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A6H6M1 (A6H6M1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

CD3 antigen, epsilon polypeptide EMBL AAI45927.1
Gene names
Name:Cd3e MGI 88332 EMBL AAI45927.1
OrganismMus musculus (Mouse) EMBL AAI45927.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processT cell costimulation

Inferred from genetic interaction PubMed 23793062. Source: MGI

T cell receptor signaling pathway

Inferred from direct assay PubMed 10485657. Source: MGI

apoptotic signaling pathway

Inferred from direct assay PubMed 8666928. Source: MGI

cell surface receptor signaling pathway

Inferred from direct assay PubMed 7630421PubMed 8943715. Source: MGI

lymphocyte activation

Inferred from mutant phenotype PubMed 15843560. Source: MGI

negative regulation of smoothened signaling pathway

Inferred from direct assay PubMed 10981962. Source: MGI

negative thymic T cell selection

Inferred from direct assay PubMed 7630421. Source: MGI

positive regulation of T cell activation

Inferred from direct assay PubMed 12874832. Source: MGI

positive regulation of T cell anergy

Inferred from direct assay PubMed 14973438. Source: MGI

positive regulation of T cell proliferation

Inferred from direct assay PubMed 10072077PubMed 10485657PubMed 12874832PubMed 15368291. Source: MGI

positive regulation of alpha-beta T cell proliferation

Inferred from direct assay PubMed 11894097PubMed 14973438PubMed 8125140. Source: MGI

positive regulation of calcium-mediated signaling

Inferred from direct assay PubMed 7630421PubMed 8943715. Source: MGI

positive regulation of interferon-gamma production

Inferred from direct assay PubMed 11894097. Source: MGI

positive regulation of interleukin-2 biosynthetic process

Inferred from direct assay PubMed 12874832. Source: MGI

positive regulation of interleukin-4 production

Inferred from direct assay PubMed 11894097. Source: MGI

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from direct assay PubMed 10485657. Source: MGI

response to nutrient

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentalpha-beta T cell receptor complex

Inferred from direct assay PubMed 9064344PubMed 9208839. Source: MGI

cell-cell junction

Inferred from direct assay PubMed 23793062. Source: MGI

external side of plasma membrane

Inferred from direct assay PubMed 10072077PubMed 10485657PubMed 15368291PubMed 17277142PubMed 19838199PubMed 20660734PubMed 20709950PubMed 22732588PubMed 7630421PubMed 8125140PubMed 8666928PubMed 8755570. Source: MGI

immunological synapse

Inferred from direct assay PubMed 14635057PubMed 15064761. Source: MGI

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 11390434PubMed 8196616. Source: MGI

signal transducer activity

Inferred from direct assay PubMed 7630421. Source: MGI

transmembrane signaling receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A6H6M1 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 5CE92F784FA13B96

FASTA18921,393
        10         20         30         40         50         60 
MRWNTFWGIL CLSLLAVGTC QDDAENIEYK VSISGTSVEL TCPLDSDENL KWEKNGQELP 

        70         80         90        100        110        120 
QKHDKHLVLQ DFSEVEDSGY YVCYTPASNK NTYLYLKARV CEYCVEVDLT AVAIIIIVDI 

       130        140        150        160        170        180 
CITLGLLMVI YYWSKNRKAK AKPVTRGTGA GSRPRGQNKE RPPPVPNPDY EPIRKGQRDL 


YSGLNQRAV 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain EMBL AAI45927.1.
[2]"Polymorphisms of the T cell receptor CD3delta and CD3epsilon chains affect anti-CD3 antibody binding and T cell activation."
Boding L., Nielsen M.W., Bonefeld C.M., von Essen M.R., Nielsen B.L., Lauritsen J.P., Hansen A.K., Nielsen M.M., Kongsbak M., Rubin M., Vennegaard M.T., Odum N., Geisler C.
Mol. Immunol. 47:2450-2457(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6 EMBL ADD13994.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC145926 mRNA. Translation: AAI45927.1.
BC145954 mRNA. Translation: AAI45955.1.
GU456631 mRNA. Translation: ADD13994.1.
RefSeqNP_031674.1. NM_007648.4.
XP_006510029.1. XM_006509966.1.
UniGeneMm.210361.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000099896.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID12501.
KEGGmmu:12501.

Organism-specific databases

CTD916.
MGIMGI:88332. Cd3e.

Phylogenomic databases

HOVERGENHBG102121.
InParanoidA6H6M1.
KOK06451.
OMADIEWIST.

Gene expression databases

GenevestigatorA6H6M1.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR015484. CD3_esu/gsu/dsu.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERPTHR10570. PTHR10570. 1 hit.
PfamPF02189. ITAM. 1 hit.
[Graphical view]
SMARTSM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281450.
SOURCESearch...

Entry information

Entry nameA6H6M1_MOUSE
AccessionPrimary (citable) accession number: A6H6M1
Entry history
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)