A6H6M1 (A6H6M1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
CD3 antigen epsilon polypeptide EMBL ADD13994.1

Submitted name:
CD3 antigen, epsilon polypeptide EMBL AAI45927.1

Gene names

Name:

Cd3e MGI 88332 EMBL AAI45927.1

Organism

Mus musculus (Mouse) EMBL AAI45927.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	T cell costimulation Inferred from genetic interaction PubMed 23793062. Source: MGI T cell receptor signaling pathway Inferred from direct assay PubMed 10485657. Source: MGI apoptotic signaling pathway Inferred from direct assay PubMed 8666928. Source: MGI cell surface receptor signaling pathway Inferred from direct assay PubMed 7630421PubMed 8943715. Source: MGI lymphocyte activation Inferred from mutant phenotype PubMed 15843560. Source: MGI negative regulation of smoothened signaling pathway Inferred from direct assay PubMed 10981962. Source: MGI negative thymic T cell selection Inferred from direct assay PubMed 7630421. Source: MGI positive regulation of T cell activation Inferred from direct assay PubMed 12874832. Source: MGI positive regulation of T cell anergy Inferred from direct assay PubMed 14973438. Source: MGI positive regulation of T cell proliferation Inferred from direct assay PubMed 10072077PubMed 10485657PubMed 12874832PubMed 15368291. Source: MGI positive regulation of alpha-beta T cell proliferation Inferred from direct assay PubMed 11894097PubMed 14973438PubMed 8125140. Source: MGI positive regulation of calcium-mediated signaling Inferred from direct assay PubMed 7630421PubMed 8943715. Source: MGI positive regulation of interferon-gamma production Inferred from direct assay PubMed 11894097. Source: MGI positive regulation of interleukin-2 biosynthetic process Inferred from direct assay PubMed 12874832. Source: MGI positive regulation of interleukin-4 production Inferred from direct assay PubMed 11894097. Source: MGI positive regulation of peptidyl-tyrosine phosphorylation Inferred from direct assay PubMed 10485657. Source: MGI response to nutrient Inferred from electronic annotation. Source: Ensembl
Cellular_component	alpha-beta T cell receptor complex Inferred from direct assay PubMed 9064344PubMed 9208839. Source: MGI cell-cell junction Inferred from direct assay PubMed 23793062. Source: MGI external side of plasma membrane Inferred from direct assay PubMed 10072077PubMed 10485657PubMed 15368291PubMed 17277142PubMed 19838199PubMed 20660734PubMed 20709950PubMed 22732588PubMed 7630421PubMed 8125140PubMed 8666928PubMed 8755570. Source: MGI immunological synapse Inferred from direct assay PubMed 14635057PubMed 15064761. Source: MGI
Molecular_function	protein binding Inferred from physical interaction PubMed 11390434PubMed 8196616. Source: MGI signal transducer activity Inferred from direct assay PubMed 7630421. Source: MGI transmembrane signaling receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A6H6M1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 5CE92F784FA13B96	FASTA	189	21,393
	10 20 30 40 50 60 MRWNTFWGIL CLSLLAVGTC QDDAENIEYK VSISGTSVEL TCPLDSDENL KWEKNGQELP 70 80 90 100 110 120 QKHDKHLVLQ DFSEVEDSGY YVCYTPASNK NTYLYLKARV CEYCVEVDLT AVAIIIIVDI 130 140 150 160 170 180 CITLGLLMVI YYWSKNRKAK AKPVTRGTGA GSRPRGQNKE RPPPVPNPDY EPIRKGQRDL YSGLNQRAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAI45927.1.
[2]	"Polymorphisms of the T cell receptor CD3delta and CD3epsilon chains affect anti-CD3 antibody binding and T cell activation." Boding L., Nielsen M.W., Bonefeld C.M., von Essen M.R., Nielsen B.L., Lauritsen J.P., Hansen A.K., Nielsen M.M., Kongsbak M., Rubin M., Vennegaard M.T., Odum N., Geisler C. Mol. Immunol. 47:2450-2457(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6 EMBL ADD13994.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC145926 mRNA. Translation: AAI45927.1. BC145954 mRNA. Translation: AAI45955.1. GU456631 mRNA. Translation: ADD13994.1.
RefSeq	NP_031674.1. NM_007648.4. XP_006510029.1. XM_006509966.1.
UniGene	Mm.210361.
3D structure databases
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000099896.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	12501.
KEGG	mmu:12501.
Organism-specific databases
CTD	916.
MGI	MGI:88332. Cd3e.
Phylogenomic databases
HOVERGEN	HBG102121.
InParanoid	A6H6M1.
KO	K06451.
OMA	DIEWIST.
Gene expression databases
Genevestigator	A6H6M1.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR015484. CD3_esu/gsu/dsu. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003598. Ig_sub2. IPR003110. Phos_immunorcpt_sig_ITAM. [Graphical view]
PANTHER	PTHR10570. PTHR10570. 1 hit.
Pfam	PF02189. ITAM. 1 hit. [Graphical view]
SMART	SM00408. IGc2. 1 hit. SM00077. ITAM. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. PS51055. ITAM_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	281450.
SOURCE	Search...

Entry information

Entry name

A6H6M1_MOUSE

Accession

Primary (citable) accession number: A6H6M1

Entry history

Integrated into UniProtKB/TrEMBL:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)