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Protein
Submitted name:

CD3 antigen epsilon polypeptide

Gene

Cd3e

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. protein heterodimerization activity Source: MGI
  2. SH3 domain binding Source: MGI
  3. signal transducer activity Source: MGI
  4. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. apoptotic signaling pathway Source: MGI
  2. cell surface receptor signaling pathway Source: MGI
  3. lymphocyte activation Source: MGI
  4. negative regulation of smoothened signaling pathway Source: MGI
  5. negative thymic T cell selection Source: MGI
  6. positive regulation of alpha-beta T cell proliferation Source: MGI
  7. positive regulation of calcium-mediated signaling Source: MGI
  8. positive regulation of interferon-gamma production Source: MGI
  9. positive regulation of interleukin-2 biosynthetic process Source: MGI
  10. positive regulation of interleukin-4 production Source: MGI
  11. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  12. positive regulation of T cell activation Source: MGI
  13. positive regulation of T cell anergy Source: MGI
  14. positive regulation of T cell proliferation Source: MGI
  15. response to nutrient Source: Ensembl
  16. T cell costimulation Source: MGI
  17. T cell receptor signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
CD3 antigen epsilon polypeptideImported
Submitted name:
CD3 antigen, epsilon polypeptideImported
Gene namesi
Name:Cd3eImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88332. Cd3e.

Subcellular locationi

GO - Cellular componenti

  1. alpha-beta T cell receptor complex Source: MGI
  2. cell-cell junction Source: MGI
  3. external side of plasma membrane Source: MGI
  4. immunological synapse Source: MGI
  5. plasma membrane Source: MGI
  6. T cell receptor complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiA6H6M1.

Expressioni

Gene expression databases

BgeeiA6H6M1.
ExpressionAtlasiA6H6M1. baseline and differential.
GenevestigatoriA6H6M1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099896.

Structurei

3D structure databases

ProteinModelPortaliA6H6M1.
SMRiA6H6M1. Positions 22-100, 134-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG102121.
KOiK06451.
OMAiYLRARVC.
PhylomeDBiA6H6M1.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PfamiPF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6H6M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWNTFWGIL CLSLLAVGTC QDDAENIEYK VSISGTSVEL TCPLDSDENL
60 70 80 90 100
KWEKNGQELP QKHDKHLVLQ DFSEVEDSGY YVCYTPASNK NTYLYLKARV
110 120 130 140 150
CEYCVEVDLT AVAIIIIVDI CITLGLLMVI YYWSKNRKAK AKPVTRGTGA
160 170 180
GSRPRGQNKE RPPPVPNPDY EPIRKGQRDL YSGLNQRAV
Length:189
Mass (Da):21,393
Last modified:July 24, 2007 - v1
Checksum:i5CE92F784FA13B96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC145926 mRNA. Translation: AAI45927.1.
BC145954 mRNA. Translation: AAI45955.1.
GU456631 mRNA. Translation: ADD13994.1.
RefSeqiNP_031674.1. NM_007648.4.
XP_006510029.1. XM_006509966.2.
UniGeneiMm.210361.

Genome annotation databases

GeneIDi12501.
KEGGimmu:12501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC145926 mRNA. Translation: AAI45927.1.
BC145954 mRNA. Translation: AAI45955.1.
GU456631 mRNA. Translation: ADD13994.1.
RefSeqiNP_031674.1. NM_007648.4.
XP_006510029.1. XM_006509966.2.
UniGeneiMm.210361.

3D structure databases

ProteinModelPortaliA6H6M1.
SMRiA6H6M1. Positions 22-100, 134-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099896.

Proteomic databases

PRIDEiA6H6M1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12501.
KEGGimmu:12501.

Organism-specific databases

CTDi916.
MGIiMGI:88332. Cd3e.

Phylogenomic databases

HOVERGENiHBG102121.
KOiK06451.
OMAiYLRARVC.
PhylomeDBiA6H6M1.

Miscellaneous databases

NextBioi281450.
SOURCEiSearch...

Gene expression databases

BgeeiA6H6M1.
ExpressionAtlasiA6H6M1. baseline and differential.
GenevestigatoriA6H6M1.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PfamiPF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  2. "Polymorphisms of the T cell receptor CD3delta and CD3epsilon chains affect anti-CD3 antibody binding and T cell activation."
    Boding L., Nielsen M.W., Bonefeld C.M., von Essen M.R., Nielsen B.L., Lauritsen J.P., Hansen A.K., Nielsen M.M., Kongsbak M., Rubin M., Vennegaard M.T., Odum N., Geisler C.
    Mol. Immunol. 47:2450-2457(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.

Entry informationi

Entry nameiA6H6M1_MOUSE
AccessioniPrimary (citable) accession number: A6H6M1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 1, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.