A6H730 (PPAP_BOVIN) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 36.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Prostatic acid phosphatase EC=3.1.3.2 | ||
| Gene names |
| ||
| Organism | Bos taurus (Bovine) [Reference proteome] | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos![]() |
Protein attributes
| Sequence length | 387 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma By similarity. |
| Catalytic activity | A phosphate monoester + H2O = an alcohol + phosphate. |
| Subunit structure | Homodimer; dimer formation is required for phosphatase activity By similarity. |
| Subcellular location | Secreted By similarity. |
| Sequence similarities | Belongs to the histidine acid phosphatase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Hydrolase |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | adenosine metabolic process Inferred from electronic annotation. Source: Compara nucleotide metabolic processInferred from electronic annotation. Source: Compara purine nucleobase metabolic processInferred from electronic annotation. Source: Compara |
| Cellular_component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell filopodiumInferred from electronic annotation. Source: Compara integral to membraneInferred from electronic annotation. Source: Compara intracellularInferred from electronic annotation. Source: Compara plasma membraneInferred from electronic annotation. Source: Compara |
| Molecular_function | acid phosphatase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 34 | 34 | Potential | ||||||||
| Chain | 35 – 387 | 353 | Prostatic acid phosphatase | PRO_0000356292 | |||||||
Sites | |||||||||||
| Active site | 46 | 1 | Nucleophile By similarity | ||||||||
| Active site | 292 | 1 | Proton donor Probable | ||||||||
| Binding site | 45 | 1 | Substrate By similarity | ||||||||
| Binding site | 49 | 1 | Substrate By similarity | ||||||||
| Binding site | 113 | 1 | Substrate By similarity | ||||||||
| Binding site | 291 | 1 | Substrate By similarity | ||||||||
| Site | 51 | 1 | Important for substrate specificity By similarity | ||||||||
| Site | 208 | 1 | Required for structural stability By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 96 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 222 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 335 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 163 ↔ 374 | By similarity | |||||||||
| Disulfide bond | 217 ↔ 315 | By similarity | |||||||||
| Disulfide bond | 349 ↔ 353 | By similarity | |||||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal skin. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC146093 mRNA. Translation: AAI46094.1. |
| IPI | IPI00707272. |
| RefSeq | NP_001092336.1. NM_001098866.1. |
| UniGene | Bt.61011. |
3D structure databases | |
| ProteinModelPortal | A6H730. |
| SMR | A6H730. Positions 35-374. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 9913.ENSBTAP00000015451. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAT00000015451; ENSBTAP00000015451; ENSBTAG00000011634. |
| GeneID | 504700. |
| KEGG | bta:504700. |
Organism-specific databases | |
| CTD | 55. |
Phylogenomic databases | |
| eggNOG | NOG85977. |
| GeneTree | ENSGT00530000062956. |
| HOGENOM | HOG000231439. |
| HOVERGEN | HBG002203. |
| InParanoid | A6H730. |
| KO | K14410. |
| OMA | FTLPSWA. |
| OrthoDB | EOG4NKBVM. |
Family and domain databases | |
| InterPro | IPR000560. His_Pase_superF_clade-2. [Graphical view] |
| Pfam | PF00328. His_Phos_2. 1 hit. [Graphical view] |
| PROSITE | PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 20866790. |
Entry information
| Entry name | PPAP_BOVIN | ||||||||
| Accession | Primary (citable) accession number: A6H730 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
