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A6H260 (A6H260_FLAPJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 2 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 2 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 2 HAMAP MF_01815
Gene names
Name:fabH3 EMBL CAL44434.1
Synonyms:fabH2 HAMAP MF_01815
Ordered Locus Names:FP2379
OrganismFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Taxonomic identifier402612 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region257 – 2615ACP-binding By similarity HAMAP MF_01815

Sites

Active site1161 By similarity HAMAP MF_01815
Active site2561 By similarity HAMAP MF_01815
Active site2861 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
A6H260 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 9004650193A01334

FASTA33336,304
        10         20         30         40         50         60 
MNTITAAITA VGAYVPEFVL SNKVLETMID TNDEWITSRT GIKERRILKE KGTGTSYLAI 

        70         80         90        100        110        120 
KAAQNLIEKS GINPAEIDMV IMATATPDMP VASTGVFVAT QIGAVNAFAY DLQAACSSFL 

       130        140        150        160        170        180 
YGMSTAAAYI HSGRYKKVLL IGADKMSSII DYTDRATCII FGDGAGAVLF EPNTEGLGLQ 

       190        200        210        220        230        240 
DEYLRSDGIG RDYLKIDAGG SLLPSSKETI ENKQHTVVQD GKTVFKYAVS GMADVSEKIM 

       250        260        270        280        290        300 
QRNNLTHENV NWLIAHQANK RIIDATAQRM GVDESKVLIN IERYGNTTSA TLPLLLSDFE 

       310        320        330 
NKFKKGDNLI FAAFGGGFTW GSIYLKWAYD KKD

« Hide

References

[1]"Complete genome sequence of the fish pathogen Flavobacterium psychrophilum."
Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B., Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F., Claverol S., Dumetz F., Le Henaff M., Benmansour A.
Nat. Biotechnol. 25:763-769(2007) [PubMed: 17592475] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JIP02/86 / ATCC 49511.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM398681 Genomic DNA. Translation: CAL44434.1.
RefSeqYP_001297235.1. NC_009613.1.

3D structure databases

ProteinModelPortalA6H260.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6H260.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5299135.
GenomeReviewsGene locus FP2379 in contig AM398681_GR.
KEGGfps:FP2379.
NMPDRfig|402612.4.peg.2337.
PATRIC21909800. VBIFlaPsy4505_2436.

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMAKEIGAIN.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA6H260_FLAPJ
AccessionPrimary (citable) accession number: A6H260
Entry history
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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