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Protein

PHD and RING finger domain-containing protein 1

Gene

Phrf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri109 – 15042RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri185 – 23551PHD-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PHD and RING finger domain-containing protein 1Imported
Gene namesi
Name:Phrf1Imported
Synonyms:Kiaa1542
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2141847. Phrf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16821682PHD and RING finger domain-containing protein 1PRO_0000354662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei332 – 3321PhosphothreonineBy similarity
Modified residuei447 – 4471PhosphoserineBy similarity
Modified residuei457 – 4571PhosphoserineBy similarity
Modified residuei845 – 8451PhosphoserineBy similarity
Modified residuei846 – 8461PhosphoserineBy similarity
Modified residuei864 – 8641PhosphoserineBy similarity
Modified residuei867 – 8671PhosphoserineBy similarity
Modified residuei919 – 9191PhosphoserineCombined sources
Modified residuei982 – 9821PhosphoserineBy similarity
Modified residuei1000 – 10001PhosphoserineBy similarity
Modified residuei1135 – 11351PhosphoserineBy similarity
Modified residuei1201 – 12011PhosphoserineBy similarity
Modified residuei1368 – 13681PhosphoserineBy similarity
Modified residuei1379 – 13791PhosphoserineBy similarity
Modified residuei1412 – 14121PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA6H619.
MaxQBiA6H619.
PaxDbiA6H619.
PeptideAtlasiA6H619.
PRIDEiA6H619.

PTM databases

iPTMnetiA6H619.

Expressioni

Gene expression databases

BgeeiA6H619.
ExpressionAtlasiA6H619. baseline and differential.
GenevisibleiA6H619. MM.

Interactioni

Subunit structurei

Interacts with POLR2A (via the C-terminal domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101648.

Structurei

3D structure databases

ProteinModelPortaliA6H619.
SMRiA6H619. Positions 108-156, 184-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1585 – 161228Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi264 – 406143Arg-richSequence analysisAdd
BLAST
Compositional biasi992 – 1187196Arg-richSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri109 – 15042RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri185 – 23551PHD-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG0825. Eukaryota.
ENOG410YZAI. LUCA.
GeneTreeiENSGT00530000063661.
HOGENOMiHOG000082501.
HOVERGENiHBG108250.
InParanoidiA6H619.
KOiK17586.
OMAiNTFRDQA.
OrthoDBiEOG7F24SX.
PhylomeDBiA6H619.
TreeFamiTF332183.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
SM00184. RING. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1Curated (identifier: A6H619-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDDNLDELV AHSPGPDGPP RVGSSELASD AEESSNGQSG DSEDDTGSEQ
60 70 80 90 100
DDDTDGEETE GLSEEEDPED RSGSEDSEDG VEMATAAIET QGKLEASSVP
110 120 130 140 150
NSDDDAESCP ICLNAFRDQA VGTPETCAHY FCLDCIIEWS RNANSCPVDR
160 170 180 190 200
TVFKCICIRA QFNGKILKKI PVENTKACEA EEEDPTFCEV CGRSDREDRL
210 220 230 240 250
LLCDGCDAGY HMECLDPPLQ EVPVDEWFCP ECTVPGVDPT HDAAPVSDEE
260 270 280 290 300
VSLLLADVVP TTSRLRPRVG RTRAIARTRQ SERVRATVNR NRISSARRVQ
310 320 330 340 350
HVPRYLMSSL LDETIEAVAT GLSTAVYQRP LTPRVPAKRK RKAGRRKKVL
360 370 380 390 400
GRKKTRSRSS VKSKSGSTRA KKRQHRVRKT KGRKLKNEVT ARSRIARTLG
410 420 430 440 450
LRRPVRGTSM PSVYKPVDPS LGLMRADIGA ASLSLFGDPY ELDPFDSNEE
460 470 480 490 500
QSADPPSPLS AKRRVLSRSA LQSHQPVARP VAMGLSRRQL PAVAPEPSVE
510 520 530 540 550
EAPVPDLLGS ILSGQSLLMM SSADVVIHRD GSLSAKRAAP VSLQRNSVTQ
560 570 580 590 600
SREESRLRDN PQPGALPSES ASGGFVGDRQ PNSGLSCGNR TALCCLPARI
610 620 630 640 650
AQTPVRSDPS LTPRSGLSRT LSDENRPSRT HSSSPQLNGS NVRVSSASTK
660 670 680 690 700
IVTHSSFPSK NTASGLPQRT GPRRPDFSKL PRIPKIHRDG NKSTQDQAPA
710 720 730 740 750
SGHIVELPST CISRLTGREG PGQPGRGRVD SEPSSRGPQE TGSHTSGSRP
760 770 780 790 800
PAPSSHGSLA HLGPSRGKGI GSSFESFRIN IPGNTAHCSQ LSSPGFCNTF
810 820 830 840 850
RPVDSKVQRK ETPFPLFSIK KPKQLKSEIY DPFDPTGSDS SPPSSSPESL
860 870 880 890 900
GPGLLPSEIT RTISINSPKA PAFQTVRCVT SYRVESIFGT EMEPEPQPPS
910 920 930 940 950
EPVSGMLELL SKGSAEGTSD LEQEGLGEIE PTEIRGSTAR TQRPPPPDPW
960 970 980 990 1000
DDEDEVSCTP FFGSEERTVT CVTVEEPGVL PSPDAPQITT HRIVEFRASS
1010 1020 1030 1040 1050
RSRSTSSSRS RKKTKKKKKK VAREHQRTRS STRSGSRDRT SRSVSPVAEE
1060 1070 1080 1090 1100
HTRRHRAKTK SRRSSSDRAS SQDRAKRRKD RDDRDREHRR GSWGHGRCRR
1110 1120 1130 1140 1150
KSRSRSGSPG SSSCERHESK RRKRRHSGSR SRGSSLERDR RHKHRERSRE
1160 1170 1180 1190 1200
RMDKQESVTR SRERRRWRSR SPSLEHRPRR PPSREKRAHS PEKKGPVREV
1210 1220 1230 1240 1250
SPAPATQGES RQDGDHSAEP PVSEVSVLPE VVSVLPEVVV ADLNPPEVPP
1260 1270 1280 1290 1300
VLAEPVAHVP EDLDYGESVE AGHVFEDFSN EAIFIQLDDM SSPPSPESTD
1310 1320 1330 1340 1350
SSPERDFPPN PILPPASLPQ DSTLPTIQRE VLPIHSEDIS KPVPQALAPS
1360 1370 1380 1390 1400
DQSLLKQDTV EITTTTPSTP AVVPMTKDSP VLSARGWEAV RPRDAVAQAP
1410 1420 1430 1440 1450
LLRSRTLVKR VTWNLQEAEH STPAALDRDP RTPLQRPQRP QEGDWDAEDR
1460 1470 1480 1490 1500
ALIGFQQAPF SELPPPIHVL QESGLPDADP SQPPGAPRAE GLPAAGTLHS
1510 1520 1530 1540 1550
AGGILAQVYS PNMPPPLAQP SSILPYALVS QPSVQLILQG TLPLAGCGTA
1560 1570 1580 1590 1600
QSLAPVPTMP ATVSELAVPT TNNSEERTAT PKTAAEKTKK EEYMKKLHMQ
1610 1620 1630 1640 1650
ERAVEEVKLA IKPFYQKREV TKEEYKDILR KAVQKICHSK SGEINPVKVA
1660 1670 1680
NLVKAYVDKY RHMRRHKKTE GGEEPPTQGA ET
Note: Gene prediction based on EST data.Curated
Length:1,682
Mass (Da):184,081
Last modified:November 25, 2008 - v2
Checksum:i97F5B67545D7A105
GO
Isoform 21 Publication (identifier: A6H619-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     160-169: AQFNGKILKK → MFTDQYFCLQ

Note: No experimental confirmation available.Curated
Show »
Length:1,523
Mass (Da):167,288
Checksum:iE124025EF75635F5
GO

Sequence cautioni

The sequence BAC98197.1 differs from that shown.The sequence differs from that shown because it seems to be derived from a pre-mRNA.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 159159Missing in isoform 2. 1 PublicationVSP_052978Add
BLAST
Alternative sequencei160 – 16910AQFNGKILKK → MFTDQYFCLQ in isoform 2. 1 PublicationVSP_052979

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108908 Genomic DNA. No translation available.
AC163434 Genomic DNA. No translation available.
BC094566 mRNA. Translation: AAH94566.1.
BC138446 mRNA. Translation: AAI38447.1.
BC145719 mRNA. Translation: AAI45720.1.
AK129387 Transcribed RNA. Translation: BAC98197.1. Sequence problems.
CCDSiCCDS52441.1. [A6H619-1]
RefSeqiNP_001074587.1. NM_001081118.1. [A6H619-1]
UniGeneiMm.248656.

Genome annotation databases

EnsembliENSMUST00000106027; ENSMUSP00000101648; ENSMUSG00000038611. [A6H619-1]
ENSMUST00000122143; ENSMUSP00000113195; ENSMUSG00000038611. [A6H619-2]
GeneIDi101471.
KEGGimmu:101471.
UCSCiuc009kkb.1. mouse. [A6H619-1]
uc009kkc.1. mouse. [A6H619-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108908 Genomic DNA. No translation available.
AC163434 Genomic DNA. No translation available.
BC094566 mRNA. Translation: AAH94566.1.
BC138446 mRNA. Translation: AAI38447.1.
BC145719 mRNA. Translation: AAI45720.1.
AK129387 Transcribed RNA. Translation: BAC98197.1. Sequence problems.
CCDSiCCDS52441.1. [A6H619-1]
RefSeqiNP_001074587.1. NM_001081118.1. [A6H619-1]
UniGeneiMm.248656.

3D structure databases

ProteinModelPortaliA6H619.
SMRiA6H619. Positions 108-156, 184-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101648.

PTM databases

iPTMnetiA6H619.

Proteomic databases

EPDiA6H619.
MaxQBiA6H619.
PaxDbiA6H619.
PeptideAtlasiA6H619.
PRIDEiA6H619.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106027; ENSMUSP00000101648; ENSMUSG00000038611. [A6H619-1]
ENSMUST00000122143; ENSMUSP00000113195; ENSMUSG00000038611. [A6H619-2]
GeneIDi101471.
KEGGimmu:101471.
UCSCiuc009kkb.1. mouse. [A6H619-1]
uc009kkc.1. mouse. [A6H619-2]

Organism-specific databases

CTDi57661.
MGIiMGI:2141847. Phrf1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0825. Eukaryota.
ENOG410YZAI. LUCA.
GeneTreeiENSGT00530000063661.
HOGENOMiHOG000082501.
HOVERGENiHBG108250.
InParanoidiA6H619.
KOiK17586.
OMAiNTFRDQA.
OrthoDBiEOG7F24SX.
PhylomeDBiA6H619.
TreeFamiTF332183.

Miscellaneous databases

ChiTaRSiPhrf1. mouse.
PROiA6H619.
SOURCEiSearch...

Gene expression databases

BgeeiA6H619.
ExpressionAtlasiA6H619. baseline and differential.
GenevisibleiA6H619. MM.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
SM00184. RING. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 468-1682 (ISOFORMS 1/2).
    Strain: C57BL/6JImported.
    Tissue: BrainImported.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 539-1430 (ISOFORMS 1/2).
    Tissue: Embryonic tailImported.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-919, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiPHRF1_MOUSE
AccessioniPrimary (citable) accession number: A6H619
Secondary accession number(s): Q505G1, Q6ZPN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: July 6, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.