Reviewed, UniProtKB/Swiss-Prot A6H730 (PPAP_BOVIN)

Names and origin

Protein names

Recommended name:
    Prostatic acid phosphatase
    EC=3.1.3.2

Gene names

Name:

ACPP

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A phosphate monoester + H2O = an alcohol + phosphate.
Subunit structure	Homodimer By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acid phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34	Potential
	Chain	35 – 387	353	Prostatic acid phosphatase		PRO_0000356292
Sites
	Active site	46	1	Nucleophile By similarity
	Active site	292	1	Proton donor By similarity
Amino acid modifications
	Glycosylation	96	1	N-linked (GlcNAc...) Potential
	Glycosylation	222	1	N-linked (GlcNAc...) Potential
	Glycosylation	335	1	N-linked (GlcNAc...) Potential
	Disulfide bond	163 ↔ 374		By similarity
	Disulfide bond	217 ↔ 315		By similarity
	Disulfide bond	349 ↔ 353		By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6H730-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 67241408CDEC7907	FASTA	387	44,622
	10 20 30 40 50 60 MRNAALLMTR ATSLRLSLLL LLSFLPDLDG GVRAKELRFV TLVFRHGDRS PIETFPNDPI 70 80 90 100 110 120 KESSWPQGFG QLTQLGMAQH YELGQYIRKR YENFLNESYK REQVHVRSTD IDRTLMSAMT 130 140 150 160 170 180 NLAALFPPEG ISIWNPSLPW QPIPVHTVPV SEDQLLYLPF RNCPRFQELQ SETLISEEFQ 190 200 210 220 230 240 KRLQPYKDFI EVLPKLTGYH DQDLLGIWSK VYDPLFCEGV HNFTLPSWAT EDTMTKLKEI 250 260 270 280 290 300 SELSLLSLYG IHKQKEKSRL QGGVLINEIL NHMKSATQPS NRRKLIMYSA HDTTVSGLQM 310 320 330 340 350 360 ALDVYNGILP PYASCHMMEL YFQDGEYFVE MYYRNETRYE PHPLTLPGCT PSCPLAKFVE 370 380 LVAPVISQDW SMECAIRNHK GTEDIIN

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal skin.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC146093 mRNA. Translation: AAI46094.1.
IPI	IPI00707272.
RefSeq	NP_001092336.1.
UniGene	Bt.61011
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000015451; ENSBTAP00000015451; ENSBTAG00000011634; Bos taurus. [Genome view]
GeneID	504700.
KEGG	bta:504700.
Organism-specific databases
CTD	504700.
Phylogenomic databases
OMA	VHNFTLP.
Family and domain databases
InterPro	IPR000560. Histidine_acid_Pase. [Graphical view]
Pfam	PF00328. Acid_phosphat_A. 1 hit. [Graphical view]
PROSITE	PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPAP_BOVIN

Accession

Primary (citable) accession number: A6H730

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	July 24, 2007
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)