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A6H239

- UPPP_FLAPJ

UniProt

A6H239 - UPPP_FLAPJ

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:FP2358
    OrganismiFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
    Taxonomic identifieri402612 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
    ProteomesiUP000006394: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Undecaprenyl-diphosphatasePRO_0000303027Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi402612.FP2358.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei41 – 6121HelicalUniRule annotationAdd
    BLAST
    Transmembranei69 – 8921HelicalUniRule annotationAdd
    BLAST
    Transmembranei95 – 11521HelicalUniRule annotationAdd
    BLAST
    Transmembranei129 – 14921HelicalUniRule annotationAdd
    BLAST
    Transmembranei169 – 18618HelicalUniRule annotationAdd
    BLAST
    Transmembranei206 – 22621HelicalUniRule annotationAdd
    BLAST
    Transmembranei241 – 26121HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6H239-1 [UniParc]FASTAAdd to Basket

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    MNYIQAIILA IIEGITEFLP VSSTGHMIIA SSFFGIAHED FTKLFTIVIQ    50
    LGAILSVVVL YFKRFFQTLD FYFKLLVAFI PAVVLGLLFS KKIDALLESP 100
    VTVAVSLLVG GIILLKVDDW FNNSSETEIT YLKAFKIGLF QCIAMIPGVS 150
    RSGASIVGGM SQKLARTSAA EFSFFLAVPT MLGATLKKCY DYYKDGFILT 200
    HDQINILIIG NIVAFLVALL AIKTFIGFLS KNGFKVFGYY RIVAGIVLLL 250
    IHFFIHPLTL I 261
    Length:261
    Mass (Da):28,818
    Last modified:July 24, 2007 - v1
    Checksum:i2502FC9E60E0FD64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM398681 Genomic DNA. Translation: CAL44413.1.
    RefSeqiYP_001297214.1. NC_009613.3.

    Genome annotation databases

    EnsemblBacteriaiCAL44413; CAL44413; FP2358.
    GeneIDi5299823.
    KEGGifps:FP2358.
    PATRICi21909756. VBIFlaPsy4505_2414.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM398681 Genomic DNA. Translation: CAL44413.1 .
    RefSeqi YP_001297214.1. NC_009613.3.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 402612.FP2358.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL44413 ; CAL44413 ; FP2358 .
    GeneIDi 5299823.
    KEGGi fps:FP2358.
    PATRICi 21909756. VBIFlaPsy4505_2414.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JIP02/86 / ATCC 49511.

    Entry informationi

    Entry nameiUPPP_FLAPJ
    AccessioniPrimary (citable) accession number: A6H239
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3