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A6H244

- SYL_FLAPJ

UniProt

A6H244 - SYL_FLAPJ

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei740 – 7401ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:FP2363
    OrganismiFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
    Taxonomic identifieri402612 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
    ProteomesiUP000006394: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 962962Leucine--tRNA ligasePRO_1000009339Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi402612.FP2363.

    Structurei

    3D structure databases

    ProteinModelPortaliA6H244.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi737 – 7415"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6H244-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYNPNEIDA KWQKNWANNQ TFAASNTSIK PKYYILDMFP YPSGAGLHVG    50
    HPLGYIASDI VARFKRHKGF NVLHPQGYDS FGLPAEQYAI QTGQHPDKTT 100
    KENIARYREQ LDKIGFSFDW SREIRTSNAN YYKHTQWIFI QLFNSWYNKS 150
    NDKAEDITTL ISLFQKEGNT NINAVCDDNI APFSAQDWTG FSSSKQQKIL 200
    LQYRLTYLAE TEVNWCPGLG TVLANDEIIN GVSERGGHPV IRKKMTQWSM 250
    RISAYAERLL QGLNDIDWSE SIKESQRNWI GKSVGAMVSF KVKNQKSQVT 300
    SEATLSDLRP STLDYIEVFT TRPDTIFGVT FMTLAPEHPL VQEITTPEQK 350
    AAIEAYIEKT AKRSERERMA DVKTISGVFT GAYAEHPFTK EQIPVWIGDY 400
    VLAGYGTGAV MAVPCGDERD YAFANFFKGQ NGMPEIKNIF DNVDIATEAY 450
    GSKDNVIIAN SDFLNGLNYK QATKKAIAEL ETLNQGKGKT NYRLRDAVFS 500
    RQRYWGEPFP VYYVNGLPQM IDAKHLPIAL PEVEKYLPTE DGLPPLGNSA 550
    KWAWNTITNE VDFNENINNT TIYPLELNTM PGWAGSSWYW MRYMDPHNDN 600
    EFASPEAIKY WESVDLYIGG SEHATGHLLY ARFWNKFLKD KGYAPTEEPF 650
    KKLINQGMIL GNSAFVYRSE DSKKLYSKGL ISDKTTQAIH VDLAIINETT 700
    NELDIEAFKK HPLYSDYANA EFILENGKYI VGREVEKMSK SKYNVVNPDD 750
    ICNEYGADTL RLYEMFLGPL EQSKPWNTAG ITGVFGFLKK LWRLYFDDNG 800
    LIVTNNEPSK ESLKSLHKTI KKVTEDIENF SFNTSVSQFM ICVNELGTQN 850
    CHERAILEPL AIILSPYAPH IAEELWSQLG NSESISTVAF PICHEKYLVE 900
    SDKEYPVSFN GKMKFTINLP LDLTPAQIEE IIMKDERTIK QLDGNTPKKV 950
    IIIPGKVINL VG 962
    Length:962
    Mass (Da):109,354
    Last modified:July 24, 2007 - v1
    Checksum:i517F77D040A253F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM398681 Genomic DNA. Translation: CAL44418.1.
    RefSeqiYP_001297219.1. NC_009613.3.

    Genome annotation databases

    EnsemblBacteriaiCAL44418; CAL44418; FP2363.
    GeneIDi5299631.
    KEGGifps:FP2363.
    PATRICi21909768. VBIFlaPsy4505_2420.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM398681 Genomic DNA. Translation: CAL44418.1 .
    RefSeqi YP_001297219.1. NC_009613.3.

    3D structure databases

    ProteinModelPortali A6H244.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 402612.FP2363.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL44418 ; CAL44418 ; FP2363 .
    GeneIDi 5299631.
    KEGGi fps:FP2363.
    PATRICi 21909768. VBIFlaPsy4505_2420.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JIP02/86 / ATCC 49511.

    Entry informationi

    Entry nameiSYL_FLAPJ
    AccessioniPrimary (citable) accession number: A6H244
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3