Cd3e

Functionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
SH3 domain binding Source: Ensembl
transmembrane signaling receptor activity Source: InterPro

GO - Biological processⁱ

apoptotic signaling pathway Source: Ensembl
negative regulation of gene expression Source: Ensembl
negative regulation of smoothened signaling pathway Source: Ensembl
negative thymic T cell selection Source: Ensembl
positive regulation of alpha-beta T cell proliferation Source: Ensembl
positive regulation of calcium-mediated signaling Source: Ensembl
positive regulation of gene expression Source: Ensembl
positive regulation of interferon-gamma production Source: Ensembl
positive regulation of interleukin-2 biosynthetic process Source: Ensembl
positive regulation of interleukin-4 production Source: Ensembl
positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
positive regulation of T cell anergy Source: Ensembl
protein homooligomerization Source: Ensembl
response to nutrient Source: Ensembl
T cell costimulation Source: Ensembl
T cell receptor signaling pathway Source: Ensembl

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: CD3 antigen epsilon polypeptideImported Submitted name: CD3 antigen, epsilon polypeptideImported
Gene namesⁱ	Name:Cd3eImported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:88332. Cd3e.

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	109 – 133	HelicalSequence analysisAdd BLAST		25

GO - Cellular componentⁱ

alpha-beta T cell receptor complex Source: Ensembl
cell-cell junction Source: Ensembl
external side of plasma membrane Source: Ensembl
immunological synapse Source: Ensembl
integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_5010103262	21 – 189	Sequence analysisAdd BLAST		169

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000032093.
ExpressionAtlasⁱ	A6H6M1. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
SH3 domain binding Source: Ensembl

Complete GO annotation...

Structureⁱ

3D structure databases

SMRⁱ	A6H6M1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	35 – 83	Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST		49

Keywords - Domainⁱ

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IYD1. Eukaryota. ENOG41123JN. LUCA.
HOVERGENⁱ	HBG102121.
KEGG Orthology (KO) More...KOⁱ	K06451.
OMAⁱ	QRGQNKE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PKE.

Family and domain databases

Gene3Dⁱ	2.60.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR015484. CD3_esu/gsu/dsu. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003598. Ig_sub2. IPR003110. Phos_immunorcpt_sig_ITAM.
PANTHERⁱ	PTHR10570. PTHR10570. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02189. ITAM. 1 hit.
SMARTⁱ	View protein in SMART SM00408. IGc2. 1 hit. SM00077. ITAM. 1 hit.
SUPFAMⁱ	SSF48726. SSF48726. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS51055. ITAM_1. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A6H6M1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRWNTFWGIL CLSLLAVGTC QDDAENIEYK VSISGTSVEL TCPLDSDENL 
        60         70         80         90        100
KWEKNGQELP QKHDKHLVLQ DFSEVEDSGY YVCYTPASNK NTYLYLKARV 
       110        120        130        140        150
CEYCVEVDLT AVAIIIIVDI CITLGLLMVI YYWSKNRKAK AKPVTRGTGA 
       160        170        180 
GSRPRGQNKE RPPPVPNPDY EPIRKGQRDL YSGLNQRAV

Length:189

Mass (Da):21,393

Last modified:July 24, 2007 - v1

Checksum:ⁱ5CE92F784FA13B96

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC145926 mRNA. Translation: AAI45927.1. BC145954 mRNA. Translation: AAI45955.1. GU456631 mRNA. Translation: ADD13994.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_031674.1. NM_007648.4. XP_006510029.1. XM_006509966.3.
UniGeneⁱ	Mm.210361.

Genome annotation databases

GeneIDⁱ	12501.
KEGGⁱ	mmu:12501.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC145926 mRNA. Translation: AAI45927.1. BC145954 mRNA. Translation: AAI45955.1. GU456631 mRNA. Translation: ADD13994.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_031674.1. NM_007648.4. XP_006510029.1. XM_006509966.3.
UniGeneⁱ	Mm.210361.

3D structure databases

SMRⁱ	A6H6M1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	12501.
KEGGⁱ	mmu:12501.

Organism-specific databases

CTDⁱ	916.
MGIⁱ	MGI:88332. Cd3e.

Phylogenomic databases

eggNOGⁱ	ENOG410IYD1. Eukaryota. ENOG41123JN. LUCA.
HOVERGENⁱ	HBG102121.
KEGG Orthology (KO) More...KOⁱ	K06451.
OMAⁱ	QRGQNKE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PKE.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000032093.
ExpressionAtlasⁱ	A6H6M1. baseline and differential.

Family and domain databases

Gene3Dⁱ	2.60.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR015484. CD3_esu/gsu/dsu. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003598. Ig_sub2. IPR003110. Phos_immunorcpt_sig_ITAM.
PANTHERⁱ	PTHR10570. PTHR10570. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02189. ITAM. 1 hit.
SMARTⁱ	View protein in SMART SM00408. IGc2. 1 hit. SM00077. ITAM. 1 hit.
SUPFAMⁱ	SSF48726. SSF48726. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS51055. ITAM_1. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A6H6M1_MOUSE
Accessionⁱ	A6H6M1Primary (citable) accession number: A6H6M1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 24, 2007
	Last sequence update:	July 24, 2007
	Last modified:	July 5, 2017
	This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB

UniParc

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Supporting data

UniProtKB - A6H6M1 (A6H6M1_MOUSE)

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CD3 antigen epsilon polypeptide

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ