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Protein

GTPase HflX

Gene

hflX

Organism
Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi213 – 2131MagnesiumUniRule annotation
Metal bindingi233 – 2331MagnesiumUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi206 – 2138GTPUniRule annotation
Nucleotide bindingi231 – 2355GTPUniRule annotation
Nucleotide bindingi252 – 2554GTPUniRule annotation
Nucleotide bindingi318 – 3214GTPUniRule annotation
Nucleotide bindingi364 – 3663GTPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase HflXUniRule annotation
Alternative name(s):
GTP-binding protein HflXUniRule annotation
Gene namesi
Name:hflXUniRule annotation
Ordered Locus Names:FP2414
OrganismiFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Taxonomic identifieri402612 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
Proteomesi
  • UP000006394 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: May associate with membranes.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413GTPase HflXPRO_0000412657Add
BLAST

Interactioni

Subunit structurei

Monomer. Associates with the 50S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi402612.FP2414.

Structurei

3D structure databases

ProteinModelPortaliA6H294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini200 – 386187Hflx-type GUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.UniRule annotation
Contains 1 Hflx-type G (guanine nucleotide-binding) domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1N. Bacteria.
COG2262. LUCA.
HOGENOMiHOG000260368.
KOiK03665.
OMAiEDYAGHE.
OrthoDBiEOG60SCM2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00900. GTPase_HflX.
InterProiIPR030394. G_HFLX_dom.
IPR032305. GTP-bd_M.
IPR006073. GTP_binding_domain.
IPR016496. GTPase_HflX.
IPR025121. GTPase_HflX_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10229. PTHR10229. 1 hit.
PfamiPF16360. GTP-bdg_M. 1 hit.
PF13167. GTP-bdg_N. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF006809. GTP-binding_hflX_prd. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03156. GTP_HflX. 1 hit.
PROSITEiPS51705. G_HFLX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6H294-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEKETINFE KTIIVGIVTQ NQSEEKLKEY LDELEFLTFT AGGEVVKRFS
60 70 80 90 100
QKMERPNPKT FLGTGKIEEI NLYVLENGIS TIVFDDELTP SQQKNISKII
110 120 130 140 150
DCKILDRTHL ILDIFAQRAE TSYARTQVEL AQCIYLLPRL SGMWTHLERQ
160 170 180 190 200
KGGIGMRGPG ETEIETDRRI VRDRIALLKE KIKIIDKQQA TQRGNRGAMV
210 220 230 240 250
RVALVGYTNV GKSTLMNAVG KSDVFVENKL FATLDTTVRK VVIKNLPFLL
260 270 280 290 300
SDTVGFIRKL PTQLVDSFKS TLDEVREADL LLHVVDISHQ DFEDHIDAVN
310 320 330 340 350
KILLDIKSAD KPTIMVFNKI DAYKHLTIDA DDLMTERTSK HYTLQEWKNT
360 370 380 390 400
WMNKVGEQNA LFISATNKEN FEEFRKKVYE TVREIHITRF PYNKFLYPDY
410
EDAIDKEEEQ DQD
Length:413
Mass (Da):47,692
Last modified:July 24, 2007 - v1
Checksum:i1F43C3801251A3AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM398681 Genomic DNA. Translation: CAL44468.1.
RefSeqiWP_011964502.1. NC_009613.3.
YP_001297269.1. NC_009613.3.

Genome annotation databases

EnsemblBacteriaiCAL44468; CAL44468; FP2414.
GeneIDi5299510.
KEGGifps:FP2414.
PATRICi21909870. VBIFlaPsy4505_2470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM398681 Genomic DNA. Translation: CAL44468.1.
RefSeqiWP_011964502.1. NC_009613.3.
YP_001297269.1. NC_009613.3.

3D structure databases

ProteinModelPortaliA6H294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402612.FP2414.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL44468; CAL44468; FP2414.
GeneIDi5299510.
KEGGifps:FP2414.
PATRICi21909870. VBIFlaPsy4505_2470.

Phylogenomic databases

eggNOGiENOG4105C1N. Bacteria.
COG2262. LUCA.
HOGENOMiHOG000260368.
KOiK03665.
OMAiEDYAGHE.
OrthoDBiEOG60SCM2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00900. GTPase_HflX.
InterProiIPR030394. G_HFLX_dom.
IPR032305. GTP-bd_M.
IPR006073. GTP_binding_domain.
IPR016496. GTPase_HflX.
IPR025121. GTPase_HflX_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10229. PTHR10229. 1 hit.
PfamiPF16360. GTP-bdg_M. 1 hit.
PF13167. GTP-bdg_N. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF006809. GTP-binding_hflX_prd. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03156. GTP_HflX. 1 hit.
PROSITEiPS51705. G_HFLX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JIP02/86 / ATCC 49511.

Entry informationi

Entry nameiHFLX_FLAPJ
AccessioniPrimary (citable) accession number: A6H294
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: July 24, 2007
Last modified: November 11, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.