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Protein

Cytochrome c oxidase subunit 8C, mitochondrial

Gene

Cox8c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide 8 isoform 3
Cytochrome c oxidase polypeptide VIII isoform 3
Short name:
COX VIII-3
Cytochrome c oxidase subunit 8-3
Gene namesi
Name:Cox8c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1922733. Cox8c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 4011Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei41 – 6424HelicalBy similarityAdd
BLAST
Topological domaini65 – 728Mitochondrial intermembraneBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929MitochondrionBy similarityAdd
BLAST
Chaini30 – 7243Cytochrome c oxidase subunit 8C, mitochondrialPRO_0000370690Add
BLAST

Proteomic databases

MaxQBiA6H666.
PaxDbiA6H666.
PRIDEiA6H666.

Expressioni

Gene expression databases

BgeeiA6H666.
GenevisibleiA6H666. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056155.

Structurei

3D structure databases

ProteinModelPortaliA6H666.
SMRiA6H666. Positions 29-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIII family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JK2D. Eukaryota.
ENOG41114SW. LUCA.
GeneTreeiENSGT00680000101615.
InParanoidiA6H666.
KOiK02273.
OMAiHSESPQN.
OrthoDBiEOG72ZCJ7.
PhylomeDBiA6H666.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMiSSF81431. SSF81431. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6H666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLLLLCSS LLRHRAVLFS KPGHPGRLSH SESPQKKILS PTESAVGIVV
60 70
FFTTFYIPAA YVLSSLKYFK GE
Length:72
Mass (Da):8,009
Last modified:July 24, 2007 - v1
Checksum:i2ECDDBD9D196A779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC145768 mRNA. Translation: AAI45769.1.
BC145770 mRNA. Translation: AAI45771.1.
CCDSiCCDS56857.1.
RefSeqiNP_001034138.1. NM_001039049.1.
UniGeneiMm.660.

Genome annotation databases

EnsembliENSMUST00000053611; ENSMUSP00000056155; ENSMUSG00000043319.
GeneIDi75483.
KEGGimmu:75483.
UCSCiuc007ouv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC145768 mRNA. Translation: AAI45769.1.
BC145770 mRNA. Translation: AAI45771.1.
CCDSiCCDS56857.1.
RefSeqiNP_001034138.1. NM_001039049.1.
UniGeneiMm.660.

3D structure databases

ProteinModelPortaliA6H666.
SMRiA6H666. Positions 29-71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056155.

Proteomic databases

MaxQBiA6H666.
PaxDbiA6H666.
PRIDEiA6H666.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053611; ENSMUSP00000056155; ENSMUSG00000043319.
GeneIDi75483.
KEGGimmu:75483.
UCSCiuc007ouv.1. mouse.

Organism-specific databases

CTDi341947.
MGIiMGI:1922733. Cox8c.

Phylogenomic databases

eggNOGiENOG410JK2D. Eukaryota.
ENOG41114SW. LUCA.
GeneTreeiENSGT00680000101615.
InParanoidiA6H666.
KOiK02273.
OMAiHSESPQN.
OrthoDBiEOG72ZCJ7.
PhylomeDBiA6H666.

Miscellaneous databases

PROiA6H666.
SOURCEiSearch...

Gene expression databases

BgeeiA6H666.
GenevisibleiA6H666. MM.

Family and domain databases

Gene3Di4.10.81.10. 1 hit.
InterProiIPR003205. Cyt_c_oxidase_su8.
IPR016070. Cyt_c_oxidase_su8/PSI_RC_su9.
[Graphical view]
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiPF02285. COX8. 1 hit.
[Graphical view]
SUPFAMiSSF81431. SSF81431. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCOX8C_MOUSE
AccessioniPrimary (citable) accession number: A6H666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 24, 2007
Last modified: July 6, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.