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A6H239 (UPPP_FLAPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:FP2358
OrganismFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511) [Reference proteome] [HAMAP]
Taxonomic identifier402612 [NCBI]
Taxonomic lineageBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000303027

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane69 – 8921Helical; Potential
Transmembrane95 – 11521Helical; Potential
Transmembrane129 – 14921Helical; Potential
Transmembrane169 – 18618Helical; Potential
Transmembrane206 – 22621Helical; Potential
Transmembrane241 – 26121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A6H239 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 2502FC9E60E0FD64

FASTA26128,818
        10         20         30         40         50         60 
MNYIQAIILA IIEGITEFLP VSSTGHMIIA SSFFGIAHED FTKLFTIVIQ LGAILSVVVL 

        70         80         90        100        110        120 
YFKRFFQTLD FYFKLLVAFI PAVVLGLLFS KKIDALLESP VTVAVSLLVG GIILLKVDDW 

       130        140        150        160        170        180 
FNNSSETEIT YLKAFKIGLF QCIAMIPGVS RSGASIVGGM SQKLARTSAA EFSFFLAVPT 

       190        200        210        220        230        240 
MLGATLKKCY DYYKDGFILT HDQINILIIG NIVAFLVALL AIKTFIGFLS KNGFKVFGYY 

       250        260 
RIVAGIVLLL IHFFIHPLTL I 

« Hide

References

[1]"Complete genome sequence of the fish pathogen Flavobacterium psychrophilum."
Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B., Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F., Claverol S., Dumetz F., Le Henaff M., Benmansour A.
Nat. Biotechnol. 25:763-769(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JIP02/86 / ATCC 49511.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM398681 Genomic DNA. Translation: CAL44413.1.
RefSeqYP_001297214.1. NC_009613.3.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING402612.FP2358.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL44413; CAL44413; FP2358.
GeneID5299823.
KEGGfps:FP2358.
PATRIC21909756. VBIFlaPsy4505_2414.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_FLAPJ
AccessionPrimary (citable) accession number: A6H239
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 24, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families