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A6H730 (PPAP_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prostatic acid phosphatase

EC=3.1.3.2
Gene names
Name:ACPP
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma By similarity.

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Subunit structure

Homodimer; dimer formation is required for phosphatase activity By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadenosine metabolic process

Inferred from sequence or structural similarity. Source: UniProt

dephosphorylation

Inferred from sequence or structural similarity. Source: UniProt

nucleotide metabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of adenosine receptor signaling pathway

Inferred from mutant phenotype PubMed 18940592. Source: UniProt

purine nucleobase metabolic process

Inferred from electronic annotation. Source: Ensembl

regulation of sensory perception of pain

Inferred from direct assay PubMed 18940592. Source: UniProt

thiamine metabolic process

Inferred from sequence or structural similarity. Source: UniProt

   Cellular_componentextracellular space

Inferred from sequence or structural similarity. Source: UniProt

filopodium

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: Ensembl

lysosomal membrane

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from sequence or structural similarity. Source: UniProt

vesicle membrane

Inferred from sequence or structural similarity. Source: UniProt

   Molecular_function5'-nucleotidase activity

Inferred from sequence or structural similarity. Source: UniProt

acid phosphatase activity

Inferred from sequence or structural similarity. Source: UniProt

lysophosphatidic acid phosphatase activity

Inferred from sequence or structural similarity. Source: UniProt

phosphatase activity

Inferred from sequence or structural similarity. Source: UniProt

thiamine phosphate phosphatase activity

Inferred from sequence or structural similarity. Source: UniProt

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 387353Prostatic acid phosphatase
PRO_0000356292

Sites

Active site461Nucleophile By similarity
Active site2921Proton donor Probable
Binding site451Substrate By similarity
Binding site491Substrate By similarity
Binding site1131Substrate By similarity
Binding site2911Substrate By similarity
Site511Important for substrate specificity By similarity
Site2081Required for structural stability By similarity

Amino acid modifications

Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation2221N-linked (GlcNAc...) Potential
Glycosylation3351N-linked (GlcNAc...) Potential
Disulfide bond163 ↔ 374 By similarity
Disulfide bond217 ↔ 315 By similarity
Disulfide bond349 ↔ 353 By similarity

Sequences

Sequence LengthMass (Da)Tools
A6H730 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 67241408CDEC7907

FASTA38744,622
        10         20         30         40         50         60 
MRNAALLMTR ATSLRLSLLL LLSFLPDLDG GVRAKELRFV TLVFRHGDRS PIETFPNDPI 

        70         80         90        100        110        120 
KESSWPQGFG QLTQLGMAQH YELGQYIRKR YENFLNESYK REQVHVRSTD IDRTLMSAMT 

       130        140        150        160        170        180 
NLAALFPPEG ISIWNPSLPW QPIPVHTVPV SEDQLLYLPF RNCPRFQELQ SETLISEEFQ 

       190        200        210        220        230        240 
KRLQPYKDFI EVLPKLTGYH DQDLLGIWSK VYDPLFCEGV HNFTLPSWAT EDTMTKLKEI 

       250        260        270        280        290        300 
SELSLLSLYG IHKQKEKSRL QGGVLINEIL NHMKSATQPS NRRKLIMYSA HDTTVSGLQM 

       310        320        330        340        350        360 
ALDVYNGILP PYASCHMMEL YFQDGEYFVE MYYRNETRYE PHPLTLPGCT PSCPLAKFVE 

       370        380 
LVAPVISQDW SMECAIRNHK GTEDIIN 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC146093 mRNA. Translation: AAI46094.1.
RefSeqNP_001092336.1. NM_001098866.1.
UniGeneBt.61011.

3D structure databases

ProteinModelPortalA6H730.
SMRA6H730. Positions 35-374.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000015451.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000015451; ENSBTAP00000015451; ENSBTAG00000011634.
GeneID504700.
KEGGbta:504700.

Organism-specific databases

CTD55.

Phylogenomic databases

eggNOGNOG85977.
GeneTreeENSGT00530000062956.
HOGENOMHOG000231439.
HOVERGENHBG002203.
InParanoidA6H730.
KOK14410.
OMAFTLPSWA.
OrthoDBEOG7GXPBJ.
TreeFamTF312893.

Family and domain databases

Gene3D3.40.50.1240. 1 hit.
InterProIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMSSF53254. SSF53254. 1 hit.
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20866790.

Entry information

Entry namePPAP_BOVIN
AccessionPrimary (citable) accession number: A6H730
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 24, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families