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Protein

Prostatic acid phosphatase

Gene

ACPP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity).By similarity

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45SubstrateBy similarity1
Active sitei46NucleophileBy similarity1
Binding sitei49SubstrateBy similarity1
Sitei51Important for substrate specificityBy similarity1
Binding sitei113SubstrateBy similarity1
Sitei208Required for structural stabilityBy similarity1
Binding sitei291SubstrateBy similarity1
Active sitei292Proton donorCurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-BTA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Prostatic acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:ACPP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:52603 ACPP

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000035629235 – 387Prostatic acid phosphataseAdd BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi163 ↔ 374By similarity
Disulfide bondi217 ↔ 315By similarity
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi335N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi349 ↔ 353By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6H730
PRIDEiA6H730

Expressioni

Gene expression databases

BgeeiENSBTAG00000011634

Interactioni

Subunit structurei

Homodimer; dimer formation is required for phosphatase activity.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015451

Structurei

3D structure databases

ProteinModelPortaliA6H730
SMRiA6H730
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3720 Eukaryota
ENOG410ZVBQ LUCA
GeneTreeiENSGT00530000062956
HOGENOMiHOG000231439
HOVERGENiHBG002203
InParanoidiA6H730
KOiK19283
OMAiYGIHKQK
OrthoDBiEOG091G09FA
TreeFamiTF312893

Family and domain databases

CDDicd07061 HP_HAP_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR029033 His_PPase_superfam
PfamiView protein in Pfam
PF00328 His_Phos_2, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit
PS00778 HIS_ACID_PHOSPHAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6H730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNAALLMTR ATSLRLSLLL LLSFLPDLDG GVRAKELRFV TLVFRHGDRS
60 70 80 90 100
PIETFPNDPI KESSWPQGFG QLTQLGMAQH YELGQYIRKR YENFLNESYK
110 120 130 140 150
REQVHVRSTD IDRTLMSAMT NLAALFPPEG ISIWNPSLPW QPIPVHTVPV
160 170 180 190 200
SEDQLLYLPF RNCPRFQELQ SETLISEEFQ KRLQPYKDFI EVLPKLTGYH
210 220 230 240 250
DQDLLGIWSK VYDPLFCEGV HNFTLPSWAT EDTMTKLKEI SELSLLSLYG
260 270 280 290 300
IHKQKEKSRL QGGVLINEIL NHMKSATQPS NRRKLIMYSA HDTTVSGLQM
310 320 330 340 350
ALDVYNGILP PYASCHMMEL YFQDGEYFVE MYYRNETRYE PHPLTLPGCT
360 370 380
PSCPLAKFVE LVAPVISQDW SMECAIRNHK GTEDIIN
Length:387
Mass (Da):44,622
Last modified:July 24, 2007 - v1
Checksum:i67241408CDEC7907
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146093 mRNA Translation: AAI46094.1
RefSeqiNP_001092336.1, NM_001098866.1
UniGeneiBt.61011

Genome annotation databases

EnsembliENSBTAT00000015451; ENSBTAP00000015451; ENSBTAG00000011634
GeneIDi504700
KEGGibta:504700

Similar proteinsi

Entry informationi

Entry nameiPPAP_BOVIN
AccessioniPrimary (citable) accession number: A6H730
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 24, 2007
Last modified: April 25, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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