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A6H244

- SYL_FLAPJ

UniProt

A6H244 - SYL_FLAPJ

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei740 – 7401ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:FP2363
OrganismiFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Taxonomic identifieri402612 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
ProteomesiUP000006394: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Leucine--tRNA ligasePRO_1000009339Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402612.FP2363.

Structurei

3D structure databases

ProteinModelPortaliA6H244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi737 – 7415"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6H244 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYNPNEIDA KWQKNWANNQ TFAASNTSIK PKYYILDMFP YPSGAGLHVG
60 70 80 90 100
HPLGYIASDI VARFKRHKGF NVLHPQGYDS FGLPAEQYAI QTGQHPDKTT
110 120 130 140 150
KENIARYREQ LDKIGFSFDW SREIRTSNAN YYKHTQWIFI QLFNSWYNKS
160 170 180 190 200
NDKAEDITTL ISLFQKEGNT NINAVCDDNI APFSAQDWTG FSSSKQQKIL
210 220 230 240 250
LQYRLTYLAE TEVNWCPGLG TVLANDEIIN GVSERGGHPV IRKKMTQWSM
260 270 280 290 300
RISAYAERLL QGLNDIDWSE SIKESQRNWI GKSVGAMVSF KVKNQKSQVT
310 320 330 340 350
SEATLSDLRP STLDYIEVFT TRPDTIFGVT FMTLAPEHPL VQEITTPEQK
360 370 380 390 400
AAIEAYIEKT AKRSERERMA DVKTISGVFT GAYAEHPFTK EQIPVWIGDY
410 420 430 440 450
VLAGYGTGAV MAVPCGDERD YAFANFFKGQ NGMPEIKNIF DNVDIATEAY
460 470 480 490 500
GSKDNVIIAN SDFLNGLNYK QATKKAIAEL ETLNQGKGKT NYRLRDAVFS
510 520 530 540 550
RQRYWGEPFP VYYVNGLPQM IDAKHLPIAL PEVEKYLPTE DGLPPLGNSA
560 570 580 590 600
KWAWNTITNE VDFNENINNT TIYPLELNTM PGWAGSSWYW MRYMDPHNDN
610 620 630 640 650
EFASPEAIKY WESVDLYIGG SEHATGHLLY ARFWNKFLKD KGYAPTEEPF
660 670 680 690 700
KKLINQGMIL GNSAFVYRSE DSKKLYSKGL ISDKTTQAIH VDLAIINETT
710 720 730 740 750
NELDIEAFKK HPLYSDYANA EFILENGKYI VGREVEKMSK SKYNVVNPDD
760 770 780 790 800
ICNEYGADTL RLYEMFLGPL EQSKPWNTAG ITGVFGFLKK LWRLYFDDNG
810 820 830 840 850
LIVTNNEPSK ESLKSLHKTI KKVTEDIENF SFNTSVSQFM ICVNELGTQN
860 870 880 890 900
CHERAILEPL AIILSPYAPH IAEELWSQLG NSESISTVAF PICHEKYLVE
910 920 930 940 950
SDKEYPVSFN GKMKFTINLP LDLTPAQIEE IIMKDERTIK QLDGNTPKKV
960
IIIPGKVINL VG
Length:962
Mass (Da):109,354
Last modified:July 24, 2007 - v1
Checksum:i517F77D040A253F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM398681 Genomic DNA. Translation: CAL44418.1.
RefSeqiWP_011964452.1. NC_009613.3.
YP_001297219.1. NC_009613.3.

Genome annotation databases

EnsemblBacteriaiCAL44418; CAL44418; FP2363.
GeneIDi5299631.
KEGGifps:FP2363.
PATRICi21909768. VBIFlaPsy4505_2420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM398681 Genomic DNA. Translation: CAL44418.1 .
RefSeqi WP_011964452.1. NC_009613.3.
YP_001297219.1. NC_009613.3.

3D structure databases

ProteinModelPortali A6H244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402612.FP2363.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL44418 ; CAL44418 ; FP2363 .
GeneIDi 5299631.
KEGGi fps:FP2363.
PATRICi 21909768. VBIFlaPsy4505_2420.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JIP02/86 / ATCC 49511.

Entry informationi

Entry nameiSYL_FLAPJ
AccessioniPrimary (citable) accession number: A6H244
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3