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A6H730

- PPAP_BOVIN

UniProt

A6H730 - PPAP_BOVIN

Protein

Prostatic acid phosphatase

Gene

ACPP

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma By similarity.By similarity

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei45 – 451SubstrateBy similarity
    Active sitei46 – 461NucleophileBy similarity
    Binding sitei49 – 491SubstrateBy similarity
    Sitei51 – 511Important for substrate specificityBy similarity
    Binding sitei113 – 1131SubstrateBy similarity
    Sitei208 – 2081Required for structural stabilityBy similarity
    Binding sitei291 – 2911SubstrateBy similarity
    Active sitei292 – 2921Proton donorCurated

    GO - Molecular functioni

    1. 5'-nucleotidase activity Source: UniProt
    2. acid phosphatase activity Source: UniProt
    3. lysophosphatidic acid phosphatase activity Source: UniProt
    4. phosphatase activity Source: UniProt
    5. thiamine phosphate phosphatase activity Source: UniProt

    GO - Biological processi

    1. adenosine metabolic process Source: UniProt
    2. dephosphorylation Source: UniProt
    3. nucleotide metabolic process Source: Ensembl
    4. positive regulation of adenosine receptor signaling pathway Source: UniProt
    5. purine nucleobase metabolic process Source: Ensembl
    6. regulation of sensory perception of pain Source: UniProt
    7. thiamine metabolic process Source: UniProt

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostatic acid phosphatase (EC:3.1.3.2)
    Gene namesi
    Name:ACPP
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 1

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. filopodium Source: Ensembl
    3. integral component of membrane Source: Ensembl
    4. lysosomal membrane Source: Ensembl
    5. plasma membrane Source: UniProt
    6. vesicle membrane Source: UniProt

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 387353Prostatic acid phosphatasePRO_0000356292Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi163 ↔ 374By similarity
    Disulfide bondi217 ↔ 315By similarity
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi349 ↔ 353By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer; dimer formation is required for phosphatase activity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000015451.

    Structurei

    3D structure databases

    ProteinModelPortaliA6H730.
    SMRiA6H730. Positions 35-374.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG85977.
    GeneTreeiENSGT00530000062956.
    HOGENOMiHOG000231439.
    HOVERGENiHBG002203.
    InParanoidiA6H730.
    KOiK14410.
    OMAiFTLPSWA.
    OrthoDBiEOG7GXPBJ.
    TreeFamiTF312893.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A6H730-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRNAALLMTR ATSLRLSLLL LLSFLPDLDG GVRAKELRFV TLVFRHGDRS    50
    PIETFPNDPI KESSWPQGFG QLTQLGMAQH YELGQYIRKR YENFLNESYK 100
    REQVHVRSTD IDRTLMSAMT NLAALFPPEG ISIWNPSLPW QPIPVHTVPV 150
    SEDQLLYLPF RNCPRFQELQ SETLISEEFQ KRLQPYKDFI EVLPKLTGYH 200
    DQDLLGIWSK VYDPLFCEGV HNFTLPSWAT EDTMTKLKEI SELSLLSLYG 250
    IHKQKEKSRL QGGVLINEIL NHMKSATQPS NRRKLIMYSA HDTTVSGLQM 300
    ALDVYNGILP PYASCHMMEL YFQDGEYFVE MYYRNETRYE PHPLTLPGCT 350
    PSCPLAKFVE LVAPVISQDW SMECAIRNHK GTEDIIN 387
    Length:387
    Mass (Da):44,622
    Last modified:July 24, 2007 - v1
    Checksum:i67241408CDEC7907
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC146093 mRNA. Translation: AAI46094.1.
    RefSeqiNP_001092336.1. NM_001098866.1.
    UniGeneiBt.61011.

    Genome annotation databases

    EnsembliENSBTAT00000015451; ENSBTAP00000015451; ENSBTAG00000011634.
    GeneIDi504700.
    KEGGibta:504700.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC146093 mRNA. Translation: AAI46094.1 .
    RefSeqi NP_001092336.1. NM_001098866.1.
    UniGenei Bt.61011.

    3D structure databases

    ProteinModelPortali A6H730.
    SMRi A6H730. Positions 35-374.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000015451.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000015451 ; ENSBTAP00000015451 ; ENSBTAG00000011634 .
    GeneIDi 504700.
    KEGGi bta:504700.

    Organism-specific databases

    CTDi 55.

    Phylogenomic databases

    eggNOGi NOG85977.
    GeneTreei ENSGT00530000062956.
    HOGENOMi HOG000231439.
    HOVERGENi HBG002203.
    InParanoidi A6H730.
    KOi K14410.
    OMAi FTLPSWA.
    OrthoDBi EOG7GXPBJ.
    TreeFami TF312893.

    Miscellaneous databases

    NextBioi 20866790.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal skin.

    Entry informationi

    Entry nameiPPAP_BOVIN
    AccessioniPrimary (citable) accession number: A6H730
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3