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A6H4Q3 (COX3_VANPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Cytochrome oxidase subunit 3
Gene names
Name:COX3
ORF Names:VapofMp03
Encoded onMitochondrion
OrganismVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) [Complete proteome]
Taxonomic identifier436907 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaerobic electron transport chain

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Cytochrome c oxidase subunit 3
PRO_0000356871

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane46 – 6621Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane128 – 14821Helical; Potential
Transmembrane168 – 18821Helical; Potential
Transmembrane205 – 22521Helical; Potential
Transmembrane248 – 26821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A6H4Q3 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 4A70613718F762ED

FASTA27030,483
        10         20         30         40         50         60 
MLNYMERSKH QQFPFHLVNP SPWPIVVSFS LLSLALSLGL TMHGYIGEMY LVNLALLVVL 

        70         80         90        100        110        120 
GSGVLWFRDI IAEATYLGDH TAAVRKGINI GFLLFVLSEV LIFSALFWSY FHSAMSPDVT 

       130        140        150        160        170        180 
LGACWPPVGI TAVQPTELPL LNTIILLASG ATVTYSHHAL IQGNRKNSLS GLLITTWLII 

       190        200        210        220        230        240 
IFVICQYIEY TNATFTISDG VYGSVFFAGT GLHFLHMVML AIMLAVCYWR LRNYHLTNSH 

       250        260        270 
HVGYETTIIY LHVLDVIWLF LYIVFYWWGV 

« Hide

References

[1]"Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 22028 / DSM 70294.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM698041 Genomic DNA. Translation: CAN85576.1.
RefSeqYP_001331015.1. NC_009638.1.

3D structure databases

ProteinModelPortalA6H4Q3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING436907.A6H4Q3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5329655.
KEGGvpo:VapofMp03.

Phylogenomic databases

eggNOGCOG1845.
KOK02262.
OrthoDBEOG7V76HP.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_VANPO
AccessionPrimary (citable) accession number: A6H4Q3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families