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Protein

Lysophosphatidic acid phosphatase type 6

Gene

ACP6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.1 Publication

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei59 – 591NucleophileBy similarity
Active sitei336 – 3361Proton donorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid phosphatase type 6 (EC:3.1.3.2)
Gene namesi
Name:ACP6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componentsi: Chromosome 3, Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3232MitochondrionBy similarityAdd
BLAST
Chaini33 – 429397Lysophosphatidic acid phosphatase type 6By similarityPRO_0000424239Add
BLAST

Proteomic databases

PaxDbiA6H757.

Expressioni

Tissue specificityi

Detected in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSBTAG00000017051.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022675.

Structurei

3D structure databases

ProteinModelPortaliA6H757.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 169112Substrate bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3720. Eukaryota.
ENOG410ZVBQ. LUCA.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000290692.
HOVERGENiHBG079458.
InParanoidiA6H757.
KOiK14395.
OMAiSKEWFVQ.
OrthoDBiEOG091G05TQ.
TreeFamiTF318821.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 2 hits.
InterProiIPR033379. Acid_Pase_AS.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 2 hits.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6H757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISRVFKLRM WAPVGVLTSL TYCLHQRRVA LAEPGGADQQ NPVDRNLLEL
60 70 80 90 100
KMVQVVFRHG ARSPLKPLPQ EDQQVEWKSQ LLEVPPQTQL EYTVTNLAGG
110 120 130 140 150
PKPHSPFDSQ YHETTLKGGM FAGQLTKVGM EQMFALGERL RKNYVEDIPF
160 170 180 190 200
LSPTFNPLEV FIRSTNIYRN LESTRCLLAG LFQRQKEGPI VIHTDEASSE
210 220 230 240 250
VLYPNYQYCW NLQKRTRGRR QAASLQPGIS EDLKKVKEGM GIASSDEVDF
260 270 280 290 300
LVLLDNMAAE QVHSLPSCPT LKRFAWMIEQ RAVDTALYIL QWEDREGLQM
310 320 330 340 350
AVGPFLHILE SNLLKVVDPA TPPSKTRKLY LYAAHDVTLM PLLMTLGIFD
360 370 380 390 400
HKWPPFAVDL TMELYQHRES KEWFVQLYYR GKEQVPKGCP DGLCPLDKFL
410 420
NTISVYTLSP EKYHMLCSEA QMMGLGNGE
Length:429
Mass (Da):48,945
Last modified:July 24, 2007 - v1
Checksum:iBB1C199EE3661CA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02007328 Genomic DNA. No translation available.
BC146121 mRNA. Translation: AAI46122.1.
RefSeqiNP_001092843.1. NM_001099373.2.
UniGeneiBt.9014.

Genome annotation databases

EnsembliENSBTAT00000022675; ENSBTAP00000022675; ENSBTAG00000017051.
GeneIDi515738.
KEGGibta:515738.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02007328 Genomic DNA. No translation available.
BC146121 mRNA. Translation: AAI46122.1.
RefSeqiNP_001092843.1. NM_001099373.2.
UniGeneiBt.9014.

3D structure databases

ProteinModelPortaliA6H757.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022675.

Proteomic databases

PaxDbiA6H757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022675; ENSBTAP00000022675; ENSBTAG00000017051.
GeneIDi515738.
KEGGibta:515738.

Organism-specific databases

CTDi51205.

Phylogenomic databases

eggNOGiKOG3720. Eukaryota.
ENOG410ZVBQ. LUCA.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000290692.
HOVERGENiHBG079458.
InParanoidiA6H757.
KOiK14395.
OMAiSKEWFVQ.
OrthoDBiEOG091G05TQ.
TreeFamiTF318821.

Gene expression databases

BgeeiENSBTAG00000017051.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 2 hits.
InterProiIPR033379. Acid_Pase_AS.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 2 hits.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPA6_BOVIN
AccessioniPrimary (citable) accession number: A6H757
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2013
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.