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Protein

Protein-glutamate O-methyltransferase

Gene

Armt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response.By similarity

Catalytic activityi

S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei256S-adenosyl-L-methionineBy similarity1
Binding sitei289S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

DNA damage

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamate O-methyltransferaseBy similarity (EC:2.1.1.-By similarity)
Alternative name(s):
Acidic residue methyltransferase 1By similarity
Gene namesi
Name:Armt1By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1920669. Armt1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003589252 – 439Protein-glutamate O-methyltransferaseAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei4PhosphoserineBy similarity1
Modified residuei40N6-acetyllysineBy similarity1

Post-translational modificationi

Automethylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiA6H630.
MaxQBiA6H630.
PaxDbiA6H630.
PeptideAtlasiA6H630.
PRIDEiA6H630.

PTM databases

iPTMnetiA6H630.
PhosphoSitePlusiA6H630.

Expressioni

Gene expression databases

BgeeiENSMUSG00000061759.
ExpressionAtlasiA6H630. baseline and differential.
GenevisibleiA6H630. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093581.

Structurei

3D structure databases

ProteinModelPortaliA6H630.
SMRiA6H630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARMT1 family.Curated

Phylogenomic databases

eggNOGiKOG3870. Eukaryota.
ENOG410XPAF. LUCA.
GeneTreeiENSGT00530000064023.
HOGENOMiHOG000172710.
HOVERGENiHBG054833.
InParanoidiA6H630.
OMAiQGKDFMN.
OrthoDBiEOG091G0557.
PhylomeDBiA6H630.
TreeFamiTF314853.

Family and domain databases

InterProiIPR002791. DUF89.
[Graphical view]
PfamiPF01937. DUF89. 1 hit.
[Graphical view]
SUPFAMiSSF111321. SSF111321. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6H630-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAESPAFLSA KDEGSFAYLT IKDRTPQILT KVIDTLHRHK SEFFEKHGEE
60 70 80 90 100
GIEAEKKAIS LLSKLRNELQ TDKPITPLVD KCVDTHIWNQ YLEYQRSLLN
110 120 130 140 150
EGDGEPRWFF SPWLFVECYM YRRIHEAIMQ SPPIHDFDVF KESKEENFFE
160 170 180 190 200
SQGSIDALCS HLLQLKPVKG LREEQIQDEF FKLLQISLWG NKCDLSLSGG
210 220 230 240 250
ESSSQKANII NCLQDLKPFI LINDTESLWA LLSKLKKTVE TPVVRVDIVL
260 270 280 290 300
DNSGFELITD LVLADFLFSS ELATEIHFHG KSIPWFVSDV TEHDFNWIVE
310 320 330 340 350
HMKSSNLESM STCGACWEAY ARMGRWAYHD HAFWTLPHPY CVMPQVAPDL
360 370 380 390 400
YAELQKAHLI LFKGDLNYRK LMGDRKWKFT FPFHQALSGF HPAPLCSIRT
410 420 430
LKCELQVGLQ PGQAEQLTAS DPHWLTTGRY GILQFDGPL
Length:439
Mass (Da):50,549
Last modified:July 24, 2007 - v1
Checksum:i86C98D716BD9996B
GO
Isoform 2 (identifier: A6H630-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-208: ISLWGNKCDLSLSGGESSSQKAN → VYKEYSTQDPMQPRRVMQTVTLQ
     209-439: Missing.

Show »
Length:208
Mass (Da):24,535
Checksum:iECF61CDD6B8426F9
GO
Isoform 3 (identifier: A6H630-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MAESPAFLSAKDEG → MLW
     131-132: SP → RF
     133-439: Missing.

Show »
Length:121
Mass (Da):14,635
Checksum:iDA92A43F291CD517
GO
Isoform 4 (identifier: A6H630-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-136: SPPIHD → RQVYSQ
     137-439: Missing.

Show »
Length:136
Mass (Da):16,097
Checksum:iBB05EF5FC2FA76FC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0361331 – 14MAESP…AKDEG → MLW in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_036134131 – 136SPPIHD → RQVYSQ in isoform 4. 1 Publication6
Alternative sequenceiVSP_036135131 – 132SP → RF in isoform 3. 1 Publication2
Alternative sequenceiVSP_036136133 – 439Missing in isoform 3. 1 PublicationAdd BLAST307
Alternative sequenceiVSP_036137137 – 439Missing in isoform 4. 1 PublicationAdd BLAST303
Alternative sequenceiVSP_036138186 – 208ISLWG…SQKAN → VYKEYSTQDPMQPRRVMQTV TLQ in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_036139209 – 439Missing in isoform 2. 1 PublicationAdd BLAST231

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006776 mRNA. Translation: BAB24735.1.
AC133902 Genomic DNA. No translation available.
CH466562 Genomic DNA. Translation: EDL03585.1.
CH466562 Genomic DNA. Translation: EDL03588.1.
BC002139 mRNA. Translation: AAH02139.1.
BC099894 mRNA. Translation: AAH99894.1.
BC138908 mRNA. Translation: AAI38909.1.
BC145732 mRNA. Translation: AAI45733.1.
CCDSiCCDS56676.1. [A6H630-1]
RefSeqiNP_077223.2. NM_024261.2. [A6H630-1]
UniGeneiMm.346733.

Genome annotation databases

EnsembliENSMUST00000095893; ENSMUSP00000093581; ENSMUSG00000061759. [A6H630-1]
ENSMUST00000117489; ENSMUSP00000114025; ENSMUSG00000061759. [A6H630-4]
ENSMUST00000118544; ENSMUSP00000114073; ENSMUSG00000061759. [A6H630-2]
GeneIDi73419.
KEGGimmu:73419.
UCSCiuc007egy.1. mouse. [A6H630-1]
uc007egz.1. mouse. [A6H630-2]
uc007ehb.1. mouse. [A6H630-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006776 mRNA. Translation: BAB24735.1.
AC133902 Genomic DNA. No translation available.
CH466562 Genomic DNA. Translation: EDL03585.1.
CH466562 Genomic DNA. Translation: EDL03588.1.
BC002139 mRNA. Translation: AAH02139.1.
BC099894 mRNA. Translation: AAH99894.1.
BC138908 mRNA. Translation: AAI38909.1.
BC145732 mRNA. Translation: AAI45733.1.
CCDSiCCDS56676.1. [A6H630-1]
RefSeqiNP_077223.2. NM_024261.2. [A6H630-1]
UniGeneiMm.346733.

3D structure databases

ProteinModelPortaliA6H630.
SMRiA6H630.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093581.

PTM databases

iPTMnetiA6H630.
PhosphoSitePlusiA6H630.

Proteomic databases

EPDiA6H630.
MaxQBiA6H630.
PaxDbiA6H630.
PeptideAtlasiA6H630.
PRIDEiA6H630.

Protocols and materials databases

DNASUi73419.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095893; ENSMUSP00000093581; ENSMUSG00000061759. [A6H630-1]
ENSMUST00000117489; ENSMUSP00000114025; ENSMUSG00000061759. [A6H630-4]
ENSMUST00000118544; ENSMUSP00000114073; ENSMUSG00000061759. [A6H630-2]
GeneIDi73419.
KEGGimmu:73419.
UCSCiuc007egy.1. mouse. [A6H630-1]
uc007egz.1. mouse. [A6H630-2]
uc007ehb.1. mouse. [A6H630-4]

Organism-specific databases

CTDi79624.
MGIiMGI:1920669. Armt1.

Phylogenomic databases

eggNOGiKOG3870. Eukaryota.
ENOG410XPAF. LUCA.
GeneTreeiENSGT00530000064023.
HOGENOMiHOG000172710.
HOVERGENiHBG054833.
InParanoidiA6H630.
OMAiQGKDFMN.
OrthoDBiEOG091G0557.
PhylomeDBiA6H630.
TreeFamiTF314853.

Miscellaneous databases

PROiA6H630.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061759.
ExpressionAtlasiA6H630. baseline and differential.
GenevisibleiA6H630. MM.

Family and domain databases

InterProiIPR002791. DUF89.
[Graphical view]
PfamiPF01937. DUF89. 1 hit.
[Graphical view]
SUPFAMiSSF111321. SSF111321. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARMT1_MOUSE
AccessioniPrimary (citable) accession number: A6H630
Secondary accession number(s): Q499H1, Q99M05, Q9D9L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.