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Protein

UDP-glucuronosyltransferase

Gene

UGT2A3

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotation, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferaseUniRule annotation (EC:2.4.1.17UniRule annotation)
Gene namesi
Name:UGT2A3Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

  • Membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei494 – 51724HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323UniRule annotationAdd
BLAST
Chaini24 – 530507UDP-glucuronosyltransferaseUniRule annotationPRO_5005121703Add
BLAST

Proteomic databases

PaxDbiA6H7H4.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051040.

Structurei

3D structure databases

ProteinModelPortaliA6H7H4.
SMRiA6H7H4. Positions 286-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6H7H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSKKWVSAI LLLQLCYTGC GFCEKVLVWP CDMSHWLNLK VILEKLMERG
60 70 80 90 100
HEVTVLVSSQ NFLIENNKPS TLNFEMFSVP QDKETAEDGL NEFLNLSVNV
110 120 130 140 150
MPTLSPWQSA KKLQDFFLQI SADLKLVCES VVYNQTIMKK LQDTNYNVMV
160 170 180 190 200
IDPVMPCGEL IAETLGIPFV YTLRLSLGST MERYCGQIPS PPSYVPVVMA
210 220 230 240 250
ALPDKMTFLQ RVKNLMFTIF FDFWLQQYDS QLWDQFYSEV LGRPTTLCET
260 270 280 290 300
MGKAEIWLIR TYWDFEFPRP YLPNFEFVGG LHCKPAKPLP KEMEEFVQSS
310 320 330 340 350
GEDGIVVFSL GSMVKNLTEE KANRIASALA QIPQKVLWRY KGKKPATLGA
360 370 380 390 400
NTRLYDWIPQ NDLLGHPKAK AFITHGGTNG IYEAIYHGVP MVGVPMFADQ
410 420 430 440 450
PDNIAHMKAK GAAVEVNINT VTSADLLNAL RTVINEPSYK ENAMRLKRIH
460 470 480 490 500
HDQPVKPLDR AVFWIEFVMR HKGAKHLRPA AHNLTWYQYH SLDVIGFLLA
510 520 530
CVATAVFLVT RCCLFSCRKF GKTGKKKKRE
Length:530
Mass (Da):60,405
Last modified:July 24, 2007 - v1
Checksum:i01AEA620C60DDD35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146247 mRNA. Translation: AAI46248.1.
RefSeqiNP_001092414.1. NM_001098944.1.
UniGeneiBt.42075.

Genome annotation databases

GeneIDi511743.
KEGGibta:511743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146247 mRNA. Translation: AAI46248.1.
RefSeqiNP_001092414.1. NM_001098944.1.
UniGeneiBt.42075.

3D structure databases

ProteinModelPortaliA6H7H4.
SMRiA6H7H4. Positions 286-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051040.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbiA6H7H4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi511743.
KEGGibta:511743.

Organism-specific databases

CTDi10941.

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
KOiK00699.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA6H7H4_BOVIN
AccessioniPrimary (citable) accession number: A6H7H4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: July 6, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.