCCYVS RRLSQLSSHD PLWRRHCKKY 

        70         80         90        100        110        120 
WLISEEEKTQ KNQCWKSLFI DTYSDVGRYI DHYAAIKKAW DDLKKYLEPR CPRMVLSLKE 

       130        140        150        160        170        180 
GAREEDLDAV EAQIGCKLPD DYRCSYRIHN GQKLVVPGLL GSMALSNHYR SEDLLDVDTA 

       190        200        210        220        230        240 
AGGFQQRQGL KSCLPLTFCI HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI 

       250        260        270        280        290        300 
IGATFTDWFT SYVNSVVSGG FPIIRDQIFR YVHDPECVAT TGDITVSVST SFLPELSSVH 

       310        320        330        340        350        360 
PPHYFFTYRI RIEMSKDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG EFPIISPGRV 

       370        380        390        400        410        420 
YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK IFNVAIPRFH MACPTFRVSI ARLEMGPDEY 

       430        440        450        460 
EEMEEEEEEE EEEDDDDSAD MDESDDDEEE RQRRVFDVPI RRRRCSRLF 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC146250 mRNA. Translation: AAI46251.1.
RefSeqNP_001092532.1. NM_001099062.1.
UniGeneBt.91417.

3D structure databases

ProteinModelPortalA6H7H7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000013287.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000013287; ENSBTAP00000013287; ENSBTAG00000010071.
GeneID534287.
KEGGbta:534287.

Organism-specific databases

CTD26273.

Phylogenomic databases

eggNOGCOG2967.
GeneTreeENSGT00390000009225.
HOGENOMHOG000232174.
HOVERGENHBG005647.
InParanoidA6H7H7.
KOK10290.
OMADLGRYIQ.
OrthoDBEOG7GJ6CS.
TreeFamTF329795.

Family and domain databases

Gene3D2.60.40.1470. 1 hit.
InterProIPR007474. ApaG_domain.
IPR001810. F-box_dom.
IPR028388. FBXO3.
IPR018958. SMI1/KNR4_like_dom.
[Graphical view]
PANTHERPTHR14289:SF15. PTHR14289:SF15. 1 hit.
PfamPF04379. DUF525. 1 hit.
PF12937. F-box-like. 1 hit.
PF09346. SMI1_KNR4. 1 hit.
[Graphical view]
SMARTSM00256. FBOX. 1 hit.
SM00860. SMI1_KNR4. 1 hit.
[Graphical view]
SUPFAMSSF110069. SSF110069. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEPS51087. APAG. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20876340.

Entry information

Entry nameFBX3_BOVIN
AccessionPrimary (citable) accession number: A6H7H7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: July 24, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families