A6H211 (A6H211_FLAPJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid-A-disaccharide synthase EMBL CAL44385.1
EC=2.4.1.182 EMBL CAL44385.1

Gene names

Name:	lpxB EMBL CAL44385.1
Ordered Locus Names:	FP2330

Organism

Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)

Taxonomic identifier

402612 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL CAL44385.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A6H211 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 319A65E012D8197E	FASTA	376	42,943
	10 20 30 40 50 60 MKYYIIAGEA SGDLHGSNLM KGIYKEDSQA DIRFWGGDLM QQTGGTLVKH YRDLSFMGFL 70 80 90 100 110 120 EVVLNLKTIL NNIKTCKADI ISFKPHAIIF IDYPGFNMRI AKWSKKLGIR NHYYISPQIW 130 140 150 160 170 180 AWKENRIKAI KNDVDKMYVI LPFEKDFYEK KHHFSVEFVG HPLIDAINNR QKTNATQFKK 190 200 210 220 230 240 DNNLDGRPII ALLPGSRKQE IEKMLSKMLS VVKDFPNHQF VIAGAPSQEY SFYKQFLTNN 250 260 270 280 290 300 QVHFIANKTY DLLSISQAAL VTSGTATLET ALFKVPEVVL YKGSWASYQI AKRIITLKYI 310 320 330 340 350 360 SLVNLIMNKE VVTELIQDDC NSEKIKAELE KIIQPSYRST LLENYDLLEK QLGGAGASDK 370 TAGLIVRDMF KQSSKS

References

[1]

"Complete genome sequence of the fish pathogen Flavobacterium psychrophilum." Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B., Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F., Claverol S., Dumetz F., Le Henaff M., Benmansour A. Nat. Biotechnol. 25:763-769(2007) [PubMed: 17592475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JIP02/86 / ATCC 49511.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM398681 Genomic DNA. Translation: CAL44385.1.
RefSeq	YP_001297186.1. NC_009613.1.
3D structure databases
ProteinModelPortal	A6H211.
ModBase	Search...
Protein-protein interaction databases
STRING	A6H211.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5299276.
GenomeReviews	Gene locus FP2330 in contig AM398681_GR.
KEGG	fps:FP2330.
NMPDR	fig|402612.4.peg.2286.
PATRIC	21909696. VBIFlaPsy4505_2384.
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	AEFAFIC.
ProtClustDB	CLSK823744.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A6H211_FLAPJ

Accession

Primary (citable) accession number: A6H211

Entry history

Integrated into UniProtKB/TrEMBL:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)