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Protein

Cytochrome c oxidase subunit 8C, mitochondrial

Gene

Cox8c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide 8 isoform 3
Cytochrome c oxidase polypeptide VIII isoform 3
Short name:
COX VIII-3
Cytochrome c oxidase subunit 8-3
Gene namesi
Name:Cox8c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1922733 Cox8c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 40Mitochondrial matrixBy similarityAdd BLAST11
Transmembranei41 – 64HelicalBy similarityAdd BLAST24
Topological domaini65 – 72Mitochondrial intermembraneBy similarity8

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000037069030 – 72Cytochrome c oxidase subunit 8C, mitochondrialAdd BLAST43

Proteomic databases

MaxQBiA6H666
PaxDbiA6H666
PRIDEiA6H666

Expressioni

Gene expression databases

BgeeiENSMUSG00000043319
GenevisibleiA6H666 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056155

Structurei

3D structure databases

ProteinModelPortaliA6H666
SMRiA6H666
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIII family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JK2D Eukaryota
ENOG41114SW LUCA
GeneTreeiENSGT00390000012036
InParanoidiA6H666
KOiK02273
OMAiHSESPQN
OrthoDBiEOG091G1A16
PhylomeDBiA6H666

Family and domain databases

Gene3Di4.10.81.10, 1 hit
InterProiView protein in InterPro
IPR003205 Cyt_c_oxidase_su8
IPR036548 Cyt_c_oxidase_su8_sf
PANTHERiPTHR16717 PTHR16717, 1 hit
PfamiView protein in Pfam
PF02285 COX8, 1 hit
SUPFAMiSSF81431 SSF81431, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6H666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLLLLCSS LLRHRAVLFS KPGHPGRLSH SESPQKKILS PTESAVGIVV
60 70
FFTTFYIPAA YVLSSLKYFK GE
Length:72
Mass (Da):8,009
Last modified:July 24, 2007 - v1
Checksum:i2ECDDBD9D196A779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC145768 mRNA Translation: AAI45769.1
BC145770 mRNA Translation: AAI45771.1
CCDSiCCDS56857.1
RefSeqiNP_001034138.1, NM_001039049.1
UniGeneiMm.660

Genome annotation databases

EnsembliENSMUST00000053611; ENSMUSP00000056155; ENSMUSG00000043319
GeneIDi75483
KEGGimmu:75483
UCSCiuc007ouv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCOX8C_MOUSE
AccessioniPrimary (citable) accession number: A6H666
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health