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A6H6M1

- A6H6M1_MOUSE

UniProt

A6H6M1 - A6H6M1_MOUSE

Protein
Submitted name:

CD3 antigen epsilon polypeptide

Gene

Cd3e

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. signal transducer activity Source: MGI
    3. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. apoptotic signaling pathway Source: MGI
    2. cell surface receptor signaling pathway Source: MGI
    3. lymphocyte activation Source: MGI
    4. negative regulation of smoothened signaling pathway Source: MGI
    5. negative thymic T cell selection Source: MGI
    6. positive regulation of alpha-beta T cell proliferation Source: MGI
    7. positive regulation of calcium-mediated signaling Source: MGI
    8. positive regulation of interferon-gamma production Source: MGI
    9. positive regulation of interleukin-2 biosynthetic process Source: MGI
    10. positive regulation of interleukin-4 production Source: MGI
    11. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
    12. positive regulation of T cell activation Source: MGI
    13. positive regulation of T cell anergy Source: MGI
    14. positive regulation of T cell proliferation Source: MGI
    15. response to nutrient Source: Ensembl
    16. T cell costimulation Source: MGI
    17. T cell receptor signaling pathway Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    CD3 antigen epsilon polypeptideImported
    Submitted name:
    CD3 antigen, epsilon polypeptideImported
    Gene namesi
    Name:Cd3eImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:88332. Cd3e.

    Subcellular locationi

    GO - Cellular componenti

    1. alpha-beta T cell receptor complex Source: MGI
    2. cell-cell junction Source: MGI
    3. external side of plasma membrane Source: MGI
    4. immunological synapse Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriA6H6M1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000099896.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG102121.
    InParanoidiA6H6M1.
    KOiK06451.
    OMAiDIEWIST.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR015484. CD3_esu/gsu/dsu.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR003110. Phos_immunorcpt_sig_ITAM.
    [Graphical view]
    PANTHERiPTHR10570. PTHR10570. 1 hit.
    PfamiPF02189. ITAM. 1 hit.
    [Graphical view]
    SMARTiSM00408. IGc2. 1 hit.
    SM00077. ITAM. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51055. ITAM_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6H6M1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRWNTFWGIL CLSLLAVGTC QDDAENIEYK VSISGTSVEL TCPLDSDENL    50
    KWEKNGQELP QKHDKHLVLQ DFSEVEDSGY YVCYTPASNK NTYLYLKARV 100
    CEYCVEVDLT AVAIIIIVDI CITLGLLMVI YYWSKNRKAK AKPVTRGTGA 150
    GSRPRGQNKE RPPPVPNPDY EPIRKGQRDL YSGLNQRAV 189
    Length:189
    Mass (Da):21,393
    Last modified:July 24, 2007 - v1
    Checksum:i5CE92F784FA13B96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC145926 mRNA. Translation: AAI45927.1.
    BC145954 mRNA. Translation: AAI45955.1.
    GU456631 mRNA. Translation: ADD13994.1.
    RefSeqiNP_031674.1. NM_007648.4.
    XP_006510029.1. XM_006509966.1.
    UniGeneiMm.210361.

    Genome annotation databases

    GeneIDi12501.
    KEGGimmu:12501.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC145926 mRNA. Translation: AAI45927.1 .
    BC145954 mRNA. Translation: AAI45955.1 .
    GU456631 mRNA. Translation: ADD13994.1 .
    RefSeqi NP_031674.1. NM_007648.4.
    XP_006510029.1. XM_006509966.1.
    UniGenei Mm.210361.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000099896.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 12501.
    KEGGi mmu:12501.

    Organism-specific databases

    CTDi 916.
    MGIi MGI:88332. Cd3e.

    Phylogenomic databases

    HOVERGENi HBG102121.
    InParanoidi A6H6M1.
    KOi K06451.
    OMAi DIEWIST.

    Miscellaneous databases

    NextBioi 281450.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori A6H6M1.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR015484. CD3_esu/gsu/dsu.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR003110. Phos_immunorcpt_sig_ITAM.
    [Graphical view ]
    PANTHERi PTHR10570. PTHR10570. 1 hit.
    Pfami PF02189. ITAM. 1 hit.
    [Graphical view ]
    SMARTi SM00408. IGc2. 1 hit.
    SM00077. ITAM. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51055. ITAM_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    2. "Polymorphisms of the T cell receptor CD3delta and CD3epsilon chains affect anti-CD3 antibody binding and T cell activation."
      Boding L., Nielsen M.W., Bonefeld C.M., von Essen M.R., Nielsen B.L., Lauritsen J.P., Hansen A.K., Nielsen M.M., Kongsbak M., Rubin M., Vennegaard M.T., Odum N., Geisler C.
      Mol. Immunol. 47:2450-2457(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6Imported.

    Entry informationi

    Entry nameiA6H6M1_MOUSE
    AccessioniPrimary (citable) accession number: A6H6M1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)