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A6H779

- FBXL2_BOVIN

UniProt

A6H779 - FBXL2_BOVIN

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Protein

F-box/LRR-repeat protein 2

Gene
FBXL2, FBL2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin. Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G0, also antagonized by calmodulin By similarity.

GO - Molecular functioni

  1. ubiquitin-protein transferase activity Source: Ensembl

GO - Biological processi

  1. protein monoubiquitination Source: Ensembl
  2. ubiquitin-dependent protein catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Calcium, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 2
Alternative name(s):
F-box and leucine-rich repeat protein 2
Gene namesi
Name:FBXL2
Synonyms:FBL2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 22

Subcellular locationi

Membrane; Lipid-anchor By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423F-box/LRR-repeat protein 2PRO_0000354084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi420 – 4201S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Prenylation

Interactioni

Subunit structurei

Interacts with SKP1. Interacts with PCYT1A. Interacts with CCND2 and CCND3. Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005160.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 5547F-boxAdd
BLAST
Repeati61 – 8727LRR 1Add
BLAST
Repeati88 – 11326LRR 2Add
BLAST
Repeati114 – 13926LRR 3Add
BLAST
Repeati140 – 16526LRR 4Add
BLAST
Repeati166 – 19126LRR 5Add
BLAST
Repeati192 – 21726LRR 6Add
BLAST
Repeati218 – 24326LRR 7Add
BLAST
Repeati244 – 26926LRR 8Add
BLAST
Repeati270 – 29526LRR 9Add
BLAST
Repeati296 – 32126LRR 10Add
BLAST
Repeati322 – 35029LRR 11Add
BLAST
Repeati351 – 37525LRR 12Add
BLAST
Repeati376 – 40126LRR 13Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni80 – 9011Interaction with Calmodulin By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi420 – 4234CAAX motif

Sequence similaritiesi

Contains 1 F-box domain.

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG300245.
GeneTreeiENSGT00750000117496.
HOGENOMiHOG000230659.
HOVERGENiHBG051586.
InParanoidiA6H779.
KOiK10268.
OMAiCVAITNS.
OrthoDBiEOG7CVPXM.
TreeFamiTF313434.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 2 hits.
[Graphical view]
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6H779-1 [UniParc]FASTAAdd to Basket

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MVFSNNDEGL INKKLPKELL LRIFSFLDIV TLCRCAQISK AWNILALDGS    50
NWQRIDLFNF QTDVEGRVVE NISKRCGGFL RKLSLRGCIG VGDSSLKTFA 100
QNCRNIEHLN LNGCTKITDS TCYSLSRFCS KLKHLDLTSC VSITNSSLKG 150
ISEGCRHLEY LNLSWCDQIT KDGVEALVRG CRGLRALLLR GCTQLEDEAL 200
KHIQNYCHEL VSLNLQSCSR VTDDGVVQLC RGCPRLQALC LSGCGSLTDA 250
SLTALALNCP RLQILEAARC SHLTDAGFTL LARNCHDLEK MDLEECILIT 300
DRTLTQLSIH CPKLQALSLS HCELITDDGI LHLSNSPCGH ERLRVLELDN 350
CLLITDVALE HLEHCRGLER LELYDCQQVT RAGIKRMRAQ LPHVRVHAYF 400
APVTPPTAAG GGGPRLCRCC VIL 423
Length:423
Mass (Da):46,975
Last modified:July 24, 2007 - v1
Checksum:i6850504C474C7CE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC146145 mRNA. Translation: AAI46146.1.
RefSeqiNP_001092623.1. NM_001099153.2.
UniGeneiBt.54599.

Genome annotation databases

EnsembliENSBTAT00000005160; ENSBTAP00000005160; ENSBTAG00000003952.
GeneIDi616212.
KEGGibta:616212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC146145 mRNA. Translation: AAI46146.1 .
RefSeqi NP_001092623.1. NM_001099153.2.
UniGenei Bt.54599.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000005160.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000005160 ; ENSBTAP00000005160 ; ENSBTAG00000003952 .
GeneIDi 616212.
KEGGi bta:616212.

Organism-specific databases

CTDi 25827.

Phylogenomic databases

eggNOGi NOG300245.
GeneTreei ENSGT00750000117496.
HOGENOMi HOG000230659.
HOVERGENi HBG051586.
InParanoidi A6H779.
KOi K10268.
OMAi CVAITNS.
OrthoDBi EOG7CVPXM.
TreeFami TF313434.

Miscellaneous databases

NextBioi 20900019.

Family and domain databases

InterProi IPR001810. F-box_dom.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view ]
Pfami PF12937. F-box-like. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
SM00367. LRR_CC. 2 hits.
[Graphical view ]
PROSITEi PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons.

Entry informationi

Entry nameiFBXL2_BOVIN
AccessioniPrimary (citable) accession number: A6H779
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 24, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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