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Protein

Prostatic acid phosphatase

Gene

ACPP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity).By similarity

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451SubstrateBy similarity
Active sitei46 – 461NucleophileBy similarity
Binding sitei49 – 491SubstrateBy similarity
Sitei51 – 511Important for substrate specificityBy similarity
Binding sitei113 – 1131SubstrateBy similarity
Sitei208 – 2081Required for structural stabilityBy similarity
Binding sitei291 – 2911SubstrateBy similarity
Active sitei292 – 2921Proton donorCurated

GO - Molecular functioni

  1. 5'-nucleotidase activity Source: UniProtKB
  2. acid phosphatase activity Source: UniProtKB
  3. lysophosphatidic acid phosphatase activity Source: UniProtKB
  4. phosphatase activity Source: UniProtKB
  5. thiamine phosphate phosphatase activity Source: UniProtKB

GO - Biological processi

  1. adenosine metabolic process Source: UniProtKB
  2. dephosphorylation Source: UniProtKB
  3. nucleotide metabolic process Source: Ensembl
  4. positive regulation of adenosine receptor signaling pathway Source: UniProtKB
  5. purine nucleobase metabolic process Source: Ensembl
  6. regulation of sensory perception of pain Source: UniProtKB
  7. thiamine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Prostatic acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:ACPP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 1

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
  2. extracellular vesicular exosome Source: Ensembl
  3. filopodium Source: Ensembl
  4. integral component of membrane Source: Ensembl
  5. lysosomal membrane Source: Ensembl
  6. nucleus Source: Ensembl
  7. plasma membrane Source: UniProtKB
  8. vesicle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 387353Prostatic acid phosphatasePRO_0000356292Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi163 ↔ 374By similarity
Disulfide bondi217 ↔ 315By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi349 ↔ 353By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer; dimer formation is required for phosphatase activity.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015451.

Structurei

3D structure databases

ProteinModelPortaliA6H730.
SMRiA6H730. Positions 35-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG85977.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000231439.
HOVERGENiHBG002203.
InParanoidiA6H730.
KOiK14410.
OMAiFTLPSWA.
OrthoDBiEOG7GXPBJ.
TreeFamiTF312893.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6H730-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRNAALLMTR ATSLRLSLLL LLSFLPDLDG GVRAKELRFV TLVFRHGDRS
60 70 80 90 100
PIETFPNDPI KESSWPQGFG QLTQLGMAQH YELGQYIRKR YENFLNESYK
110 120 130 140 150
REQVHVRSTD IDRTLMSAMT NLAALFPPEG ISIWNPSLPW QPIPVHTVPV
160 170 180 190 200
SEDQLLYLPF RNCPRFQELQ SETLISEEFQ KRLQPYKDFI EVLPKLTGYH
210 220 230 240 250
DQDLLGIWSK VYDPLFCEGV HNFTLPSWAT EDTMTKLKEI SELSLLSLYG
260 270 280 290 300
IHKQKEKSRL QGGVLINEIL NHMKSATQPS NRRKLIMYSA HDTTVSGLQM
310 320 330 340 350
ALDVYNGILP PYASCHMMEL YFQDGEYFVE MYYRNETRYE PHPLTLPGCT
360 370 380
PSCPLAKFVE LVAPVISQDW SMECAIRNHK GTEDIIN
Length:387
Mass (Da):44,622
Last modified:July 24, 2007 - v1
Checksum:i67241408CDEC7907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146093 mRNA. Translation: AAI46094.1.
RefSeqiNP_001092336.1. NM_001098866.1.
UniGeneiBt.61011.

Genome annotation databases

EnsembliENSBTAT00000015451; ENSBTAP00000015451; ENSBTAG00000011634.
GeneIDi504700.
KEGGibta:504700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146093 mRNA. Translation: AAI46094.1.
RefSeqiNP_001092336.1. NM_001098866.1.
UniGeneiBt.61011.

3D structure databases

ProteinModelPortaliA6H730.
SMRiA6H730. Positions 35-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015451.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000015451; ENSBTAP00000015451; ENSBTAG00000011634.
GeneIDi504700.
KEGGibta:504700.

Organism-specific databases

CTDi55.

Phylogenomic databases

eggNOGiNOG85977.
GeneTreeiENSGT00530000062956.
HOGENOMiHOG000231439.
HOVERGENiHBG002203.
InParanoidiA6H730.
KOiK14410.
OMAiFTLPSWA.
OrthoDBiEOG7GXPBJ.
TreeFamiTF312893.

Miscellaneous databases

NextBioi20866790.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.

Entry informationi

Entry nameiPPAP_BOVIN
AccessioniPrimary (citable) accession number: A6H730
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 24, 2007
Last modified: January 7, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.