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A6H779 (FBXL2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box/LRR-repeat protein 2
Alternative name(s):
F-box and leucine-rich repeat protein 2
Gene names
Name:FBXL2
Synonyms:FBL2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin. Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G0, also antagonized by calmodulin By similarity.

Subunit structure

Interacts with SKP1. Interacts with PCYT1A. Interacts with CCND2 and CCND3. Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity.

Subcellular location

Membrane; Lipid-anchor By similarity.

Sequence similarities

Contains 1 F-box domain.

Contains 13 LRR (leucine-rich) repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423F-box/LRR-repeat protein 2
PRO_0000354084

Regions

Domain9 – 5547F-box
Repeat61 – 8727LRR 1
Repeat88 – 11326LRR 2
Repeat114 – 13926LRR 3
Repeat140 – 16526LRR 4
Repeat166 – 19126LRR 5
Repeat192 – 21726LRR 6
Repeat218 – 24326LRR 7
Repeat244 – 26926LRR 8
Repeat270 – 29526LRR 9
Repeat296 – 32126LRR 10
Repeat322 – 35029LRR 11
Repeat351 – 37525LRR 12
Repeat376 – 40126LRR 13
Region80 – 9011Interaction with Calmodulin By similarity
Motif420 – 4234CAAX motif

Amino acid modifications

Lipidation4201S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
A6H779 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 6850504C474C7CE7

FASTA42346,975
        10         20         30         40         50         60 
MVFSNNDEGL INKKLPKELL LRIFSFLDIV TLCRCAQISK AWNILALDGS NWQRIDLFNF 

        70         80         90        100        110        120 
QTDVEGRVVE NISKRCGGFL RKLSLRGCIG VGDSSLKTFA QNCRNIEHLN LNGCTKITDS 

       130        140        150        160        170        180 
TCYSLSRFCS KLKHLDLTSC VSITNSSLKG ISEGCRHLEY LNLSWCDQIT KDGVEALVRG 

       190        200        210        220        230        240 
CRGLRALLLR GCTQLEDEAL KHIQNYCHEL VSLNLQSCSR VTDDGVVQLC RGCPRLQALC 

       250        260        270        280        290        300 
LSGCGSLTDA SLTALALNCP RLQILEAARC SHLTDAGFTL LARNCHDLEK MDLEECILIT 

       310        320        330        340        350        360 
DRTLTQLSIH CPKLQALSLS HCELITDDGI LHLSNSPCGH ERLRVLELDN CLLITDVALE 

       370        380        390        400        410        420 
HLEHCRGLER LELYDCQQVT RAGIKRMRAQ LPHVRVHAYF APVTPPTAAG GGGPRLCRCC 


VIL 

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal pons.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC146145 mRNA. Translation: AAI46146.1.
RefSeqNP_001092623.1. NM_001099153.2.
UniGeneBt.54599.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000005160.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000005160; ENSBTAP00000005160; ENSBTAG00000003952.
GeneID616212.
KEGGbta:616212.

Organism-specific databases

CTD25827.

Phylogenomic databases

eggNOGNOG300245.
GeneTreeENSGT00750000117496.
HOGENOMHOG000230659.
HOVERGENHBG051586.
InParanoidA6H779.
KOK10268.
OMAHSCETIS.
OrthoDBEOG7CVPXM.
TreeFamTF313434.

Family and domain databases

InterProIPR001810. F-box_dom.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
SMARTSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 2 hits.
[Graphical view]
PROSITEPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20900019.

Entry information

Entry nameFBXL2_BOVIN
AccessionPrimary (citable) accession number: A6H779
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families