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A6H779

- FBXL2_BOVIN

UniProt

A6H779 - FBXL2_BOVIN

Protein

F-box/LRR-repeat protein 2

Gene

FBXL2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin. Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G0, also antagonized by calmodulin By similarity.By similarity

    GO - Molecular functioni

    1. ubiquitin-protein transferase activity Source: Ensembl

    GO - Biological processi

    1. protein monoubiquitination Source: Ensembl
    2. ubiquitin-dependent protein catabolic process Source: Ensembl

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Calcium, Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box/LRR-repeat protein 2
    Alternative name(s):
    F-box and leucine-rich repeat protein 2
    Gene namesi
    Name:FBXL2
    Synonyms:FBL2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 22

    Subcellular locationi

    Membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423F-box/LRR-repeat protein 2PRO_0000354084Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi420 – 4201S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Prenylation

    Interactioni

    Subunit structurei

    Interacts with SKP1. Interacts with PCYT1A. Interacts with CCND2 and CCND3. Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000005160.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 5547F-boxPROSITE-ProRule annotationAdd
    BLAST
    Repeati61 – 8727LRR 1Add
    BLAST
    Repeati88 – 11326LRR 2Add
    BLAST
    Repeati114 – 13926LRR 3Add
    BLAST
    Repeati140 – 16526LRR 4Add
    BLAST
    Repeati166 – 19126LRR 5Add
    BLAST
    Repeati192 – 21726LRR 6Add
    BLAST
    Repeati218 – 24326LRR 7Add
    BLAST
    Repeati244 – 26926LRR 8Add
    BLAST
    Repeati270 – 29526LRR 9Add
    BLAST
    Repeati296 – 32126LRR 10Add
    BLAST
    Repeati322 – 35029LRR 11Add
    BLAST
    Repeati351 – 37525LRR 12Add
    BLAST
    Repeati376 – 40126LRR 13Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni80 – 9011Interaction with CalmodulinBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi420 – 4234CAAX motif

    Sequence similaritiesi

    Contains 1 F-box domain.PROSITE-ProRule annotation
    Contains 13 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG300245.
    GeneTreeiENSGT00750000117496.
    HOGENOMiHOG000230659.
    HOVERGENiHBG051586.
    InParanoidiA6H779.
    KOiK10268.
    OMAiCVAITNS.
    OrthoDBiEOG7CVPXM.
    TreeFamiTF313434.

    Family and domain databases

    InterProiIPR001810. F-box_dom.
    IPR006553. Leu-rich_rpt_Cys-con_subtyp.
    [Graphical view]
    PfamiPF12937. F-box-like. 1 hit.
    [Graphical view]
    SMARTiSM00256. FBOX. 1 hit.
    SM00367. LRR_CC. 2 hits.
    [Graphical view]
    PROSITEiPS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6H779-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVFSNNDEGL INKKLPKELL LRIFSFLDIV TLCRCAQISK AWNILALDGS    50
    NWQRIDLFNF QTDVEGRVVE NISKRCGGFL RKLSLRGCIG VGDSSLKTFA 100
    QNCRNIEHLN LNGCTKITDS TCYSLSRFCS KLKHLDLTSC VSITNSSLKG 150
    ISEGCRHLEY LNLSWCDQIT KDGVEALVRG CRGLRALLLR GCTQLEDEAL 200
    KHIQNYCHEL VSLNLQSCSR VTDDGVVQLC RGCPRLQALC LSGCGSLTDA 250
    SLTALALNCP RLQILEAARC SHLTDAGFTL LARNCHDLEK MDLEECILIT 300
    DRTLTQLSIH CPKLQALSLS HCELITDDGI LHLSNSPCGH ERLRVLELDN 350
    CLLITDVALE HLEHCRGLER LELYDCQQVT RAGIKRMRAQ LPHVRVHAYF 400
    APVTPPTAAG GGGPRLCRCC VIL 423
    Length:423
    Mass (Da):46,975
    Last modified:July 24, 2007 - v1
    Checksum:i6850504C474C7CE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC146145 mRNA. Translation: AAI46146.1.
    RefSeqiNP_001092623.1. NM_001099153.2.
    UniGeneiBt.54599.

    Genome annotation databases

    EnsembliENSBTAT00000005160; ENSBTAP00000005160; ENSBTAG00000003952.
    GeneIDi616212.
    KEGGibta:616212.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC146145 mRNA. Translation: AAI46146.1 .
    RefSeqi NP_001092623.1. NM_001099153.2.
    UniGenei Bt.54599.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000005160.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000005160 ; ENSBTAP00000005160 ; ENSBTAG00000003952 .
    GeneIDi 616212.
    KEGGi bta:616212.

    Organism-specific databases

    CTDi 25827.

    Phylogenomic databases

    eggNOGi NOG300245.
    GeneTreei ENSGT00750000117496.
    HOGENOMi HOG000230659.
    HOVERGENi HBG051586.
    InParanoidi A6H779.
    KOi K10268.
    OMAi CVAITNS.
    OrthoDBi EOG7CVPXM.
    TreeFami TF313434.

    Miscellaneous databases

    NextBioi 20900019.

    Family and domain databases

    InterProi IPR001810. F-box_dom.
    IPR006553. Leu-rich_rpt_Cys-con_subtyp.
    [Graphical view ]
    Pfami PF12937. F-box-like. 1 hit.
    [Graphical view ]
    SMARTi SM00256. FBOX. 1 hit.
    SM00367. LRR_CC. 2 hits.
    [Graphical view ]
    PROSITEi PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal pons.

    Entry informationi

    Entry nameiFBXL2_BOVIN
    AccessioniPrimary (citable) accession number: A6H779
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3