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A6H6M1

- A6H6M1_MOUSE

UniProt

A6H6M1 - A6H6M1_MOUSE

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Protein
Submitted name:

CD3 antigen epsilon polypeptide

Gene

Cd3e

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. signal transducer activity Source: MGI
  2. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. apoptotic signaling pathway Source: MGI
  2. cell surface receptor signaling pathway Source: MGI
  3. lymphocyte activation Source: MGI
  4. negative regulation of smoothened signaling pathway Source: MGI
  5. negative thymic T cell selection Source: MGI
  6. positive regulation of alpha-beta T cell proliferation Source: MGI
  7. positive regulation of calcium-mediated signaling Source: MGI
  8. positive regulation of interferon-gamma production Source: MGI
  9. positive regulation of interleukin-2 biosynthetic process Source: MGI
  10. positive regulation of interleukin-4 production Source: MGI
  11. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  12. positive regulation of T cell activation Source: MGI
  13. positive regulation of T cell anergy Source: MGI
  14. positive regulation of T cell proliferation Source: MGI
  15. response to nutrient Source: Ensembl
  16. T cell costimulation Source: MGI
  17. T cell receptor signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
CD3 antigen epsilon polypeptideImported
Submitted name:
CD3 antigen, epsilon polypeptideImported
Gene namesi
Name:Cd3eImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88332. Cd3e.

Subcellular locationi

GO - Cellular componenti

  1. alpha-beta T cell receptor complex Source: MGI
  2. cell-cell junction Source: MGI
  3. external side of plasma membrane Source: MGI
  4. immunological synapse Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriA6H6M1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099896.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG102121.
KOiK06451.
OMAiDIEWIST.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PfamiPF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6H6M1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRWNTFWGIL CLSLLAVGTC QDDAENIEYK VSISGTSVEL TCPLDSDENL
60 70 80 90 100
KWEKNGQELP QKHDKHLVLQ DFSEVEDSGY YVCYTPASNK NTYLYLKARV
110 120 130 140 150
CEYCVEVDLT AVAIIIIVDI CITLGLLMVI YYWSKNRKAK AKPVTRGTGA
160 170 180
GSRPRGQNKE RPPPVPNPDY EPIRKGQRDL YSGLNQRAV
Length:189
Mass (Da):21,393
Last modified:July 24, 2007 - v1
Checksum:i5CE92F784FA13B96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC145926 mRNA. Translation: AAI45927.1.
BC145954 mRNA. Translation: AAI45955.1.
GU456631 mRNA. Translation: ADD13994.1.
RefSeqiNP_031674.1. NM_007648.4.
XP_006510029.1. XM_006509966.1.
UniGeneiMm.210361.

Genome annotation databases

GeneIDi12501.
KEGGimmu:12501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC145926 mRNA. Translation: AAI45927.1 .
BC145954 mRNA. Translation: AAI45955.1 .
GU456631 mRNA. Translation: ADD13994.1 .
RefSeqi NP_031674.1. NM_007648.4.
XP_006510029.1. XM_006509966.1.
UniGenei Mm.210361.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000099896.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 12501.
KEGGi mmu:12501.

Organism-specific databases

CTDi 916.
MGIi MGI:88332. Cd3e.

Phylogenomic databases

HOVERGENi HBG102121.
KOi K06451.
OMAi DIEWIST.

Miscellaneous databases

NextBioi 281450.
SOURCEi Search...

Gene expression databases

Genevestigatori A6H6M1.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR015484. CD3_esu/gsu/dsu.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view ]
PANTHERi PTHR10570. PTHR10570. 1 hit.
Pfami PF02189. ITAM. 1 hit.
[Graphical view ]
SMARTi SM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  2. "Polymorphisms of the T cell receptor CD3delta and CD3epsilon chains affect anti-CD3 antibody binding and T cell activation."
    Boding L., Nielsen M.W., Bonefeld C.M., von Essen M.R., Nielsen B.L., Lauritsen J.P., Hansen A.K., Nielsen M.M., Kongsbak M., Rubin M., Vennegaard M.T., Odum N., Geisler C.
    Mol. Immunol. 47:2450-2457(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.

Entry informationi

Entry nameiA6H6M1_MOUSE
AccessioniPrimary (citable) accession number: A6H6M1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)