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A6H4Q3

- COX3_VANPO

UniProt

A6H4Q3 - COX3_VANPO

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Protein
Cytochrome c oxidase subunit 3
Gene
COX3, VapofMp03
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Cytochrome oxidase subunit 3
Gene namesi
Name:COX3
ORF Names:VapofMp03
Encoded oniMitochondrion
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
ProteomesiUP000000267: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221Helical; Reviewed prediction
Add
BLAST
Transmembranei46 – 6621Helical; Reviewed prediction
Add
BLAST
Transmembranei88 – 10821Helical; Reviewed prediction
Add
BLAST
Transmembranei128 – 14821Helical; Reviewed prediction
Add
BLAST
Transmembranei168 – 18821Helical; Reviewed prediction
Add
BLAST
Transmembranei205 – 22521Helical; Reviewed prediction
Add
BLAST
Transmembranei248 – 26821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Cytochrome c oxidase subunit 3
PRO_0000356871Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi436907.A6H4Q3.

Structurei

3D structure databases

ProteinModelPortaliA6H4Q3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
KOiK02262.
OrthoDBiEOG7V76HP.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6H4Q3-1 [UniParc]FASTAAdd to Basket

« Hide

MLNYMERSKH QQFPFHLVNP SPWPIVVSFS LLSLALSLGL TMHGYIGEMY    50
LVNLALLVVL GSGVLWFRDI IAEATYLGDH TAAVRKGINI GFLLFVLSEV 100
LIFSALFWSY FHSAMSPDVT LGACWPPVGI TAVQPTELPL LNTIILLASG 150
ATVTYSHHAL IQGNRKNSLS GLLITTWLII IFVICQYIEY TNATFTISDG 200
VYGSVFFAGT GLHFLHMVML AIMLAVCYWR LRNYHLTNSH HVGYETTIIY 250
LHVLDVIWLF LYIVFYWWGV 270
Length:270
Mass (Da):30,483
Last modified:July 24, 2007 - v1
Checksum:i4A70613718F762ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM698041 Genomic DNA. Translation: CAN85576.1.
RefSeqiYP_001331015.1. NC_009638.1.

Genome annotation databases

GeneIDi5329655.
KEGGivpo:VapofMp03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM698041 Genomic DNA. Translation: CAN85576.1 .
RefSeqi YP_001331015.1. NC_009638.1.

3D structure databases

ProteinModelPortali A6H4Q3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 436907.A6H4Q3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5329655.
KEGGi vpo:VapofMp03.

Phylogenomic databases

eggNOGi COG1845.
KOi K02262.
OrthoDBi EOG7V76HP.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication."
    Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 22028 / DSM 70294.

Entry informationi

Entry nameiCOX3_VANPO
AccessioniPrimary (citable) accession number: A6H4Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 24, 2007
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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