UniProtKB - A6H6M1 (A6H6M1_MOUSE)
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Protein
Submitted name:
CD3 antigen epsilon polypeptide
Gene
Cd3e
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- SH3 domain binding Source: Ensembl
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- apoptotic signaling pathway Source: Ensembl
- cerebellum development Source: Ensembl
- dendrite development Source: Ensembl
- negative regulation of gene expression Source: Ensembl
- negative regulation of smoothened signaling pathway Source: Ensembl
- negative thymic T cell selection Source: Ensembl
- positive regulation of alpha-beta T cell proliferation Source: Ensembl
- positive regulation of calcium-mediated signaling Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- positive regulation of interferon-gamma production Source: Ensembl
- positive regulation of interleukin-2 biosynthetic process Source: Ensembl
- positive regulation of interleukin-4 production Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- positive regulation of T cell anergy Source: Ensembl
- protein homooligomerization Source: Ensembl
- response to nutrient Source: Ensembl
- T cell costimulation Source: Ensembl
- T cell receptor signaling pathway Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: CD3 antigen epsilon polypeptideImportedSubmitted name: CD3 antigen, epsilon polypeptideImported |
Gene namesi | Name:Cd3eImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:88332. Cd3e. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 109 – 133 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5014083904 | 21 – 189 | Sequence analysisAdd BLAST | 169 |
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- SH3 domain binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 83 | Ig-likeInterPro annotationAdd BLAST | 49 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG410IYD1. Eukaryota. ENOG41123JN. LUCA. |
HOVERGENi | HBG102121. |
KOi | K06451. |
OMAi | QRGQNKE. |
OrthoDBi | EOG091G0PKE. |
Family and domain databases
Gene3Di | 2.60.40.10. 1 hit. |
InterProi | View protein in InterPro IPR015484. CD3_esu/gsu/dsu. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig-like_fold. IPR003598. Ig_sub2. IPR003110. Phos_immunorcpt_sig_ITAM. |
PANTHERi | PTHR10570. PTHR10570. 1 hit. |
Pfami | View protein in Pfam PF02189. ITAM. 1 hit. |
SMARTi | View protein in SMART SM00408. IGc2. 1 hit. SM00077. ITAM. 1 hit. |
SUPFAMi | SSF48726. SSF48726. 1 hit. |
PROSITEi | View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS51055. ITAM_1. 1 hit. |
i Sequence
Sequence statusi: Complete.
A6H6M1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRWNTFWGIL CLSLLAVGTC QDDAENIEYK VSISGTSVEL TCPLDSDENL
60 70 80 90 100
KWEKNGQELP QKHDKHLVLQ DFSEVEDSGY YVCYTPASNK NTYLYLKARV
110 120 130 140 150
CEYCVEVDLT AVAIIIIVDI CITLGLLMVI YYWSKNRKAK AKPVTRGTGA
160 170 180
GSRPRGQNKE RPPPVPNPDY EPIRKGQRDL YSGLNQRAV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC145926 mRNA. Translation: AAI45927.1. BC145954 mRNA. Translation: AAI45955.1. GU456631 mRNA. Translation: ADD13994.1. |
RefSeqi | NP_031674.1. NM_007648.4. XP_006510029.1. XM_006509966.3. |
UniGenei | Mm.210361. |
Genome annotation databases
GeneIDi | 12501. |
KEGGi | mmu:12501. |
Similar proteinsi
Entry informationi
Entry namei | A6H6M1_MOUSE | |
Accessioni | A6H6M1Primary (citable) accession number: A6H6M1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 24, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | March 28, 2018 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |